Phalguni Anand Alladi
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View article: Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population
Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population Open
Background Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions a…
View article: Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice Open
View article: Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra
Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra Open
View article: Age-associated myelin decompaction and CNPase expression differ in magnitude in the substantia nigra of MPTP-sensitive C57BL/6J mice and MPTP-resistant CD-1 mice
Age-associated myelin decompaction and CNPase expression differ in magnitude in the substantia nigra of MPTP-sensitive C57BL/6J mice and MPTP-resistant CD-1 mice Open
Opposing phenomena of both oligodendrogliosis and oligodendroglial degeneration is reported in the striatum of MPTP-injected mice model of Parkinson’s disease (PD); reducing the clarity on their contribution to PD pathology. Furthermore, t…
View article: Fibrinogen and complement factor H: The two crucial markers of Parkinson’s disease with cognitive impairment
Fibrinogen and complement factor H: The two crucial markers of Parkinson’s disease with cognitive impairment Open
Animal model-assisted validation is vital for biomarker studies. It provides better means for understanding disease pathogenesis and opens avenues for addressing therapeutics. Our earlier non-targeted label free proteomics-based biomarker …
View article: Apoptotic factors and mitochondrial complexes assist determination of strain-specific susceptibility of mice to Parkinsonian neurotoxin MPTP
Apoptotic factors and mitochondrial complexes assist determination of strain-specific susceptibility of mice to Parkinsonian neurotoxin MPTP Open
Identification of genetic mutations in Parkinson’s disease (PD) promulgates the genetic nature of disease susceptibility. Resilience-associated genes being unknown till date, the normal genetic makeup of an individual may be determinative …
View article: Differences in Neuronal Numbers, Morphology and Developmental Apoptosis in Mice Nigra Provide Evidence of Ontogenic Origin of Vulnerability to Parkinson’s Disease
Differences in Neuronal Numbers, Morphology and Developmental Apoptosis in Mice Nigra Provide Evidence of Ontogenic Origin of Vulnerability to Parkinson’s Disease Open
Parkinson’s disease (PD) prevalence varies by ethnicity. In an earlier study we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6J, MPTP-resis…
View article: Aging and MPTP-Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra
Aging and MPTP-Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra Open
BackgroundBoth astroglia and microglia show region-specific distribution pattern in the central nervous system and often maladapt to age-associated alterations within their niche. Studies on autopsied substantia nigra of Parkinson’s diseas…
View article: Aging and MPTP-sensitivity depend on molecular and ultrastructural signatures of astroglia and microglia in mice substantia nigra
Aging and MPTP-sensitivity depend on molecular and ultrastructural signatures of astroglia and microglia in mice substantia nigra Open
Both astroglia and microglia show region-specific distribution in CNS and often maladapt to age-associated alterations within their niche. Studies on autopsied substantia nigra (SN) of Parkinson’s disease (PD) patients and experimental mod…
View article: Differences in neuronal numbers, morphology and developmental apoptosis in mice nigra provide experimental evidence of ontogenic origin of vulnerability to Parkinson’s disease
Differences in neuronal numbers, morphology and developmental apoptosis in mice nigra provide experimental evidence of ontogenic origin of vulnerability to Parkinson’s disease Open
Parkinson disease (PD) prevalence varies by ethnicity. In an earlier study we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6J, MPTP-resista…
View article: Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation
Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation Open
View article: Chitotriosidase, a biomarker of Amyotrophic Lateral Sclerosis accentuates neurodegeneration in spinal motor neurons through neuroinflammation.
Chitotriosidase, a biomarker of Amyotrophic Lateral Sclerosis accentuates neurodegeneration in spinal motor neurons through neuroinflammation. Open
Background: Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models. Search for identification of toxic factor(s) in CSF revealed an en…
View article: Chitotriosidase, a biomarker of Amyotrophic Lateral Sclerosis accentuates neurodegeneration in spinal motor neurons through neuroinflammation.
Chitotriosidase, a biomarker of Amyotrophic Lateral Sclerosis accentuates neurodegeneration in spinal motor neurons through neuroinflammation. Open
Background Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models. Search for identification of toxic factor(s) in CSF revealed an enh…
View article: Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration Open
View article: Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective
Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective Open
Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, are lacking. Here, we report and describe the role of Estrogen Related Receptor α (ERRα, HUGO Gene Nomenclature ESRRA), new mo…
View article: Sporadic amyotrophic lateral sclerosis (SALS) – skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model
Sporadic amyotrophic lateral sclerosis (SALS) – skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model Open
Skeletal muscle atrophy is the most prominent feature of amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease of motor neurons. However, the contribution of skeletal muscle to disease progression remains elusive. O…
View article: The time course analysis of morphological changes induced by Chikungunya virus replication in mammalian and mosquito cells
The time course analysis of morphological changes induced by Chikungunya virus replication in mammalian and mosquito cells Open
Chikungunya virus (CHIKV), a re-emerging Alphavirus, causes chronic myalgia and arthralgia in infected individuals. However, the exact pathophysiology remains undefined till date. Virus induced time course changes in host cells at the ultr…
View article: Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia
Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia Open
Our findings demonstrate that the cerebrospinal fluid from amyotrophic lateral sclerosis patients holds enough cues to induce microglial inflammatory processes as an early event, which may contribute to the neurodegeneration seen in the sp…
View article: Manganese‐ and 1‐methyl‐4‐phenylpyridinium‐induced neurotoxicity display differences in morphological, electrophysiological and genome‐wide alterations: implications for idiopathic Parkinson's disease
Manganese‐ and 1‐methyl‐4‐phenylpyridinium‐induced neurotoxicity display differences in morphological, electrophysiological and genome‐wide alterations: implications for idiopathic Parkinson's disease Open
Idiopathic Parkinson's disease and manganese‐induced atypical parkinsonism are characterized by movement disorder and nigrostriatal pathology. Although clinical features, brain region involved and responsiveness to levodopa distinguish bot…
View article: A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity Open
Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein …
View article: Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients
Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients Open