Ana Calheiros de Carvalho
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View article: Genomic and metabolomic insights into Trichoderma harzianum T9, a resilient biocontrol fungus from arid environments
Genomic and metabolomic insights into Trichoderma harzianum T9, a resilient biocontrol fungus from arid environments Open
The search for sustainable agricultural solutions to reduce pesticide use is increasingly urgent, particularly under the growing pressures of climate change. Microorganisms from extreme environments offer valuable potential for biocontrol …
View article: A biosynthetic survey of biocontrol fungi
A biosynthetic survey of biocontrol fungi Open
Pests are responsible for the loss of up to 40% of global crops. Widespread resistance to pesticides has emerged due to the overuse of a limited set of compounds and targets. This overreliance has driven the rapid adaptation of pest popula…
View article: Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A
Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A Open
View article: Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides
Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides Open
Fungal natural products, including polyketides, are a rich source of bioactive molecules. Their biosynthetic enzymes are encoded within biosynthetic gene clusters, which are often activated by specific environmental conditions. As a result…
View article: Neurospora intermedia from a traditional fermented food enables waste-to-food conversion
Neurospora intermedia from a traditional fermented food enables waste-to-food conversion Open
Fungal fermentation of food and agricultural by-products holds promise for improving food sustainability and security. However, the molecular basis of fungal waste-to-food upcycling remains poorly understood. Here we use a multi-omics appr…
View article: Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era
Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era Open
Natural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification and biosynthetic origins, and the microbiological an…
View article: Multi-omics analysis of a traditional fermented food reveals a byproduct-associated subpopulation of<i>Neurospora intermedia</i>for waste-to-food upcycling
Multi-omics analysis of a traditional fermented food reveals a byproduct-associated subpopulation of<i>Neurospora intermedia</i>for waste-to-food upcycling Open
Fungal solid-state fermentation (SSF) of byproducts has promise for increasing food sustainability and security, but fungal waste-to-food upcycling remains poorly understood at the molecular level. Here we use a multi-omics approach to cha…
View article: Argonaute and Dicer are essential for communication between <i>Trichoderma atroviride</i> and fungal hosts during mycoparasitism
Argonaute and Dicer are essential for communication between <i>Trichoderma atroviride</i> and fungal hosts during mycoparasitism Open
Trichoderma species are known for their mycoparasitic activity against phytopathogenic fungi that cause significant economic losses in agriculture. During mycoparasitism, Trichoderma spp. recognize molecules produced by the host fungus and…
View article: GastronOmics: Edibility and safety of mycelium of the oyster mushroom Pleurotus ostreatus
GastronOmics: Edibility and safety of mycelium of the oyster mushroom Pleurotus ostreatus Open
Food production is one of the most environmentally damaging human activities. In the face of climate change, it is essential to rethink our dietary habits and explore potential alternative foods catering both towards human and planetary ne…
View article: Systems Toxicology Studies Reveal Important Insights About Chronic Exposure of Zebrafish to Kalanchoe Pinnata (Lam.) Pers Leaf - Kpl: Implications for Medicinal Use
Systems Toxicology Studies Reveal Important Insights About Chronic Exposure of Zebrafish to Kalanchoe Pinnata (Lam.) Pers Leaf - Kpl: Implications for Medicinal Use Open
View article: Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18
Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18 Open
Penicillium setosum represents a Penicillium species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of P. setosum CMLD…
View article: Molecular Dereplication and In Vitro and In Silico Pharmacological Evaluation of Coriandrum sativum against Neuroblastoma Cells
Molecular Dereplication and In Vitro and In Silico Pharmacological Evaluation of Coriandrum sativum against Neuroblastoma Cells Open
The aim of this study was to investigate the cytotoxic activity of the Coriandrum sativum (C. sativum) ethanolic extract (CSEE) in neuroblastoma cells, chemically characterize the compounds present in the CSEE, and predict the molecular in…
View article: Anacardic Acid Derivatives Affect the<i>in Vitro</i>Reactions of Photosynthesis
Anacardic Acid Derivatives Affect the<i>in Vitro</i>Reactions of Photosynthesis Open
The dichloromethane extract of the cashew nuts from Anacardium occidentale was fractionated by rotation locular countercurrent chromatography aimed at discovering metabolites that could be useful as new models for photosynthesis inhibitors…
View article: The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish
The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish Open
Bryophyllum pinnatum (Lam.) Oken (BP) is a plant that is used worldwide to treat inflammation, infections, anxiety, restlessness, and sleep disorders. While it is known that BP leaves are rich in flavonoids, the extent of the beneficial an…
View article: The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish
The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish Open
Bryophyllum pinnatum (Lam.) Oken (BP) is a plant that is used worldwide to treat inflammation, infections, anxiety, restlessness, and sleep disorders. While it is known that BP leaves are rich in flavonoids, the extent of the beneficial an…
View article: Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations
Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations Open
Objective. This in vitro study evaluated the influence of bioactive plant extracts as dentin biomodifying agents to improve the longevity of bonded restorations. For that, plant extracts were applied to the dentin surface prior to the adhe…
View article: Integrated Analytical Tools for Accessing Acridones and Unrelated Phenylacrylamides from Swinglea glutinosa
Integrated Analytical Tools for Accessing Acridones and Unrelated Phenylacrylamides from Swinglea glutinosa Open
In natural product studies, the purification of metabolites is an important challenge. To accelerate this step, alternatives such as integrated analytical tools should be employed. Based on this, the chemical study of Swinglea glutinosa (R…
View article: Fluorescence of Chlorophyll &lt;i&gt;a&lt;/i&gt; for Discovering Inhibitors of Photosynthesis in Plant Extracts
Fluorescence of Chlorophyll <i>a</i> for Discovering Inhibitors of Photosynthesis in Plant Extracts Open
Aims: Twelve crude extracts were prepared from different parts of Pluchea sagittalis, Cecropia palmata and Brachiaria brizantha, and their effect on the light reaction of photosynthesis. Study Design: Use of fluorescence of ChL a (Chloroph…