Ana Catalina Hernandez Padilla
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View article: Longitudinal three-year comparative genomic analysis of Pseudomonas aeruginosa respiratory isolates from mechanically ventilated intensive care unit patients
Longitudinal three-year comparative genomic analysis of Pseudomonas aeruginosa respiratory isolates from mechanically ventilated intensive care unit patients Open
Background: Pseudomonas aeruginosa is a common pathogen involved in ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients. Our primary objective was to characterize and compare the genomes of consecutive P. aeruginosa…
View article: Evolution of Tracheobronchial Colonization Following Tracheal Intubation in Patients With Neurologic Injury Who Are Ventilated
Evolution of Tracheobronchial Colonization Following Tracheal Intubation in Patients With Neurologic Injury Who Are Ventilated Open
International audience
View article: Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response
Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response Open
Septic patients with worst clinical prognosis have increased circulating immature granulocytes (IG), displaying limited phagocytosis and reactive oxygen species (ROS) production. Here, we developed an ex vivo model of incubation of …
View article: Are monoclonals the way forward to prevent or to treat ventilator-associated pneumonia in the intensive care unit?
Are monoclonals the way forward to prevent or to treat ventilator-associated pneumonia in the intensive care unit? Open
KEYWORDS: Antibiotic resistanceintensive care unitpreventionmonoclonal antibodiesventilator-associated pneumoniavirulence
View article: Effet de la réponse inflammatoire à la phase aigüe du sepsis sur l’induction de la réponse SOS bactérienne
Effet de la réponse inflammatoire à la phase aigüe du sepsis sur l’induction de la réponse SOS bactérienne Open
Sepsis is defined as a dysregulated immune response to infection, and in severe cases is associated to an increase in the proportion of circulating Immature Granulocytes (IG), secondary to an emergency granulopoiesis. Pathogen control func…
View article: Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases
Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases Open
View article: Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study
Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study Open
We investigated the performance of the Xpert methicillin-resistant Staphylococcus aureus (MRSA)/ S. aureus skin and soft tissue (SSTI) quantitative PCR (qPCR) assay in SAATELLITE, a multicenter, double-blind, phase 2 study of suvratoxumab,…
View article: High prevalence of infections in non-COVID-19 patients admitted to the Emergency Department with severe lymphopenia
High prevalence of infections in non-COVID-19 patients admitted to the Emergency Department with severe lymphopenia Open
View article: Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia Open
View article: Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial
Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial Open
View article: 2839. Efficacy, Pharmacokinetics (PK), and Safety Profile of Suvratoxumab (MEDI4893), a Staphylococcus aureus Alpha Toxin (AT)-Neutralizing Human Monoclonal Antibody in Mechanically Ventilated Patients in Intensive Care Units; Results of the Phase 2 SAATELLITE Study Conducted by the Public-Private COMBACTE Consortium
2839. Efficacy, Pharmacokinetics (PK), and Safety Profile of Suvratoxumab (MEDI4893), a Staphylococcus aureus Alpha Toxin (AT)-Neutralizing Human Monoclonal Antibody in Mechanically Ventilated Patients in Intensive Care Units; Results of the Phase 2 SAATELLITE Study Conducted by the Public-Private COMBACTE Consortium Open
Background Staphylococcus aureus (SA) pneumonia imposes significant morbidity and mortality in mechanically ventilated, intensive care unit (MV ICU) patients despite best clinical care. We assessed efficacy, PK, AT-neutralizing antibodies …
View article: 2160. Performance of the Cepheid Rapid PCR Test for Patient Screening and Association with Efficacy of Suvratoxumab, A Novel Anti-Staphylococcus aureus Monoclonal Antibody, During the Phase 2 SAATELLITE study
2160. Performance of the Cepheid Rapid PCR Test for Patient Screening and Association with Efficacy of Suvratoxumab, A Novel Anti-Staphylococcus aureus Monoclonal Antibody, During the Phase 2 SAATELLITE study Open
Background Patients with lower airway Staphylococcus aureus (SA) colonization are at great risk (> 20%) of early-onset ventilator-associated pneumonia (VAP). Thus, a rapid test is required to identify patients at risk. Suvratoxumab (former…
View article: Comparative Early Hemodynamic Profiles in Patients Presenting to the Emergency Department with Septic and Nonseptic Acute Circulatory Failure Using Focused Echocardiography
Comparative Early Hemodynamic Profiles in Patients Presenting to the Emergency Department with Septic and Nonseptic Acute Circulatory Failure Using Focused Echocardiography Open
Study Objective: We evaluated the early hemodynamic profile of patients presenting with acute circulatory failure to the Emergency Department (ED) using focused echocardiography performed by emergency physicians after a dedicated training …
View article: Community-acquired Staphylococcus aureus bacteriuria: a warning microbiological marker for infective endocarditis?
Community-acquired Staphylococcus aureus bacteriuria: a warning microbiological marker for infective endocarditis? Open
View article: Is prehospital endobronchial intubation a risk factor for subsequent ventilator associated pneumonia? A retrospective analysis
Is prehospital endobronchial intubation a risk factor for subsequent ventilator associated pneumonia? A retrospective analysis Open
More than half of patients under mechanical ventilation in the intensive care unit (ICU) are field-intubated, which is a known risk factor for ventilator associated pneumonia (VAP). We assessed whether field endobronchial intubation (EBI) …
View article: Serum levels of S100B from jugular bulb as a biomarker of poor prognosis in patients with severe acute brain injury
Serum levels of S100B from jugular bulb as a biomarker of poor prognosis in patients with severe acute brain injury Open
Regional protein S100B determinations are higher than systemic determinations, thus confirming the cerebral origin of protein S100B. The transcranial protein S100B gradient is correlated to the development of brain death.