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View article: Ethyl acetate extract of breadfruit leaves (Artocarvus altilis) improves lipid profile and reduces F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus)
Ethyl acetate extract of breadfruit leaves (Artocarvus altilis) improves lipid profile and reduces F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus) Open
Dyslipidemia is closely related to the process of lipid peroxidation. In the non-enzymatic peroxidation process of arachidonic acid, an esterification process occurs and produces a metabolite in the form of isoprostane. The most common iso…
View article: Papaya Leaf Ethanol Extract Lowers Malondialdehyde Levels, Increases Superoxide Dismutase Levels, and Increases Leydig Cell Count in Male Rats Given High-Intensity Swimming Exercise
Papaya Leaf Ethanol Extract Lowers Malondialdehyde Levels, Increases Superoxide Dismutase Levels, and Increases Leydig Cell Count in Male Rats Given High-Intensity Swimming Exercise Open
Physical activity is any body movement that occurs due to skeletal muscle contractions that require energy expenditure. Overtraining can trigger oxidative stress due to chronic systemic hypoxia, cause an increase in systemic inflammatory r…
View article: Effectiveness of Sclerotherapy to Cure Lower Limb Chronic Venous Insufficiency Grades 1-6: A Systematic Review and Meta-Analysis
Effectiveness of Sclerotherapy to Cure Lower Limb Chronic Venous Insufficiency Grades 1-6: A Systematic Review and Meta-Analysis Open
Chronic venous insufficiency is a medical condition that impacts the venous system in the lower limbs. The primary characteristic of this condition is the continual elevation of pressure within the leg veins due to walking, which leads to …
View article: Profil pasien sifilis dengan koinfeksi HIV di poliklinik Kulit dan Kelamin RSUP Prof. dr. I G. N. G. Ngoerah, Denpasar periode 2018-2021
Profil pasien sifilis dengan koinfeksi HIV di poliklinik Kulit dan Kelamin RSUP Prof. dr. I G. N. G. Ngoerah, Denpasar periode 2018-2021 Open
Background: Syphilis is a sexually transmitted disease caused by bacterium Treponema pallidum (T. pallidum). HIV coinfection in syphilis can affect clinical manifestations and increase the complications. This study aimed to describe the pr…
View article: Effect of Extract of Basil Leaf (Ocimum Basillicum L) on Ovarian Follice and Estrogen Level in Premenopausal Wistar Rats
Effect of Extract of Basil Leaf (Ocimum Basillicum L) on Ovarian Follice and Estrogen Level in Premenopausal Wistar Rats Open
Introduction:The decrease of estrogen in the aging process causes various complaints in women.This causes limitations in physical activity which ultimately reduces the quality of life.The use of phytopharmaca that has phytoestrogen activit…
View article: Administration Of 45% Robusta (Coffea canephora) Green Coffee Bean Ethanol Extract Solution Could Not Increased Hair Growth But Inhibited The Increase Of 5α-Reductase Type 1 Levels In Male Wistar Rats (Rattus norvegicus) Exposed To Topical Testosterone
Administration Of 45% Robusta (Coffea canephora) Green Coffee Bean Ethanol Extract Solution Could Not Increased Hair Growth But Inhibited The Increase Of 5α-Reductase Type 1 Levels In Male Wistar Rats (Rattus norvegicus) Exposed To Topical Testosterone Open
Background: Hair loss can occur due to disturbances in the follicular cycle. The most common type of hair loss is androgenetic alopecia, which occurs as a result of androgen hormone stimulation of the hair follicles, causing a transition f…
View article: Administration Of 30% Robusta Coffee (Coffea canephora) Silverskin Ethyl Acetate Fraction Cream Inhibited The Increase Of MITF Expression And Melanin Amount In The Skin Of Male Adult Guinea Pig (Cavia porcellus) Exposed To Ultraviolet B Ray
Administration Of 30% Robusta Coffee (Coffea canephora) Silverskin Ethyl Acetate Fraction Cream Inhibited The Increase Of MITF Expression And Melanin Amount In The Skin Of Male Adult Guinea Pig (Cavia porcellus) Exposed To Ultraviolet B Ray Open
Background: Melanin is produced through melanogenesis which involves several molecular processes with microphthalmia-associated transcription factor (MITF) as the main regulator of melanin synthesis. Hyperpigmentation is one of aging sign …
View article: Avocado ( Persea americana Mill.) Seed Extract Cream 10% Inhibited The Increase MMP-12 Enzyme Levels And Elastosis In UVA Exposed Hairless Male Wistar Rats Skin
Avocado ( Persea americana Mill.) Seed Extract Cream 10% Inhibited The Increase MMP-12 Enzyme Levels And Elastosis In UVA Exposed Hairless Male Wistar Rats Skin Open
Background: Skin is the main target of environmental influences, especially chronic exposure to the suns UVA rays which will result in wrinkling, decreased skin elasticity, the appearance of loose skin, and a rough clinical appearance. In …
View article: The Effect of Chayote (Sechium Edule) Extract Cream Can Reduce Matrix Metalloproteinase-2 (MMP-2) Levels and Increase Collagen Density in The Wound Healing Process of Male Wistar Rats (Rattus Novergicus) With Diabetes Mellitus
The Effect of Chayote (Sechium Edule) Extract Cream Can Reduce Matrix Metalloproteinase-2 (MMP-2) Levels and Increase Collagen Density in The Wound Healing Process of Male Wistar Rats (Rattus Novergicus) With Diabetes Mellitus Open
Introduction: The main complication in Diabetes Mellitus patients is delayed wound healing resulting in chronic wounds. Chayote is known as a vegetable, which has anti-inflammatory properties. The tannin and saponin compounds in chayote pr…
View article: The Administration of 15% Sensitive Plant (Mimosa pudica) Leaf Extract Cream Inhibited the Increasing of Tyrosinase Enzyme and the Amount of Melanin in Male Guinea Pig (Cavia porcellus) Skin Exposed to Ultraviolet B
The Administration of 15% Sensitive Plant (Mimosa pudica) Leaf Extract Cream Inhibited the Increasing of Tyrosinase Enzyme and the Amount of Melanin in Male Guinea Pig (Cavia porcellus) Skin Exposed to Ultraviolet B Open
Background: The leaf of sensitive plant (Mimosa pudica Linn) has a fairly high content of flavonoids, which work in inhibiting the tyrosinase enzyme. Changes in the formation of this enzyme will cause the melanin pigment to be disrupted, r…
View article: The positive correlation between serum malondialdehyde levels with vitiligo severity and activity
The positive correlation between serum malondialdehyde levels with vitiligo severity and activity Open
Background: There are several theories that suggest melanocyte death in vitiligo, one example is oxidative stress theory. Oxidative stress primarily manifested by lipid peroxidation ultimately produce malondialdehyde. Malondialdehyde is a …
View article: High plasma H2O2 level and low plasma catalase level as risk factors for acne vulgaris
High plasma H2O2 level and low plasma catalase level as risk factors for acne vulgaris Open
Background: In this recent time, ROS and oxidative stress have been said to play an important role in the pathogenesis of inflamed acne lesions. One example of ROS produced by neutrophil through phagocytosis is H2O2. Nevertheless, there is…
View article: Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation
Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation Open
The presence of ROS is associated with aging, which is damage caused by free radical reactions. ROS causes oxidation of low density lipoprotein (LDL), which builds up in plaque and contributes to inflammation. With aldehyde secondary produ…
View article: Black Soybean (Glycine max (L.) Merr.) 30% Ethanol Extract Cream Inhibited The Increase of Tyrosinase Enzyme Expression and The Amount of Melanin Same Effective as 4% Hydroquinone Cream on Guinea Pig (Cavia porcellus) Skin
Black Soybean (Glycine max (L.) Merr.) 30% Ethanol Extract Cream Inhibited The Increase of Tyrosinase Enzyme Expression and The Amount of Melanin Same Effective as 4% Hydroquinone Cream on Guinea Pig (Cavia porcellus) Skin Open
Background: Hyperpigmentation is one of the signs of skin aging which is mostly caused by Ultraviolet B (UVB) rays exposure. The gold standard for hyperpigmentation therapy is hydroquinone (HQ) but its long-term use can cause side effects …
View article: Clitoria ternatea L. extract cream 5% inhibits the increase of MMP-1 levels and decrease of collagen amount in Wistar rats (Rattus norvegicus) dermic skin exposed to ultraviolet B
Clitoria ternatea L. extract cream 5% inhibits the increase of MMP-1 levels and decrease of collagen amount in Wistar rats (Rattus norvegicus) dermic skin exposed to ultraviolet B Open
Background Photoaging increases MMP-1 (Matrix Metalloprotein-1) and damage collagen by forming Reactive Oxygen Species (ROS). The antioxidant compounds in Clitoria ternatea L . have been studied to lower ROS, thus inhibiting the emergence …
View article: Bidara leaf extract (Ziziphus mauritiana) inhibits Metalloproteinase-1 increase and collagen decrease in female Wistar rat skin exposed to Ultraviolet-B and cigarette smoke
Bidara leaf extract (Ziziphus mauritiana) inhibits Metalloproteinase-1 increase and collagen decrease in female Wistar rat skin exposed to Ultraviolet-B and cigarette smoke Open
Background Exposure to cigarette smoke and ultraviolet-B can activate enzymes that degrade collagen and inhibit its production through increased levels of MMP-1. Bidara leaves with high content of flavonoids and tannins may prevent damage …
View article: Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial Open
Effect of fenugreek seed extract on carbendazim-inhibited spermatogenesis in albino ratsHawazen A. Lamfon
View article: Peran sirkumsisi sebagai pencegahan infeksi herpes genetalis: suatu studi kohort retrospektif
Peran sirkumsisi sebagai pencegahan infeksi herpes genetalis: suatu studi kohort retrospektif Open
Background: Recurrent genital herpes (RGH) is a sexually transmitted infection that is a serious public health problem and is quite prominent in most countries worldwide. Management for this infection is antiviral and circumcision. Male ci…
View article: Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guinea pig (Cavia porcellus) skin
Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guinea pig (Cavia porcellus) skin Open
Background Excessive sun exposure results in increased activity of the tyrosinase enzyme and the amount of melanin in the skin which causes hyperpigmentation, a sign of premature aging. The purpose of this study was to prove that Ashitaba …
View article: Intradermal injection of umbilical cord mesenchymal stem cells was more effective than platelet rich plasma in increasing amount of collagen and fibroblasts in Wistar rats (Rattus norvegicus) back skin exposed to ultraviolet B rays
Intradermal injection of umbilical cord mesenchymal stem cells was more effective than platelet rich plasma in increasing amount of collagen and fibroblasts in Wistar rats (Rattus norvegicus) back skin exposed to ultraviolet B rays Open
Background Ultraviolet B exposure is one of the causes of extrinsic skin aging. Ultraviolet exposure may lead to skin collagen damage. This study about mesenchymal stem cells from umbilical cord (UCMSC) compared with platelet rich plasma (…
View article: Gambaran karakteristik pasien kondiloma akuminata dengan infeksi HIV/AIDS di RSUP Sanglah, Denpasar, Indonesia tahun 2011-2015
Gambaran karakteristik pasien kondiloma akuminata dengan infeksi HIV/AIDS di RSUP Sanglah, Denpasar, Indonesia tahun 2011-2015 Open
Background: Condyloma acuminata, known as genital warts, is a sexually transmitted infection caused by a virus, namely Human Papilloma Virus (HPV). HPV infections are related to other sexually transmitted infections such as the Human Immun…
View article: Lipschutz Ulcer in A Virgin Woman: A Case Report
Lipschutz Ulcer in A Virgin Woman: A Case Report Open
Background: Lipschutz ulcer, also known as vulvae acutum ulcer, is an acute ulcer in the vulva. The aetiology and pathogenesis of Lipschutz ulcer are unclear, but it is known to be associated with infectious diseases such as Mycoplasma inf…
View article: Korelasi jumlah sel CD4 dengan skor nugent pada wanita dengan infeksi human immunodeficiency virus
Korelasi jumlah sel CD4 dengan skor nugent pada wanita dengan infeksi human immunodeficiency virus Open
Introduction: CD4 cell counts are still used to assess disease progression due to infection with Human Immunodeficiency Virus (HIV). The lower the number of CD4 cells, the more susceptible patients are to various kinds of opportunistic inf…
View article: <p>Correlation Between Glutathione Plasma with Degree Severity of Melasma in Balinese Women</p>
Correlation Between Glutathione Plasma with Degree Severity of Melasma in Balinese Women Open
Glutathione plasma has a strong negative correlation with the MASI score in person with melasma.
View article: Condyloma acuminatum in a 62-year-old patient with HIV infection
Condyloma acuminatum in a 62-year-old patient with HIV infection Open
Introduction: Condyloma acuminatum is caused by infection from Human Papilloma Virus (HPV), mostly found in the perineum and genital area. Therefore HPV infection is the most common sexually transmitted infection in the world. Infection of…
View article: High plasma H2O2 level and low plasma catalase level as risk factors for acne vulgaris
High plasma H2O2 level and low plasma catalase level as risk factors for acne vulgaris Open
Background: In this recent time, ROS and oxidative stress have been said to play an important role in the pathogenesis of inflamed acne lesions. One example of ROS produced by neutrophil through phagocytosis is H2O2. Nevertheless, there is…
View article: The positive correlation between serum malondialdehyde levels with vitiligo severity and activity
The positive correlation between serum malondialdehyde levels with vitiligo severity and activity Open
Background: There are several theories that suggest melanocyte death in vitiligo, one example is oxidative stress theory. Oxidative stress primarily manifested by lipid peroxidation ultimately produce malondialdehyde. Malondialdehyde is a …
View article: The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris Open
Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne col…
View article: Korelasi negatif kuat kadar prolaktin plasma yang rendah terhadap derajat keparahan melasma
Korelasi negatif kuat kadar prolaktin plasma yang rendah terhadap derajat keparahan melasma Open
Background: Melasma is a chronic cutaneous hypermelanosis in areas exposed to sunlight. Hormonal factors are known to influence melanogenesis processes such as prolactin as a neuroendocrine modulator in skin epithelial growth and immune sy…
View article: The Topical Skin Application of Purple Corn Extract (Zea Mays) Inhibited the Increase in MMP-1 Levels and Decreased Collagen in Wistar Rats (Rattus Norvegicus) Exposed to UV-B Rays
The Topical Skin Application of Purple Corn Extract (Zea Mays) Inhibited the Increase in MMP-1 Levels and Decreased Collagen in Wistar Rats (Rattus Norvegicus) Exposed to UV-B Rays Open
Formation of free radicals is an important mechanism causing skin aging. Free radicals are highly reactive molecules with unpaired electrons which can directly disrupt various structures of cell membrane, lipids, proteins, and DNA. Antioxi…