Anand Anbarasu
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View article: Systems biology-driven identification of biomarkers and significant pathways in radiation-induced hormone-sensitive cancers
Systems biology-driven identification of biomarkers and significant pathways in radiation-induced hormone-sensitive cancers Open
View article: Tagging Fluorescent Reporter to Epinecidin-1 Antimicrobial Peptide
Tagging Fluorescent Reporter to Epinecidin-1 Antimicrobial Peptide Open
In this study, we successfully cloned the fluorescent proteins eGFP and DsRed in-frame with the antimicrobial peptide epinecidin-1 (FIFHIIKGLFHAGKMIHGLV) at the N-terminal. The cloning strategy involved inserting the fluorescent reporters …
View article: In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers
In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers Open
View article: Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia
Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia Open
View article: The evolution of superbugs in space: a genomic perspective on pathogens in the International Space Station environment
The evolution of superbugs in space: a genomic perspective on pathogens in the International Space Station environment Open
View article: Network pharmacology-driven investigation of luteolin from Annona muricata as a promising multi-target inhibitor for pancreatic cancer
Network pharmacology-driven investigation of luteolin from Annona muricata as a promising multi-target inhibitor for pancreatic cancer Open
Pancreatic cancer is a complex and heterogeneous malignancy ranking among the deadliest cancers. The late-stage diagnosis often limits treatment options and reduces survival rates. In recent years, Annona muricata (A. muricata) has emerged…
View article: Genomic landscape of nosocomial Acinetobacter baumannii: A comprehensive analysis of the resistome, virulome, and mobilome
Genomic landscape of nosocomial Acinetobacter baumannii: A comprehensive analysis of the resistome, virulome, and mobilome Open
Acinetobacter baumannii ( A. baumannii ) is a major multidrug-resistant pathogen, posing serious threats in the healthcare settings. This study provides a comprehensive genomic analysis of nosocomial A. baumannii whole-genome sequences ret…
View article: Computational advancements to facilitate therapeutic application of phytochemicals: Where do we stand?
Computational advancements to facilitate therapeutic application of phytochemicals: Where do we stand? Open
The bioactivity of phytochemicals has been widely reported in the literature, however, the abundance of phytochemical resources and their potent activities require laborious screening methods for feasible applications. Owing to the lack of…
View article: Unveiling Berberine analogues as potential inhibitors of Escherichia coli FtsZ through machine learning molecular docking and molecular dynamics approach
Unveiling Berberine analogues as potential inhibitors of Escherichia coli FtsZ through machine learning molecular docking and molecular dynamics approach Open
The bacterial cell division protein FtsZ, a crucial GTPase, plays a vital role in the formation of the contractile Z-ring, which is essential for bacterial cytokinesis. Consequently, inhibiting FtsZ could prevent the formation of proto-fil…
View article: In silico exploration of biosynthetic gene clusters in marine Streptomyces sp. and Nocardiopsis sp. from the western coast of India: Genome-based profiling using whole genome sequencing
In silico exploration of biosynthetic gene clusters in marine Streptomyces sp. and Nocardiopsis sp. from the western coast of India: Genome-based profiling using whole genome sequencing Open
View article: Understanding the vaginal microbiome among women with different genotypes of human papillomavirus infection in remote Andaman islands
Understanding the vaginal microbiome among women with different genotypes of human papillomavirus infection in remote Andaman islands Open
Background Human papillomavirus (HPV) is a viral infection, and its acquisition and persistence are significantly influenced by the vaginal microbiota. Understanding and comparing the vaginal microbiome of HPV infected women in Andaman and…
View article: Biomolecular Interaction of Carnosine and Anti-TB Drug: Preparation of Functional Biopeptide-Based Nanocomposites and Characterization through In Vitro and In Silico Investigations
Biomolecular Interaction of Carnosine and Anti-TB Drug: Preparation of Functional Biopeptide-Based Nanocomposites and Characterization through In Vitro and In Silico Investigations Open
Host-directed therapies (HDTs) resolve excessive inflammation during tuberculosis (TB) disease, which leads to irreversible lung tissue damage. The peptide-based nanostructures possess intrinsic anti-inflammatory and antioxidant properties…
View article: Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types
Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types Open
View article: A Comprehensive Review of Antimicrobial Agents Against Clinically Important Bacterial Pathogens: Prospects for Phytochemicals
A Comprehensive Review of Antimicrobial Agents Against Clinically Important Bacterial Pathogens: Prospects for Phytochemicals Open
Antimicrobial resistance (AMR) hinders the effective treatment of a range of bacterial infections, posing a serious threat to public health globally, as it challenges the currently available antimicrobial drugs. Among the various modes of …
View article: Identifying Novel Therapeutics for the Resistant Mutant “F533L” in PBP3 of <i>Pseudomonas aeruginosa</i> Using ML Techniques
Identifying Novel Therapeutics for the Resistant Mutant “F533L” in PBP3 of <i>Pseudomonas aeruginosa</i> Using ML Techniques Open
Pseudomonas aeruginosa (P. aeruginosa) is a highly infectious and antibiotic-resistant bacterium, which causes acute and chronic nosocomial infections. P. aeruginosa exhibits multidrug resistance due to the emergence of resis…
View article: Anti-bacterial compounds from Indian curry-leaf tree Murraya koenigii have potential to inhibit carbapenem-resistant Streptococcus pneumoniae
Anti-bacterial compounds from Indian curry-leaf tree Murraya koenigii have potential to inhibit carbapenem-resistant Streptococcus pneumoniae Open
Problems considered: Spike in the mortality rates due to pneumococcal infections post-COVID-19 has raised clinical concerns globally. β-lactam antibiotic-susceptibility in the causative organism, Streptococcus pneumoniae has been compromis…
View article: Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant <i>Acinetobacter baumannii</i> clinical isolates
Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant <i>Acinetobacter baumannii</i> clinical isolates Open
Colistin resistance in Acinetobacter baumannii is mediated by multiple mechanisms. Recently, mutations within pmrABC two-component system and overexpression of eptA gene due to upstream insertion of IS Aba1 have been shown to play a major …
View article: MyxoPortal: a database of myxobacterial genomic features
MyxoPortal: a database of myxobacterial genomic features Open
Myxobacteria are predatory bacteria with antimicrobial activity, utilizing complex mechanisms to kill their prey and assimilate their macromolecules. Having large genomes encoding hundreds of secondary metabolites, hydrolytic enzymes and a…
View article: Cefiderocol susceptibility endows hope in treating carbapenem-resistant <i>Pseudomonas aeruginosa</i> : insights from <i>in vitro</i> and <i>in silico</i> evidence
Cefiderocol susceptibility endows hope in treating carbapenem-resistant <i>Pseudomonas aeruginosa</i> : insights from <i>in vitro</i> and <i>in silico</i> evidence Open
Clinical carbapenemase-positive Pseudomonas aeruginosa strains showing pan-β-lactam resistance had stabilizing mutations in penicillin-binding protein-3. Cefiderocol however showed efficacy with low MIC-values due to multi-target specifici…
View article: Structure Elucidation and Interaction Dynamics of MefA-MsrD Efflux Proteins in <i>Streptococcus pneumoniae</i>: Impact on Macrolide Susceptibility
Structure Elucidation and Interaction Dynamics of MefA-MsrD Efflux Proteins in <i>Streptococcus pneumoniae</i>: Impact on Macrolide Susceptibility Open
Macrolides are empirically used to treat bacterial community-acquired pneumonia (CAP). Streptococcus pneumoniae, being the major pathogen responsible for bacterial CAP with high mortality rates, express MefA-MsrD efflux pumps to hin…
View article: NFX1‐123: A potential therapeutic target in cervical cancer
NFX1‐123: A potential therapeutic target in cervical cancer Open
NFX1‐123 is a splice variant isoform of the NFX1 gene. It is highly expressed in cervical cancers caused by HPV, and NFX1‐123 is a protein partner with the HPV oncoprotein E6. Together, NFX1‐123 and E6 affect cellular growth, longevity, an…
View article: Back Cover Image, Volume 95, Number 6, June 2023
Back Cover Image, Volume 95, Number 6, June 2023 Open
Back Cover Caption: The cover image is based on the Research Article NFX1-123: A potential therapeutic target in cervical cancer by Sreenivasulu Chintala et al., https://doi.org/10.1002/jmv.28856. Image Credit: Rachel A. Katzenellenbogen.
View article: Impact of the COVID-19 pandemic on routine vaccine landscape: A global perspective
Impact of the COVID-19 pandemic on routine vaccine landscape: A global perspective Open
The coronavirus disease (COVID-19) threat is subsiding through extensive vaccination worldwide. However, the pandemic imposed major disruptions in global immunization programs and has aggravated the risks of vaccine-preventable disease (VP…
View article: Multi-Epitope Vaccine for Monkeypox Using Pan-Genome and Reverse Vaccinology Approaches
Multi-Epitope Vaccine for Monkeypox Using Pan-Genome and Reverse Vaccinology Approaches Open
Outbreaks of monkeypox virus infections have imposed major health concerns worldwide, with high morbidity threats to children and immunocompromised adults. Although repurposed drugs and vaccines are being used to curb the disease, the evol…
View article: Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach
Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach Open
View article: Cone-Beam Computed Tomography-Assisted Evaluation of the Bone Regenerative Potential of Modulated Sol–Gel-Synthesized 45S5 Bioglass Intended for Alveolar Bone Regeneration
Cone-Beam Computed Tomography-Assisted Evaluation of the Bone Regenerative Potential of Modulated Sol–Gel-Synthesized 45S5 Bioglass Intended for Alveolar Bone Regeneration Open
Objectives: The objective of the study was to evaluate the in vitro cell compatibility and in vivo regenerative potential of 45S5 Bioglass (45S5-BG)-based bone graft implanted in critical-size defects (CSD) created at rat calvaria using co…
View article: Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets
Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets Open
View article: Epidemiology of Multidrug Resistance among Salmonella enterica serovars typhi and paratyphi A at a Tertiary Pediatric Hospital in India Over a Decade; In-silico Approach to Elucidate the Molecular Mechanism of Quinolone Resistance
Epidemiology of Multidrug Resistance among Salmonella enterica serovars typhi and paratyphi A at a Tertiary Pediatric Hospital in India Over a Decade; In-silico Approach to Elucidate the Molecular Mechanism of Quinolone Resistance Open
Quinolone resistance was high among cases of enteric fever, whereas no resistance was observed among third-generation cephalosporins. In-silico studies indicated that a mutation in gyrase A might be the cause of the gradual increase in cip…
View article: Emergence of Meropenem Resistance Among Cefotaxime Non-susceptible Streptococcus pneumoniae: Evidence and Challenges
Emergence of Meropenem Resistance Among Cefotaxime Non-susceptible Streptococcus pneumoniae: Evidence and Challenges Open
The principal causative agent of acute bacterial meningitis (ABM) in children and the elderly is Streptococcus pneumoniae , with a widespread increase in penicillin resistance. Resistance is due to non-synonymous single-nucleotide polymorp…
View article: Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease
Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease Open