Ana Checa-Ros
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View article: Molecular mechanisms linking adipose tissue browning to reduced cardiovascular risk
Molecular mechanisms linking adipose tissue browning to reduced cardiovascular risk Open
Recent research elucidates the complex molecular mechanisms linking adipose tissue (AT) browning to improved metabolic and cardiovascular health. Pro-inflammatory signaling pathways, such as NLRP3 inflammasome, TLR4, and NF-κB, typically i…
View article: C-peptide and epicardial adipose tissue in dialysis-dependent chronic kidney disease patients
C-peptide and epicardial adipose tissue in dialysis-dependent chronic kidney disease patients Open
Background Several studies suggest that C-peptide (CP) is involved in regulating lipolysis, adipokine release, and other functions in the adipose tissue. On the other hand, organ-specific adipose tissues, such as the epicardial adipose tis…
View article: Novel Pathogenic Genotype in <scp><i>SLC12A3</i></scp> Associated to Gitelman Syndrome: A Case Report
Novel Pathogenic Genotype in <span><i>SLC12A3</i></span> Associated to Gitelman Syndrome: A Case Report Open
Gitelman syndrome (GS) is considered one of the most common hereditary renal tubular disorders, characterised by hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. The primary cause of this disorder resides in the SLC12A3…
View article: SGLT2 Inhibitors: Multifaceted Therapeutic Agents in Cardiometabolic and Renal Diseases
SGLT2 Inhibitors: Multifaceted Therapeutic Agents in Cardiometabolic and Renal Diseases Open
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is), initially developed as antihyperglycemic agents, have emerged as multifunctional therapeutics with profound cardiorenal and metabolic benefits. Their unique insulin-independe…
View article: Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study
Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study Open
Introduction Chronic kidney disease (CKD) patients show high rates of cardiovascular disease (CVD) and mortality. In the general population, obesity, hypertension, and diabetes are known as the classical CVD risk factors. However, CKD pati…
View article: In silico medicine and -omics strategies in nephrology: contributions and relevance to the diagnosis and prevention of chronic kidney disease
In silico medicine and -omics strategies in nephrology: contributions and relevance to the diagnosis and prevention of chronic kidney disease Open
Chronic kidney disease (CKD) has been increasing over the last years, with a rate between 0.49% to 0.87% new cases per year. Currently, the number of affected people is around 850 million worldwide. CKD is a slowly progressive disease that…
View article: Differences in the Interleukin Profiles in Inattentive ADHD Prepubertal Children Are Probably Related to Conduct Disorder Comorbidity
Differences in the Interleukin Profiles in Inattentive ADHD Prepubertal Children Are Probably Related to Conduct Disorder Comorbidity Open
Inflammatory cytokines are involved in attention deficit hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder. To quantify the baseline levels of pro- and anti-inflammatory cytokines and their changes after methylp…
View article: #2061 Perirenal fat thickness as a potential marker for cardiovascular risk in chronic kidney disease: the influence of vitamin D analogs
#2061 Perirenal fat thickness as a potential marker for cardiovascular risk in chronic kidney disease: the influence of vitamin D analogs Open
Background and Aims Patients with CKD show high cardiovascular complication rates. There are classical cardiovascular risk factors, such as obesity, dyslipidemia, and diabetes; however, other cardiovascular disease risk factors are associa…
View article: Epidemiological behavior of childhood obesity: A continental point of view
Epidemiological behavior of childhood obesity: A continental point of view Open
Weight excess during the childhood has been one of the most critical public health problems worldwide in the past few decades. It is considered a significant predictor of adulthood obesity, increased cardiometabolic diseases, and premature…
View article: Differences in the Interleukins profile in Inatentive-ADHD prepubertal children are probably related to comorbidities
Differences in the Interleukins profile in Inatentive-ADHD prepubertal children are probably related to comorbidities Open
Background. Inflammatory cytokines are involved in attention deficit/hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder. Objetive. To quantify baseline levels of pro- and anti-inflammatory cytokines and their cha…
View article: Pancreatic and Hepatic Injury in COVID-19: A Worse Prognosis in NAFLD Patients?
Pancreatic and Hepatic Injury in COVID-19: A Worse Prognosis in NAFLD Patients? Open
The novel disease produced by SARS-CoV-2 mainly harms the respiratory tract, but it has shown the capacity to affect multiple organs. Epidemiologic evidence supports the relationship between Coronavirus Disease 2019 (COVID-19) and pancreat…
View article: Obesity and Oral Health: The Link Between Adipokines and Periodontitis
Obesity and Oral Health: The Link Between Adipokines and Periodontitis Open
Periodontitis is a chronic inflammatory disease of the periodontium, or the supportive tissues around the tooth. This disease has been related to different risk factors, such as the presence of plaque and calculus, tobacco smoking, low soc…
View article: The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective
The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective Open
During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose to the foetus. These metabolic modifications develop what is known as physiological insulin resistance. When this process is altered, howe…
View article: Exploring the Link between Cardiorenal and Metabolic Diseases
Exploring the Link between Cardiorenal and Metabolic Diseases Open
The close link between metabolic diseases, such as obesity and diabetes mellitus, and cardiorenal disease can be attributed not only to direct risk factors, such as hypertension, but also to the intricate interplay of various pathophysiolo…
View article: The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis
The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis Open
Cancer is a process involving cell mutation, increased proliferation, invasion, and metastasis. Over the years, this condition has represented one of the most concerning health problems worldwide due to its significant morbidity and mortal…
View article: Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial
Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial Open
Objective. Only a few studies assessing the sleep effects of low doses of melatonin (aMT) have been performed in the past, most of them in adults, and only one in subjects with attention-deficit/hyperactivity disorder (ADHD). The aim of th…
View article: Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)
Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT) Open
Background: Chronic kidney disease (CKD) is a common complication of a non-kidney solid organ transplant (NKSOT). Identifying predisposing factors is crucial for an early approach and correct referral to nephrology. Methods: This is a sing…
View article: Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)
Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT) Open
Background: Chronic kidney disease (CKD) is a common complication of non-kidney solid organ transplant (NKSOT). Identifying predisposing factors is crucial for an early approach and correct referral to nephrology. Methods: This is a single…
View article: Is S100B Involved in Attention-Deficit/Hyperactivity Disorder (ADHD)? Comparisons with Controls and Changes Following a Triple Therapy Containing Methylphenidate, Melatonin and ω-3 PUFAs
Is S100B Involved in Attention-Deficit/Hyperactivity Disorder (ADHD)? Comparisons with Controls and Changes Following a Triple Therapy Containing Methylphenidate, Melatonin and ω-3 PUFAs Open
Background: Increasing evidence supports a neuroinflammatory basis in ADHD damaging glial function and thereby altering dopaminergic (DA) neurotransmission. Previous studies focusing on the S100B protein as a marker of glial function have …
View article: Etelcalcetide and Paricalcitol in Chronic Kidney Disease: When the Target Is Inflammation
Etelcalcetide and Paricalcitol in Chronic Kidney Disease: When the Target Is Inflammation Open
Introduction: secondary hyperparathyroidism (SHP) is frequent in patients with chronic kidney disease (CKD), particularly in those in dialysis. To treat this complication, the current options available include phosphorus restriction, phosp…
View article: Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers
Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers Open
Omega-3 fatty acids (ω-3 FAs) are well-known for their actions on immune/inflammatory and neurological pathways, functions that are also under circadian clock regulation. The daily photoperiod represents the primary circadian synchronizer …
View article: Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children
Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children Open
View article: Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications
Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications Open
Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome–gut–brain axis (MGBA), is involved in diverse neuropsychiatric diseases in child…
View article: Indole Tryptophan Metabolism and Cytokine S100B in Children with Attention-Deficit/Hyperactivity Disorder: Daily Fluctuations, Responses to Methylphenidate, and Interrelationship with Depressive Symptomatology
Indole Tryptophan Metabolism and Cytokine S100B in Children with Attention-Deficit/Hyperactivity Disorder: Daily Fluctuations, Responses to Methylphenidate, and Interrelationship with Depressive Symptomatology Open
Background: Indole tryptophan metabolites (ITMs), mainly produced at the gastrointestinal level, participate in bidirectional gut-brain communication and have been implicated in neuropsychiatric pathologies, including attenti…
View article: Clinical Considerations Derived From the Administration of Melatonin to Children With Sleep Disorders
Clinical Considerations Derived From the Administration of Melatonin to Children With Sleep Disorders Open
View article: Automedicación, autoprescripción y medicación «por poderes» en pediatría
Automedicación, autoprescripción y medicación «por poderes» en pediatría Open
Self-prescribing or medicating 'by proxy' is not an autonomous, free and voluntary decision in the case of children. On the contrary, in this case it is based on the subjective interpretation of symptoms made by the mother or by a third pe…