Ana I. Fernández-Mariño
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View article: Structural basis of fast N-type inactivation in Kv channels
Structural basis of fast N-type inactivation in Kv channels Open
Action potentials are generated by opening of voltage-activated sodium (Na v ) and potassium (K v ) channels 1 , which can rapidly inactivate to shape the nerve impulse and contribute to synaptic facilitation and short-term memory 1–4 . Th…
View article: Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse
Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse Open
Eukaryotic voltage-gated K + channels have been extensively studied, but the structural bases for some of their most salient functional features remain to be established. C-type inactivation, for example, is an auto-inhibitory mechanism th…
View article: Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators Open
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activati…
View article: Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation Open
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory and is implicated in various human n…
View article: Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation Open
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory, and is implicated in various human …
View article: RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein
RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein Open
Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-…