Ana C. Andreazza
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View article: Cognitive rehabilitation among long COVID patients using vibratory and auditory treatment (VAT) is linked to BDNF
Cognitive rehabilitation among long COVID patients using vibratory and auditory treatment (VAT) is linked to BDNF Open
Cognitive dysfunction occurs in around 40% of long COVID (LC) patients, and in many cases appears second only to fatigue in prevalence. Vibratory and auditory treatment (VAT) within the gamma range has demonstrated improvements in symptoms…
View article: Unhealthy diet quality as a clinical phenotype in bipolar disorder: A potential treatment target for improved mood and metabolic outcomes
Unhealthy diet quality as a clinical phenotype in bipolar disorder: A potential treatment target for improved mood and metabolic outcomes Open
These findings highlight the importance of investigating diet quality as a potential therapeutic target in the management of BD to improve mood outcomes and mitigate risk of metabolic disorders.
View article: Greater Mitochondrial DNA Pathogenicity is Associated with Greater Regional Cerebral Blood Flow in Youth Bipolar Disorder
Greater Mitochondrial DNA Pathogenicity is Associated with Greater Regional Cerebral Blood Flow in Youth Bipolar Disorder Open
Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Mitochondrial DNA (mtDNA) variants are associated with anomalous cerebral energy metabolism and with increased risk for BD. Little is known about the r…
View article: iPSC-derived cerebral organoids reveal mitochondrial, inflammatory and neuronal vulnerabilities in bipolar disorder
iPSC-derived cerebral organoids reveal mitochondrial, inflammatory and neuronal vulnerabilities in bipolar disorder Open
Bipolar disorder (BD) is increasingly recognized as a disease with both mitochondrial dysfunction and heightened inflammatory reactivity, yet contribution to neuronal activity remains unclear. To address these gaps, this study utilizes iPS…
View article: A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial
A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial Open
INTRODUCTION: Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease and related dementias (ADRD), offers a critical window for early intervention. Mitochondrial dysfunction is increasingly recognized as a driver of neur…
View article: Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <scp>ISBD</scp> Task Force
Defining Treatment‐Resistant Bipolar Depression: Recommendations From the <span>ISBD</span> Task Force Open
Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to…
View article: Brain glucose and ketone metabolism in first-episode psychosis: Neuroimaging and brain metabolism before and after antipsychotic treatment: The protocol for the CAST-ATP study
Brain glucose and ketone metabolism in first-episode psychosis: Neuroimaging and brain metabolism before and after antipsychotic treatment: The protocol for the CAST-ATP study Open
First episode of psychosis (FEP) has an early onset and is associated with significant functional impairment, loss of productivity and premature cardiovascular disease. Antipsychotics (AP) remain the cornerstone treatment of FEP yet they f…
View article: Les premiers succès de la piste immuno-métabolique en psychiatrie de précision
Les premiers succès de la piste immuno-métabolique en psychiatrie de précision Open
Les troubles psychiatriques sont associés à une forte prévalence de facteurs de risque cardiovasculaires et métaboliques, tels que le diabète, l’obésité et le syndrome métabolique. Ils présentent également des symptômes spécifiques, notamm…
View article: A population-based cohort study of mitochondrial disease and mental health conditions in Ontario, Canada
A population-based cohort study of mitochondrial disease and mental health conditions in Ontario, Canada Open
View article: iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory and Neuronal Vulnerabilities in Bipolar Disorder
iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory and Neuronal Vulnerabilities in Bipolar Disorder Open
Bipolar disorder (BD) is increasingly recognized as a disorder with both mitochondrial dysfunction and heightened inflammatory reactivity, yet their contribution to neuronal activity remains unclear. To address these gaps, this study utili…
View article: Vascular endothelial growth factor and regional cerebral blood flow in early Alzheimer’s disease
Vascular endothelial growth factor and regional cerebral blood flow in early Alzheimer’s disease Open
This manuscript supports the findings from previous in vitro and in vivo Alzheimer’s disease (AD) studies where angiogenesis was associated with cerebral blood flow (CBF) changes. Using both neuroimaging and neurophysiology measures, this …
View article: Transcranial Photobiomodulation (tPBM) for Mild Cognitive Impairment (MCI): Key Findings from a Pilot Randomized Clinical Trial
Transcranial Photobiomodulation (tPBM) for Mild Cognitive Impairment (MCI): Key Findings from a Pilot Randomized Clinical Trial Open
View article: Referee report. For: Model systems informing mechanisms and drug discovery: a review of POLG-related disease models [version 2; peer review: 1 approved, 2 not approved]
Referee report. For: Model systems informing mechanisms and drug discovery: a review of POLG-related disease models [version 2; peer review: 1 approved, 2 not approved] Open
View article: Metabolic Abnormalities in Psychiatric Disorders A Transdiagnostic, Whole-Body Approach
Metabolic Abnormalities in Psychiatric Disorders A Transdiagnostic, Whole-Body Approach Open
View article: Metabolic Psychiatry: A Conceptual Framework Targeting Metabolic Dysfunction in Psychiatric Disease
Metabolic Psychiatry: A Conceptual Framework Targeting Metabolic Dysfunction in Psychiatric Disease Open
An intricate link exists between metabolic dysfunction and psychiatric disease. Documented deficits in systemic and brain metabolism are seen in several major mental illnesses: schizophrenia (SZ), bipolar disorder (BD), and major depressiv…
View article: A pilot study evaluating the feasibility, safety, and efficacy of transcranial photobiomodulation (tPBM) for the treatment of mild cognitive impairment (MCI): preliminary findings
A pilot study evaluating the feasibility, safety, and efficacy of transcranial photobiomodulation (tPBM) for the treatment of mild cognitive impairment (MCI): preliminary findings Open
Background Mild Cognitive Impairment (MCI) is often a precursor to Alzheimer’s dementia (AD). Recent research underscores the relationship between mitochondrial dysfunction and amyloid‐beta accumulation, raising the prospect of targeting m…
View article: Brain glutathione in vascular mild cognitive impairment and cognitive correlates
Brain glutathione in vascular mild cognitive impairment and cognitive correlates Open
Background Oxidative stress (OS) has been implicated in age‐related neurodegeneration and may be important in prodromal states such as vascular mild cognitive impairment (vMCI). Higher peripheral OS is reported in vMCI patients; however, t…
View article: Examining the relationship between angiopoietin‐2 and cognition in early Alzheimer’s disease
Examining the relationship between angiopoietin‐2 and cognition in early Alzheimer’s disease Open
Background Angiopoietin‐2, which regulates endothelial permeability and angiogenesis functions, is emerging as a potential biomarker for early Alzheimer’s disease (AD). Elevated levels of cerebrospinal fluid angiopoietin‐2 concentrations h…
View article: Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT)
Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT) Open
Background Oxidative stress (OS) has been a target of interest for vascular dementia, given its implications in pathogenesis. OS may be important in prodromal stage, such as vascular mild cognitive impairment (vMCI), and examining OS marke…
View article: Mitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review
Mitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review Open
Mitochondria are organelles involved in different cellular functions, especially energy production. A relationship between mitochondrial dysfunction and mood disorders, especially bipolar disorder (BD), has been reported in the scientific …
View article: Ana Cristina Andreazza: Driven by curiosity – transforming mental health through mitochondrial innovation
Ana Cristina Andreazza: Driven by curiosity – transforming mental health through mitochondrial innovation Open
Dr. Ana Cristina Andreazza is a Professor of Pharmacology Toxicology and Psychiatry at the University of Toronto, holding the Thomas C. Zachos Chair in Mitochondrial Research and a Tier II Canada Research Chair in Molecular Pharmacology of…
View article: Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder
Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder Open
View article: Euterpe oleracea Mart. Bioactive Molecules: Promising Agents to Modulate the NLRP3 Inflammasome
Euterpe oleracea Mart. Bioactive Molecules: Promising Agents to Modulate the NLRP3 Inflammasome Open
Inflammation is a vital mechanism that defends the organism against infections and restores homeostasis. However, when inflammation becomes uncontrolled, it leads to chronic inflammation. The NLRP3 inflammasome is crucial in chronic inflam…
View article: Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39
Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39 Open
View article: Diet quality and associations with lactate and metabolic syndrome in bipolar disorder
Diet quality and associations with lactate and metabolic syndrome in bipolar disorder Open
Overall, various dietary trends were associated with metabolic syndrome, BMI, lactate, mood and age of onset. Improving our understanding of nutrition in BD can provide mechanistic insight, clinically relevant nutritional guidelines for pr…
View article: The interplay between mitochondria, the gut microbiome and metabolites and their therapeutic potential in primary mitochondrial disease
The interplay between mitochondria, the gut microbiome and metabolites and their therapeutic potential in primary mitochondrial disease Open
The various roles of the mitochondria and the microbiome in health and disease have been thoroughly investigated, though they are often examined independently and in the context of chronic disease. However, the mitochondria and microbiome …
View article: Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder
Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder Open
The object of this study is test whether mitochondrial blood-based biomarkers are associated with markers of metabolic syndrome in bipolar disorder, hypothesizing higher lactate but unchanged cell-free circulating mitochondrial DNA levels …
View article: Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms Open
View article: Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder
Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder Open
Background Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been associated with great…
View article: A population-based cohort study of mitochondrial disease and mental health conditions in Ontario, Canada
A population-based cohort study of mitochondrial disease and mental health conditions in Ontario, Canada Open
Background Mitochondrial disease has been linked to mental health disorder in clinical cohorts and post-mortem studies. However, a lack of population-level studies examining the relationship between mitochondrial disease and mental health …