Anabel Forte
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View article: Longitudinal Analysis in Mecp2-het Female Mice Reveals Atypical Nociceptive Behaviours
Longitudinal Analysis in Mecp2-het Female Mice Reveals Atypical Nociceptive Behaviours Open
Rett Syndrome (RTT), a neurodevelopmental disorder predominantly affecting females, is characterised by evolving symptoms impacting motor and sensory domains. Herein, we present a study of longitudinal analyses, from 2- to 6-month of age, …
View article: Proper 5’-3’ cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus
Proper 5’-3’ cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus Open
The budding yeast Xrn1 protein shuttles between the nucleus, where it stimulates transcription, and the cytoplasm, where it executes the major cytoplasmic mRNA decay. In the cytoplasm, apart from catalyzing 5’→3’ decay onto non translated …
View article: Model Uncertainty and Missing Data: An Objective Bayesian Perspective
Model Uncertainty and Missing Data: An Objective Bayesian Perspective Open
The interplay between missing data and model uncertainty -- two classic statistical problems -- leads to primary questions that we formally address from an objective Bayesian perspective. For the general regression problem, we discuss the …
View article: Screening the Discrepancy Function of a Computer Model
Screening the Discrepancy Function of a Computer Model Open
International audience
View article: A DIAGNOSIS APPROACH FROM DIFFERENT NATURE BIOMARKERS TO PREDICT THE ALZHEIMER DISEASE RISK
A DIAGNOSIS APPROACH FROM DIFFERENT NATURE BIOMARKERS TO PREDICT THE ALZHEIMER DISEASE RISK Open
Background Alzheimer Disease (AD) diagnosis requires invasive and expensive techniques (cerebrospinal fluid (CSF) biomarkers, neuroimaging), which could not be extended to general population. So, minimally‐invasive, specific and accurate A…
View article: Sex and age-dependent alterations of drug consumption during the COVID-19 lockdown in Spain: Lessons learned for the future
Sex and age-dependent alterations of drug consumption during the COVID-19 lockdown in Spain: Lessons learned for the future Open
In order to reduce the spread of COVID-19, lockdown has been one of the most implemented measures worldwide. Spain had one of the harshest lockdowns in Europe, impacting the social and psychological health of the population. The aim of thi…
View article: Does peer review improve the statistical content of manuscripts? A study on 27 467 submissions to four journals
Does peer review improve the statistical content of manuscripts? A study on 27 467 submissions to four journals Open
Improving the methodological rigour and the quality of data analysis in manuscripts submitted to journals is key to ensure the validity of scientific claims. However, there is scant knowledge of how manuscripts change throughout the review…
View article: Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2)
Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2) Open
The methyl-CpG binding protein 2 gene ( MECP2 ) encodes an epigenetic transcriptional regulator implicated in neuronal plasticity. Loss-of-function mutations in this gene are the primary cause of Rett syndrome and, to a lesser degree, of o…
View article: On the Design and Validation of Assessing Tools for Measuring the Impact of Programs Promoting STEM Vocations
On the Design and Validation of Assessing Tools for Measuring the Impact of Programs Promoting STEM Vocations Open
This paper presents the design and validation process of a set of instruments to evaluate the impact of an informal learning initiative to promote Science, Technology, Engineering, and Mathematics (STEM) vocations in students, their famili…
View article: Subsurface swimming and stationary diving are metabolically cheap in adult Pacific walruses (<i>Odobenus rosmarus divergens</i>)
Subsurface swimming and stationary diving are metabolically cheap in adult Pacific walruses (<i>Odobenus rosmarus divergens</i>) Open
Walruses rely on sea-ice to efficiently forage and rest between diving bouts while maintaining proximity to prime foraging habitat. Recent declines in summer sea ice have resulted in walruses hauling out on land where they have to travel f…
View article: Screening the Discrepancy Function of a Computer Model
Screening the Discrepancy Function of a Computer Model Open
Screening traditionally refers to the problem of detecting active inputs in the computer model. In this paper, we develop methodology that applies to screening, but the main focus is on detecting active inputs not in the computer model its…
View article: Replication Data for: Does peer review improve the statistical content of manuscripts? A study on 27,467 manuscripts submitted to four journals
Replication Data for: Does peer review improve the statistical content of manuscripts? A study on 27,467 manuscripts submitted to four journals Open
Replication Data for the manuscript "Does peer review improve the statistical content of manuscripts? A study on 31,794 manuscripts submitted to four journals" Includes the dataset for replicating the study and the generated LIWC style dic…
View article: A Trans-Omics Comparison Reveals Common Gene Expression Strategies in Four Model Organisms and Exposes Similarities and Differences between Them
A Trans-Omics Comparison Reveals Common Gene Expression Strategies in Four Model Organisms and Exposes Similarities and Differences between Them Open
The ultimate goal of gene expression regulation is on the protein level. However, because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amount of a given protein can be attained by …
View article: A trans-omics comparison reveals common gene expression strategies in four model organisms and exposes similarities and differences between them
A trans-omics comparison reveals common gene expression strategies in four model organisms and exposes similarities and differences between them Open
The ultimate goal of gene regulation should focus on the protein level. However, as mRNA is an obligate intermediary, and because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amoun…
View article: Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training
Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training Open
Despite the benefits of multicomponent physical–cognitive training programs (MCCogTPs), lower training intensities in the concurrent approach, and bigger heterogeneity with aging, suggest the need for long-term analyses, with special atten…
View article: Girls4STEM: Gender Diversity in STEM for a Sustainable Future
Girls4STEM: Gender Diversity in STEM for a Sustainable Future Open
Science, Technology, Engineering, and Mathematics (STEM) are key disciplines towards tackling the challenges related to the Sustainable Development Goals. However, evidence shows that women are enrolling in these disciplines in a smaller p…
View article: Towards Breaking the Gender Gap in Science, Technology, Engineering and Mathematics
Towards Breaking the Gender Gap in Science, Technology, Engineering and Mathematics Open
The gender gap in Science, Technology, Engineering and Mathematics (STEM) has drawn the attention of research and academic communities due to its impact in the Digital Society, targeting the fourth and fifth 2030 sustainable development go…
View article: On the drivers of profitability in the banking industry in restructuring times: a Bayesian perspective
On the drivers of profitability in the banking industry in restructuring times: a Bayesian perspective Open
Purpose There is abundant literature analyzing the determinants of banks’ profitability through its main component: the net interest margin. Some of these determinants are suggested by seminal theoretical models and subsequent expansions. …
View article: Incidence and control of black spot syndrome of tiger nut
Incidence and control of black spot syndrome of tiger nut Open
Tiger nut ( Cyperus esculentum ) is a very profitable crop in Valencia, Spain, but in the last years, part of the harvested tubers presents black spots in the skin making them unmarketable. Surveys performed in two consecutive years showed…
View article: What Does Objective Mean in a Dirichlet‐multinomial Process?
What Does Objective Mean in a Dirichlet‐multinomial Process? Open
Summary The Dirichlet‐multinomial process can be seen as the generalisation of the binomial model with beta prior distribution when the number of categories is larger than two. In such a scenario, setting informative prior distributions wh…
View article: Methods and Tools for Bayesian Variable Selection and Model Averaging in Univariate Linear Regression
Methods and Tools for Bayesian Variable Selection and Model Averaging in Univariate Linear Regression Open
In this paper we briefly review the main methodological aspects concerned with the application of the Bayesian approach to model choice and model averaging in the context of variable selection in regression models. This includes prior elic…
View article: BayesVarSel: Bayesian Testing, Variable Selection and model averaging in Linear Models using R
BayesVarSel: Bayesian Testing, Variable Selection and model averaging in Linear Models using R Open
This paper introduces the R package BayesVarSel which implements objective Bayesian methodology for hypothesis testing and variable selection in linear models. The package computes posterior probabilities of the competing hypotheses/models…
View article: Bayesian joint ordinal and survival modeling for breast cancer risk assessment
Bayesian joint ordinal and survival modeling for breast cancer risk assessment Open
We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a proportional‐odds cum…
View article: Exploring Bayesian models to evaluate control procedures for plant disease
Exploring Bayesian models to evaluate control procedures for plant disease Open
Tigernut tubers are the main ingredient in the production of orxata in Valencia, a white soft sweet popular drink. In recent years, the appearance of black spots in the skin of tigernuts has led to important economic losses in orxata produ…
View article: Determinants of between‐hospital variations in outcomes for patients admitted with <scp>COPD</scp> exacerbations: findings from a nationwide clinical audit ( <scp>AUDIPOC</scp> ) in Spain
Determinants of between‐hospital variations in outcomes for patients admitted with <span>COPD</span> exacerbations: findings from a nationwide clinical audit ( <span>AUDIPOC</span> ) in Spain Open
This study demonstrates a noteworthy reduction in the observed crude between-hospital variation in outcomes after accounting for the hospital-cluster effect and the variables representing patient's clinical conditions. This emphasises the …
View article: Variable selection in the analysis of energy consumption-growth nexus
Variable selection in the analysis of energy consumption-growth nexus Open
There is abundant empirical literature that focuses on whether energy consumption is a critical driver of economic growth. The evolution of this literature has largely consisted of attempts to solve the problems and answer the criticisms a…