Anaïs Kervadec
YOU?
Author Swipe
View article: Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome Open
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood, and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet…
View article: Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome Open
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood, and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet…
View article: Tenascin-C from the tissue microenvironment promotes muscle stem cell self-renewal through Annexin A2
Tenascin-C from the tissue microenvironment promotes muscle stem cell self-renewal through Annexin A2 Open
SUMMARY Skeletal muscle tissue self-repair occurs through the finely timed activation of resident muscle stem cells (MuSC). Following perturbation, MuSC exit quiescence, undergo myogenic commitment, and differentiate to regenerate the inju…
View article: The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy
The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy Open
View article: The nutrient sensor CRTC & Sarcalumenin / Thinman represent a new pathway in cardiac hypertrophy
The nutrient sensor CRTC & Sarcalumenin / Thinman represent a new pathway in cardiac hypertrophy Open
Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy. CREB R egulated T ranscription C o-activator ( CRTC ) is a key regulator of metabolism in ma…
View article: First person – Anaïs Kervadec and James Kezos
First person – Anaïs Kervadec and James Kezos Open
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Anaïs Kervadec and James Kezos are co-first aut…
View article: Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm
Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm Open
Atrial fibrillation (AF) is a common and genetically inheritable form of cardiac arrhythmia; however, it is currently not known how these genetic predispositions contribute to the initiation and/or maintenance of AF-associated phenotypes. …
View article: Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells
Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells Open
Defining the mechanisms safeguarding cell fate identity in differentiated cells is crucial to improve 1) - our understanding of how differentiation is maintained in healthy tissues or altered in a disease state, and 2) - our ability to use…
View article: Genetic architecture of natural variation of cardiac performance from flies to humans
Genetic architecture of natural variation of cardiac performance from flies to humans Open
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of t…
View article: Author response: Genetic architecture of natural variation of cardiac performance from flies to humans
Author response: Genetic architecture of natural variation of cardiac performance from flies to humans Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Deciphering the geneti…
View article: Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm
Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm Open
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia in humans, present in > 33 million people worldwide. Although AF is often developed secondary to cardiovascular diseases, endocrine disorders, or lifestyle fa…
View article: Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome Open
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood, and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet…
View article: ArchiHeart - Dataset : Software containers, SQlite database and DGRP data
ArchiHeart - Dataset : Software containers, SQlite database and DGRP data Open
Title : Genetic architecture of natural variation of cardiac performance in flies Abstract : Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlyin…
View article: Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells
Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells Open
The comprehensive characterization of mechanisms safeguarding cell fate identity in differentiated cells is crucial for 1) our understanding of how differentiation is maintained in healthy tissues or misregulated in disease states and 2) t…
View article: Genetic architecture of natural variation of cardiac performance: from flies to Humans
Genetic architecture of natural variation of cardiac performance: from flies to Humans Open
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of t…
View article: PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 Open
Cardiomyocytes undergo significant structural and functional changes after birth, and these fundamental processes are essential for the heart to pump blood to the growing body. However, due to the challenges of isolating single postnatal/a…
View article: ArchiHeart - Dataset : Software containers, SQlite database and DGRP data
ArchiHeart - Dataset : Software containers, SQlite database and DGRP data Open
Title : Genetic architecture of natural variation of cardiac performance in flies Abstract : Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlyin…
View article: Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome Open
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based…
View article: Author response: Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome
Author response: Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Congenital heart diseases (CHDs), includin…
View article: Silencing of CCR4-NOT complex subunits affects heart structure and function
Silencing of CCR4-NOT complex subunits affects heart structure and function Open
The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate …
View article: PGC1/PPAR Drive Cardiomyocyte Maturation through Regulation of Yap1 and SF3B2
PGC1/PPAR Drive Cardiomyocyte Maturation through Regulation of Yap1 and SF3B2 Open
Cardiomyocytes undergo significant levels of structural and functional changes after birth—fundamental processes essential for the heart to produce the volume and contractility to pump blood to the growing body. However, due to the challen…
View article: Patient-specific functional genomics and disease modeling suggest a role for LRP2 in hypoplastic left heart syndrome
Patient-specific functional genomics and disease modeling suggest a role for LRP2 in hypoplastic left heart syndrome Open
Congenital heart diseases (CHD), such as hypoplastic left heart syndrome (HLHS), are considered to have complex genetic underpinnings that are poorly understood. Here, an integrated multi-disciplinary approach was applied to identify novel…
View article: Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors
Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors Open
Extracellular vesicles secreted by iPSC-Pg are effective in the treatment of CHF, possibly, in part, through their specific miRNA signature and the associated stimulation of distinct cardioprotective pathways. The processing and regulatory…
View article: Évaluation des vésicules extracellulaires dérivées de cellules cardiaques humaines comme une alternative à la greffe des cellules : applications dans un modèle d'insuffisance cardiaque chronique
Évaluation des vésicules extracellulaires dérivées de cellules cardiaques humaines comme une alternative à la greffe des cellules : applications dans un modèle d'insuffisance cardiaque chronique Open
Heart failure (HF) is a major public health concern. The lack of donor hearts and the resistance of numerous patients to conventional treatments has led scientists to develop new therapies such as cell therapy. The initial goal of cell the…
View article: Evaluation of extracellular vesicles secreted by human induced pluripotent stem cell-derived beating cardiomyocytes as an alternative to cell transplantation : applications to myocardial repair in a model of chronic heart failure
Evaluation of extracellular vesicles secreted by human induced pluripotent stem cell-derived beating cardiomyocytes as an alternative to cell transplantation : applications to myocardial repair in a model of chronic heart failure Open