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View article: Quantifying viral load and characterizing virus diversity in wildlife samples with target enrichment sequencing
Quantifying viral load and characterizing virus diversity in wildlife samples with target enrichment sequencing Open
Metagenomics is a powerful tool for characterizing viruses, with broad applications across diverse disciplines, from understanding the ecology and evolutionary history of viruses to identifying causative agents of emerging outbreaks with u…
View article: Clinical effectiveness, safety, and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomized Phase III trial
Clinical effectiveness, safety, and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomized Phase III trial Open
Early community treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may reduce severe coronavirus disease (COVID-19) incidence. We evaluated clinical effectiveness, safety, and SARS-CoV-2 mutagenicity of fav…
View article: Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement
Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement Open
Influenza A viruses (IAVs) are prime examples of emerging viruses in humans and animals. IAV circulation in domestic animals poses a pandemic risk as it provides new opportunities for zoonotic infections. The recent emergence of H5N1 IAV i…
View article: Quantifying virus load and characterising virus diversity in wildlife samples with target enrichment sequencing
Quantifying virus load and characterising virus diversity in wildlife samples with target enrichment sequencing Open
Metagenomics is a powerful tool for characterising viruses, with broad applications across diverse disciplines, from understanding the ecology and evolutionary history of viruses to identifying causative agents of emerging outbreaks with u…
View article: Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing
Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing Open
View article: ANÁLISE COMPARATIVA DE ELEMENTOS ESTRUTURAIS DO PISO DE BOX MODULARES UTILIZANDO AÇO SAE 1010 E USI SAC 300
ANÁLISE COMPARATIVA DE ELEMENTOS ESTRUTURAIS DO PISO DE BOX MODULARES UTILIZANDO AÇO SAE 1010 E USI SAC 300 Open
A construção civil é um dos seguimentos econômicos representativos em um país, contudo enfrenta desafios como produtividade, desperdício de materiais e déficit habitacional. A construção modular é uma metodologia construtiva de suma import…
View article: Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic Open
SARS-CoV-2 variants are mainly defined by mutations in their spike. It is therefore critical to understand how the evolutionary trajectories of spike affect virus phenotypes. So far, it has been challenging to comprehensively compare the m…
View article: Comparative study of two Rift Valley fever virus field strains originating from Mauritania
Comparative study of two Rift Valley fever virus field strains originating from Mauritania Open
Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), the causative agent of RVF, has been responsible for multiple outbreaks in West Africa with important consequences o…
View article: POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS
POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS Open
H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has caused, unexpectedly, a large outbreak in dairy cattle in North America. It is critical to ascertain how this virus has specifically adapted to bovine cells and the molecula…
View article: The 2023 South Sudanese outbreak of Hepatitis E emphasizes ongoing circulation of genotype 1 in North, Central, and East Africa
The 2023 South Sudanese outbreak of Hepatitis E emphasizes ongoing circulation of genotype 1 in North, Central, and East Africa Open
View article: Correlates of disease severity in bluetongue as a model of acute arbovirus infection
Correlates of disease severity in bluetongue as a model of acute arbovirus infection Open
Most viral diseases display a variable clinical outcome due to differences in virus strain virulence and/or individual host susceptibility to infection. Understanding the biological mechanisms differentiating a viral infection displaying s…
View article: Widespread human exposure to ledanteviruses in Uganda: A population study
Widespread human exposure to ledanteviruses in Uganda: A population study Open
Le Dantec virus (LDV), assigned to the species Ledantevirus ledantec , genus Ledantevirus , family Rhabdoviridae has been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human ca…
View article: Hepatitis C virus diversity and treatment outcomes in Benin: a prospective cohort study
Hepatitis C virus diversity and treatment outcomes in Benin: a prospective cohort study Open
Medical Research Council, Wellcome, Global Challenges Research Fund, Academy of Medical Sciences, and PHARMBIOTRAC.
View article: Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic Open
Variants of SARS-CoV-2, defined mainly by mutations in the spike glycoprotein, have emerged throughout the COVID-19 pandemic and will undoubtedly continue to emerge in the future. Spike strongly influences virus phenotype, and it is theref…
View article: Viruses associated with measles-like illnesses in Uganda
Viruses associated with measles-like illnesses in Uganda Open
The study highlights the presence of undiagnosed viruses causing MLI in Uganda, including vaccine-preventable illnesses. NGS can be used to monitor common viral infections at a population level, especially in regions where such infections …
View article: Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel
Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel Open
Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), the causative agent of RVF, has been responsible for multiple outbreaks in West Africa with important consequences o…
View article: A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection
A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection Open
Most viral diseases display a variable clinical outcome due to differences in virus strain virulence and/or individual host susceptibility to infection. Understanding the biological mechanisms differentiating a viral infection displaying s…
View article: Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome Open
Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs inter…
View article: Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 Open
Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infectio…
View article: Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome Open
Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs inter…
View article: Suspected tick‐borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021)
Suspected tick‐borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021) Open
Objectives Tick‐borne encephalitis virus and louping ill virus are neurotropic flaviviruses transmitted by ticks. Epidemiologically, tick‐borne encephalitis is endemic in Europe whereas louping ill's predominant geographical distribution i…
View article: Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning
Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve throughout the coronavirus disease-19 (COVID-19) pandemic, giving rise to multiple variants of concern (VOCs) with different biological properties. As the…
View article: Mosquito virus diversity in Western and North-western Uganda
Mosquito virus diversity in Western and North-western Uganda Open
Introduction Surveillance for mosquito borne arboviruses in Sub Saharan Africa has largely focussed on known viruses including Yellow fever virus (YFV), Rift Valley fever virus (RVFV), Chikungunya virus (CHIKV), West Nile virus (WNV) and D…
View article: Widespread human exposure to ledanteviruses in Uganda – a population study
Widespread human exposure to ledanteviruses in Uganda – a population study Open
Le Dantec virus (LDV), type species of the genus Ledantevirus within the Rhabdoviridae has been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human case of undifferentiated fev…
View article: Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV
Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV Open
Fever is an evolutionary conserved host pro-inflammatory immune response that governs the regulation of multiple biological processes to control the outcome of infection. In January 2022, the World Health Organization (WHO) reported a glob…
View article: Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera Open
The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has provided crucial protection ag…
View article: Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis)
Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis) Open
Distinct cytomegaloviruses (CMVs) are widely distributed across their mammalian hosts in a highly host species-restricted pattern. To date, evidence demonstrating this has been limited largely to PCR-based approaches targeting small, conse…
View article: International Pediatric COVID-19 Severity Over the Course of the Pandemic
International Pediatric COVID-19 Severity Over the Course of the Pandemic Open
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear. Objective To determine whether the dominant circulating SARS-CoV-2 variants of conce…
View article: SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports
SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports Open
Although domestic cats are susceptible to infection with SARS-CoV-2, the role of the virus in causing feline disease is less well defined. We conducted a large-scale study to identify SARS-CoV-2 infections in UK pet cats, using active and …
View article: SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports
SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports Open
Although domestic cats are susceptible to infection with SARS-CoV-2, the role of the virus in causing feline disease is less well defined. We conducted a large-scale study to identify SARS-CoV-2 infections in UK pet cats, using active and …