Ana Maria Caetano Faria
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View article: Oral Treatment With Heat Shock Protein 65‐Producing <i>Lactococcus lactis</i> Induces Regulatory T Cells, Modulating Inflammatory Response in <i>Leishmania braziliensis</i> Infection
Oral Treatment With Heat Shock Protein 65‐Producing <i>Lactococcus lactis</i> Induces Regulatory T Cells, Modulating Inflammatory Response in <i>Leishmania braziliensis</i> Infection Open
Cutaneous leishmaniasis (CL), a neglected tropical disease prevalent in Brazil, is caused by Leishmania braziliensis ( L. braziliensis ) and is marked by ulcerative skin lesions and an exacerbated Th1‐driven inflammatory response. This stu…
View article: Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects
Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects Open
The laterodorsal tegmentum (LDT) sends critical inputs to distinct reward circuit regions, including the nucleus accumbens (NAc), but their functional role in addiction-related behaviors remains underexplored. Here, we demonstrate that LDT…
View article: Immunosenescence Profile Is Associated With Increased Susceptibility to Severe <scp>COVID</scp> ‐19
Immunosenescence Profile Is Associated With Increased Susceptibility to Severe <span>COVID</span> ‐19 Open
In this study, we tested the hypothesis that the immunosenescence profile could account for the disproportional susceptibility of the elderly to severe forms of COVID‐19. The immunological profiles of volunteers residing in endemic and non…
View article: Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures
Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures Open
Research on aged individuals from developed countries show that lifestyle factors such as diet, physical activity, stress, smoking, and sleep quality impact aging. However, other relevant factors may influence aging in less-studied populat…
View article: Rhythms and shifts of chemokines and cytokines interplay in a decade lifespan: The longitudinal community-based Bambuí health and aging study
Rhythms and shifts of chemokines and cytokines interplay in a decade lifespan: The longitudinal community-based Bambuí health and aging study Open
Aging is associated with several physiological changes, including a remarkable remodeling of the immune system. Herein, the rhythms and shifts in serum immune mediators were characterized in a decade lifespan as a longitudinal community-ba…
View article: Immunosenescence profile is associated with increased susceptibility to severe COVID-19
Immunosenescence profile is associated with increased susceptibility to severe COVID-19 Open
In this study we tested the hypothesis that the immunosenescence profile could account for the disproportional susceptibility of the elderly to severe forms of COVID-19. The immunological profiles of volunteers residing in endemic and non-…
View article: Behavioral changes and transcriptional regulation of mesolimbic dopaminergic genes in a mouse model of binge eating disorder by diet intermittent access
Behavioral changes and transcriptional regulation of mesolimbic dopaminergic genes in a mouse model of binge eating disorder by diet intermittent access Open
Binge Eating Disorder (BED) is among the most prevalent eating disorders worldwide. It is characterized by recurrent episodes of excessive consumption of palatable foods in short periods, accompanied by a sense of loss of control and distr…
View article: Obesity alters the macrophages’ response to <i>Leishmania major</i> in C57BL/6 mice
Obesity alters the macrophages’ response to <i>Leishmania major</i> in C57BL/6 mice Open
Obesity is a global pandemic associated with several comorbidities, such as cardiovascular diseases and type 2 diabetes. It is also a predisposing factor for infectious diseases, increasing mortality rates. Moreover, diet-induced obesity c…
View article: Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis
Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis Open
Dietary proteins are taken up by intestinal dendritic cells (DCs), cleaved into peptides, loaded to major histocompatibility complexes, and presented to T cells to generate an immune response. Amino acid (AA)-diets do not have the same eff…
View article: Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins
Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins Open
Capsaicin, a pungent compound in chili peppers, is described as having potent anti-inflammatory, antioxidant, and antimicrobial properties. It is also described as a potential modulator of the immune system and intestinal microbiota. Oral …
View article: Dynamic changes in B cell subpopulations in response to triple-negative breast cancer development
Dynamic changes in B cell subpopulations in response to triple-negative breast cancer development Open
Despite presenting a worse prognosis and being associated with highly aggressive tumors, triple-negative breast cancer (TNBC) is characterized by the higher frequency of tumor-infiltrating lymphocytes, which have been implicated in better …
View article: Recombinant probiotic Lactococcus lactis delivering P62 mitigates moderate colitis in mice
Recombinant probiotic Lactococcus lactis delivering P62 mitigates moderate colitis in mice Open
Introduction and objective p62 is a human multifunctional adaptor protein involved in key cellular processes such as tissue homeostasis, inflammation, and cancer. It acts as a negative regulator of inflammasome complexes. It may thus be co…
View article: Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model
Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model Open
Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affect…
View article: Impact of murine breast tumor development in the kinetics of B cell subpopulations
Impact of murine breast tumor development in the kinetics of B cell subpopulations Open
Despite presenting a worse prognosis and being associated with highly aggressive tumors, triple-negative breast cancer (TNBC) is characterized by the higher frequency of tumor-infiltrating lymphocytes, which have been implicated in better …
View article: Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling
Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling Open
Chronic consumption of hyperpalatable and hypercaloric foods has been pointed out as a factor associated with cognitive decline and memory impairment in obesity. In this context, the integration between peripheral and central inflammation …
View article: A new experimental model to study shrimp allergy
A new experimental model to study shrimp allergy Open
Shrimp is among the most sensitizing food allergens and has been associated with many anaphylaxis reactions. However, there is still a shortage of studies that enable a systematic understanding of this disease and the investigation of new …
View article: Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy Open
Obesity and type 2 diabetes (T2D) have been found to be associated with abnormalities in several organs, including the intestine. These conditions can lead to changes in gut homeostasis, compromising tolerance to luminal antigens and incre…
View article: Chronic Hyperpalatable Diet Impairs Hippocampal-dependent Memories by Disrupting Glutamatergic and Fractalkine Axis Signaling
Chronic Hyperpalatable Diet Impairs Hippocampal-dependent Memories by Disrupting Glutamatergic and Fractalkine Axis Signaling Open
Chronic consumption of hyperpalatable and hypercaloric foods has been pointed out as a factor associated with cognitive decline and memory impairment in obesity. In this context, the integration between peripheral and central inflammation …
View article: Animal model for high consumption and preference of ethanol and its interplay with high sugar and butter diet, behavior, and neuroimmune system
Animal model for high consumption and preference of ethanol and its interplay with high sugar and butter diet, behavior, and neuroimmune system Open
Introduction Mechanisms that dictate the preference for ethanol and its addiction are not only restricted to the central nervous system (CNS). An increasing body of evidence has suggested that abusive ethanol consumption directly affects t…
View article: COVID-19 INDUCES SENESCENCE AND EXHAUSTION OF T CELLS IN PATIENTS WITH MILD/MODERATE AND SEVERE DISEASE DURING A SEVEN-DAY INTERVAL
COVID-19 INDUCES SENESCENCE AND EXHAUSTION OF T CELLS IN PATIENTS WITH MILD/MODERATE AND SEVERE DISEASE DURING A SEVEN-DAY INTERVAL Open
Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-Cov-2. Major drivers that can explain this markedly unfavour…
View article: <b>p62 Protein-Based Gene Therapy Modulates the Immune Responses in Moderate DSS-induced Colitis in Mice</b>
<b>p62 Protein-Based Gene Therapy Modulates the Immune Responses in Moderate DSS-induced Colitis in Mice</b> Open
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC), constitute chronic inflammatory ailments of the gastrointestinal tract (GIT). These inflammatory diseases result from many factors, including the host's immune response,…
View article: EFFECTS OF GLUTEN-FREE DIET ON INDIVIDUALS WITH AXIAL SPONDYLOARTHRITIS - RESULTS OF A PILOT RANDOMIZED DOUBLE-BLINDED TRIAL WITH DIETETIC INTERVENTION
EFFECTS OF GLUTEN-FREE DIET ON INDIVIDUALS WITH AXIAL SPONDYLOARTHRITIS - RESULTS OF A PILOT RANDOMIZED DOUBLE-BLINDED TRIAL WITH DIETETIC INTERVENTION Open
Axial Spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease whose pathophysiology is also associated with intestinal dysbiosis and leaky gut (increased permeability of the intestinal barrier to bacteria and their products).…
View article: Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition Open
Breast milk is considered a complete food for babies. Up to 7 days postpartum, it is known as colostrum, rich in immunological compounds, responsible for providing nutrition and ensuring immune protection. However, some maternal factors, s…