Ana Martínez-Marchal
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View article: TRIP13 fosters both transcriptional silencing and DSB repair during meiosis
TRIP13 fosters both transcriptional silencing and DSB repair during meiosis Open
During meiosis, the coordinated suppression of global gene transcription and induction of double-strand breaks (DSBs) genome wide is crucial for successful gamete formation. The AAA+ ATPase TRIP13 is a master meiotic regulator involved in …
View article: Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro maturation within a single sample
Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro maturation within a single sample Open
Recently, we described that in the naked mole rat ovary it is possible to study the ovarian reserve and the mitotic expansion of the germ cell postnatally. Herein, we show oocyte in vitro maturation and in vitro germ cell expansion using t…
View article: High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients
High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients Open
View article: SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes
SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes Open
Although much has been published since the first cases of COVID-19, there remain unanswered questions regarding SARS-CoV-2 impact on testes and the potential consequences for reproductive health. We investigated testicular alterations in d…
View article: Genetic insights into biological mechanisms governing human ovarian ageing
Genetic insights into biological mechanisms governing human ovarian ageing Open
View article: Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin
Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin Open
Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via the bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection by SARS…
View article: Genetic insights into the biological mechanisms governing human ovarian ageing
Genetic insights into the biological mechanisms governing human ovarian ageing Open
Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian a…
View article: The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice
The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice Open
Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) caus…
View article: The DNA damage response regulates the oocyte pool in mammals
The DNA damage response regulates the oocyte pool in mammals Open
Summary Mammalian oogonia proliferate without completing cytokinesis producing germ cell cysts. Within these cysts, oocytes differentiate and enter meiosis, promote genome-wide double-strand break (DSBs) formation which repair by homologou…
View article: ATR is required to complete meiotic recombination in mice
ATR is required to complete meiotic recombination in mice Open
View article: p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes Open
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene sta…
View article: ATR is required to complete meiotic recombination in mice
ATR is required to complete meiotic recombination in mice Open
Precise execution of recombination during meiosis is essential for forming chromosomally balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). Binding of replication protein …
View article: CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination
CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination Open
CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate th…