Ana Cecília A. Roque
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View article: Discovery and optimization of a synthetic small protein domain targeting antibodies
Discovery and optimization of a synthetic small protein domain targeting antibodies Open
Introduction Antibodies and their derivatives constitute a crucial class of molecules in modern biotechnology and therapeutic development. Consequently, identifying chemically robust affinity ligands capable of specifically recognizing ant…
View article: Random and unpredictable optical textures in biobased self-assembled ionogels for dynamic anti-counterfeiting tags
Random and unpredictable optical textures in biobased self-assembled ionogels for dynamic anti-counterfeiting tags Open
Physical unclonable function (PUF) tags generated through stochastic processes yield unique identifiers, providing secure anti-counterfeiting mechanisms for product authentication and tracking. The widespread use of PUF tags also poses env…
View article: Effect of physical exercise on taste perception and saliva composition: An exploratory study
Effect of physical exercise on taste perception and saliva composition: An exploratory study Open
Physical exercise has known physiological effects. Although it is empirically assumed that these effects extend to changes in salivation and even in appetite, the influence of exercise on oral biochemistry - and its potential interplay wit…
View article: Non-invasive bladder cancer detection: Identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning
Non-invasive bladder cancer detection: Identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning Open
Early detection of bladder cancer (BC) remains a major clinical challenge due to the limitations of current diagnostic methods, which are often invasive, expensive, or insufficiently sensitive, particularly for early-stage disease. Metabol…
View article: Design and evolution of a synthetic small protein scaffold based on the <scp>WW</scp> domain
Design and evolution of a synthetic small protein scaffold based on the <span>WW</span> domain Open
Protein engineering is a powerful tool in biotechnology and the basis to create unprecedented sequences, structures, and functions. The WW domains are a family of naturally occurring proteins involved in the molecular recognition of prolin…
View article: Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein
Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein Open
Viral infections represent a global health threat, causing three million deaths annually. Antiviral strategies primarily target viral genome replication or prevent virus entry into host cells. While most FDA-approved antiviral drugs are sm…
View article: Kinetics of charge-dependent reversible condensation of reflectin nanostructures
Kinetics of charge-dependent reversible condensation of reflectin nanostructures Open
Recombinant reflectin proteins reversibly condense in vitro with pH changes. The kinetics assembly is sequence dependent and is essential for designing reflectin-based biophotonic materials.
View article: Correction: Oliveira et al. Effect of Polymer Hydrophobicity in the Performance of Hybrid Gel Gas Sensors for E-Noses. Sensors 2023, 23, 3531
Correction: Oliveira et al. Effect of Polymer Hydrophobicity in the Performance of Hybrid Gel Gas Sensors for E-Noses. Sensors 2023, 23, 3531 Open
In the published publication [...]
View article: Short Peptide and Amino Acid‐Based Supramolecular Ionogels and Eutectogels
Short Peptide and Amino Acid‐Based Supramolecular Ionogels and Eutectogels Open
The capability of peptide and amino acid‐based molecules to act as ionogelators and eutectogelators entrapping ionic liquids (ILs) and deep eutectic solvents (DESs) forming ionogels and eutectogels has gathered attention in recent decades.…
View article: An odorant-binding protein based electrical sensor to detect volatile organic compounds
An odorant-binding protein based electrical sensor to detect volatile organic compounds Open
Artificial olfaction systems, such as electronic nose devices (ENs), can be used in various fields, from healthcare to food industry and the environmental sector. ENs consist of an array of sensors composed of different sensing materials. …
View article: Hierarchical self-assembly of a reflectin-derived peptide
Hierarchical self-assembly of a reflectin-derived peptide Open
Reflectins are a family of intrinsically disordered proteins involved in cephalopod camouflage, making them an interesting source for bioinspired optical materials. Understanding reflectin assembly into higher-order structures by standard …
View article: Impact of the Cationic Moiety of Ionic Liquids on Chemoselective Artificial Olfaction
Impact of the Cationic Moiety of Ionic Liquids on Chemoselective Artificial Olfaction Open
Ionogels and derived materials are assemblies of polymers and ionic liquids characterized by high stability and ionic conductivity, making them interesting choices as gas sensors. In this work, we assessed the effect of the ionic liquid mo…
View article: Effect of Polymer Hydrophobicity in the Performance of Hybrid Gel Gas Sensors for E-Noses
Effect of Polymer Hydrophobicity in the Performance of Hybrid Gel Gas Sensors for E-Noses Open
Relative humidity (RH) is a common interferent in chemical gas sensors, influencing their baselines and sensitivity, which can limit the performance of e-nose systems. Tuning the composition of the sensing materials is a possible strategy …
View article: Textural landscapes of VOC-sensitive chiral liquid crystal-based materials
Textural landscapes of VOC-sensitive chiral liquid crystal-based materials Open
Liquid crystal-based materials, in which liquid crystal molecules are confined and ordered in compartments, are dynamic materials yielding a variety of optical textures that can be tuned as a response to physical and chemical stimuli. Whil…
View article: A room temperature 9CB‐based chemical sensor
A room temperature 9CB‐based chemical sensor Open
The gas sensing potential of the 9CB (4‐cyano‐4′‐nonylbiphenyl) liquid crystal compound at ambient conditions is investigated. The solid at room temperature 9CB is incorporated in a hybrid gel formulation of ionic liquid/liquid crystal dro…
View article: Correction to “Nanoscale Events on Cyanobiphenyl-Based Self-Assembled Droplets Triggered by Gas Analytes”
Correction to “Nanoscale Events on Cyanobiphenyl-Based Self-Assembled Droplets Triggered by Gas Analytes” Open
Funding Information: This project has received funding by national funds from FCT–Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy–i4HB…
View article: Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
Solvent modulation in peptide sub-microfibers obtained by solution blow spinning Open
Peptides possess high chemical diversity at the amino acid sequence level, which further translates into versatile functions. Peptides with self-assembling properties can be processed into diverse formats giving rise to bio-based materials…
View article: Synergy between silk fibroin and ionic liquids for active gas-sensing materials
Synergy between silk fibroin and ionic liquids for active gas-sensing materials Open
Silk fibroin is a biobased material with excellent biocompatibility and mechanical properties, but its use in bioelectronics is hampered by the difficult dissolution and low intrinsic conductivity. Some ionic liquids are known to dissolve …
View article: Classification of Volatile Compounds with Morphological Analysis of e-nose Response
Classification of Volatile Compounds with Morphological Analysis of e-nose Response Open
LA/P/0140/2020 PD/BDE/142816/2018
View article: Incorporation of VOC-Selective Peptides in Gas Sensing Materials
Incorporation of VOC-Selective Peptides in Gas Sensing Materials Open
SCENT-ERC-2014-STG-639123, (2015-2022) LA/P/0140/2020
View article: Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity
Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity Open
Phage-display screening on self-assembled tyrosine-phosphate ligands enables the identification of oligopeptides selective to dynamic supramolecular targets, with the lead peptide showing a preferred hairpin-like conformation and catalytic…
View article: Tackling Humidity with Designer Ionic Liquid‐Based Gas Sensing Soft Materials
Tackling Humidity with Designer Ionic Liquid‐Based Gas Sensing Soft Materials Open
Relative humidity is simultaneously a sensing target and a contaminant in gas and volatile organic compound (VOC) sensing systems, where strategies to control humidity interference are required. An unmet challenge is the creation of gas‐se…
View article: Stable and Oriented Liquid Crystal Droplets Stabilized by Imidazolium Ionic Liquids
Stable and Oriented Liquid Crystal Droplets Stabilized by Imidazolium Ionic Liquids Open
Liquid crystals represent a fascinating intermediate state of matter, with dynamic yet organized molecular features and untapped opportunities in sensing. Several works report the use of liquid crystal droplets formed by microfluidics and …