Ana Carolina Morandini
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View article: Adenosine A2a Receptor Stimulation Mitigates Periodontitis and Is Mitoprotective in Gingival Fibroblasts Promoting Cellular Resilience
Adenosine A2a Receptor Stimulation Mitigates Periodontitis and Is Mitoprotective in Gingival Fibroblasts Promoting Cellular Resilience Open
Adenosine signaling plays protective roles in gingival mitochondrial health and inflammation control, with the ectoenzyme CD73 implicated in periodontitis. Here, we investigated the effects of selective adenosine A2a receptor (A2aR) stimul…
View article: Ectodermal dysplasia: a narrative review of the clinical and biological aspects relevant to oral health
Ectodermal dysplasia: a narrative review of the clinical and biological aspects relevant to oral health Open
Ectodermal dysplasias (ED) are disorders that affect ectodermal-derived tissues during embryonic development. These disorders occur when the ectoderm, the outermost layer of embryonic tissue does not develop normally. Patients present abno…
View article: Adenosine A2a receptor in Experimental Periodontitis
Adenosine A2a receptor in Experimental Periodontitis Open
OBJECTIVES: Our previous work has shown the role of adenosine in mitochondrial health to regulate IL-1-mediated inflammation in human gingival fibroblasts, and the protective role of enzyme CD73, which is the final step to generate adenosi…
View article: The Effect of Palmitate in the Expression of Ectonucleotidase CD73 and Inflammatory Markers in Murine Gingival Fibroblasts
The Effect of Palmitate in the Expression of Ectonucleotidase CD73 and Inflammatory Markers in Murine Gingival Fibroblasts Open
OBJECTIVES: The goal of this study is to observe the effect of palmitate in the pro-inflammatory response of murine gingival fibroblasts in vitro and the levels of purine metabolizing enzyme CD73 which can ultimately control inflammation t…
View article: Mitochondrial function in oral health and disease
Mitochondrial function in oral health and disease Open
Monitoring mitochondrial function and mitochondrial quality control in tissues is a crucial aspect of understanding cellular health and dysfunction, which may inform about the pathogenesis of several conditions associated with aging, inclu…
View article: The protective role of CD73 in periodontitis: preventing hyper-inflammatory fibroblasts and driving osteoclast energy metabolism
The protective role of CD73 in periodontitis: preventing hyper-inflammatory fibroblasts and driving osteoclast energy metabolism Open
Introduction Periodontitis is an immune-mediated inflammatory disease affecting almost half of the adult population and is the leading cause of tooth loss in the United States. The role of extracellular nucleotide signaling including nucle…
View article: Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease
Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease Open
EDITORIAL article Front. Oral. Health, 16 June 2023Sec. Oral Infections and Microbes Volume 4 - 2023 | https://doi.org/10.3389/froh.2023.1236507
View article: Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state
Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state Open
Introduction Fibroblasts are the dominant stromal cells in the gingival lamina propria with a well-established relevance in regulation of inflammation, and in innate immunity. This is exemplified by their hypersecretion of CXCL8, enhancing…
View article: Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging Open
Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have …
View article: Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging Open
Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have …
View article: Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice Open
As the aging population grows, chronic age-related bone degenerative diseases become more prevalent and severe. One such disease, periodontitis (PD), rises to 70.1% prevalence in Americans 65 years and older. PD has been linked to increase…
View article: Dendritic cells a critical link to alveolar bone loss and systemic disease risk in periodontitis: Immunotherapeutic implications
Dendritic cells a critical link to alveolar bone loss and systemic disease risk in periodontitis: Immunotherapeutic implications Open
Extensive research in humans and animal models has begun to unravel the complex mechanisms that drive the immunopathogenesis of periodontitis. Neutrophils mount an early and rapid response to the subgingival oral microbiome, producing dest…
View article: Editorial: Oral Microbiome and Inflammation Connection to Systemic Health
Editorial: Oral Microbiome and Inflammation Connection to Systemic Health Open
ANID/Chilean National Fund for Scientific and Technologic Development (FONDECYT)\t11180505\t
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\nUnited States Department of Health & Human Services
\nNational Institutes of Health (NIH) - USA
\nNIH National I…
View article: Selective Antimicrobial Therapies for Periodontitis: Win the “Battle and the War”
Selective Antimicrobial Therapies for Periodontitis: Win the “Battle and the War” Open
Traditional antimicrobial therapies for periodontitis (PD) have long focused on non-selective and direct approaches. Professional cleaning of the subgingival biofilm by instrumentation of dental root surfaces, known as scaling and root pla…
View article: CD73‐dependent adenosine dampens interleukin‐1β–induced CXCL8 production in gingival fibroblasts: Association with heme oxygenase‐1 and adenosine monophosphate‒activated protein kinase
CD73‐dependent adenosine dampens interleukin‐1β–induced CXCL8 production in gingival fibroblasts: Association with heme oxygenase‐1 and adenosine monophosphate‒activated protein kinase Open
Background During inflammation, stressed or infected cells can release adenosine triphosphate (ATP) to the extracellular medium, which can be hydrolyzed to adenosine by ectonucleotidases such as ectonucleoside triphosphate diphosphohydrola…
View article: The role of Aryl Hydrocarbon Receptor (AhR) signaling pathway in oral squamous cell carcinoma (OSCC): preliminary results.
The role of Aryl Hydrocarbon Receptor (AhR) signaling pathway in oral squamous cell carcinoma (OSCC): preliminary results. Open
OBJECTIVES: A large number of experimental and clinical studies suggest that the origin of oral squamous cell carcinoma (OSCC) is linked to environmental carcinogenesis (tobacco, alcohol). Among these environmental factors, cigarette smoki…
View article: Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin‐1β‐Induced Cytokines in Human Periodontal Fibroblasts
Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin‐1β‐Induced Cytokines in Human Periodontal Fibroblasts Open
Background: The renin‐angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1‐7/Mas receptor axis as counter‐regulatory to the classic RAS Ang …
View article: Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling
Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling Open
Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of host defenses that can lead to a more prominent immune response and shape the course of inflammation in the host. Thus, the epigenetics can both drive t…