Anand D. Jeyasekharan
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View article: Supplementary appendix from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma
Supplementary appendix from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma Open
Supplementary methods. Supplementary Figure 1. Phenotyping of B-cells in non-malignant tissues. A, Quantitation of marker positivity across ten tonsil and two reactive lymph node samples (rLN). Analysis is spatially resolved between the GC…
View article: Supplementary tables from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma
Supplementary tables from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma Open
Supplementary table 1. Per-patient mfIHC MYC, BCL2 and BCL6 single oncogene and subpopulation scores for normal tonsil tissue and reactive lymph node tissue. Supplementary table 2. Per-patient mfIHC MYC, BCL2 and BCL6 single oncogene and s…
View article: Supplementary Figures S1-12 from Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma
Supplementary Figures S1-12 from Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma Open
Supplementary Figure S1. Tumor-infiltrating CD8+ cell was positive correlation to efficacy of the combined DNMT inhibition and anti-PD-1 mAb therapy. Supplementary Figure S2. No significant reduction in body weight of EL4 tumor-bearing mic…
View article: A single-cell co-expression score of MYC and BCL2 identifies high-risk BCR-addicted DLBCL benefiting from polatuzumab vedotin in the POLARIX trial
A single-cell co-expression score of MYC and BCL2 identifies high-risk BCR-addicted DLBCL benefiting from polatuzumab vedotin in the POLARIX trial Open
Introduction: Double Expressor Lymphoma (DEL) refers to diffuse large B-cell lymphoma (DLBCL) with overexpression of the oncogenes MYC and BCL2 and carries a poor prognosis. However, the clinical utility of DEL is limited by variability in…
View article: 1101 Spillover-aware phenotyping (SAP) enables robust and high-throughput cell phenotyping on CNS lymphoma TMAs
1101 Spillover-aware phenotyping (SAP) enables robust and high-throughput cell phenotyping on CNS lymphoma TMAs Open
View article: Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma
Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma Open
Anti–PD-1 immunotherapy has demonstrated significant antitumor efficacy in relapsed or refractory NK/T-cell lymphoma (R/R NKTL), but resistance remains a substantial challenge. In this study, we evaluate DNA methyltransferase (DNMT) inhibi…
View article: Peripheral T-Cell Lymphoma Management in East and Southeast Asia: Real-World Challenges and Aspirations of the Asian Lymphoma Study Group
Peripheral T-Cell Lymphoma Management in East and Southeast Asia: Real-World Challenges and Aspirations of the Asian Lymphoma Study Group Open
PURPOSE Peripheral T-cell lymphomas (PTCLs) encompass a group of rare and diverse disease entities for which contemporary frontline treatment options are limited. Patient outcomes for PTCL remain poor globally, and disparities in health ca…
View article: Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma Open
Identifying tumor suppressor genes is predicted to inform on the development of novel strategies for cancer therapy. To identify new lymphoma driving processes that cooperate with oncogenic MYC, which is abnormally highly expressed in ~70%…
View article: Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone
Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone Open
The germinal center (GC) dark zone (DZ) and light zone represent distinct anatomical regions in lymphoid tissue where B cell proliferation, immunoglobulin diversification, and selection are coordinated. Diffuse large B cell lymphomas (DLBC…
View article: Proliferative CD8 T-cells : A Novel Immune Microenvironmental Determinant of Outcomes in Multiple Myeloma
Proliferative CD8 T-cells : A Novel Immune Microenvironmental Determinant of Outcomes in Multiple Myeloma Open
Multiple myeloma (MM) remains incurable despite major therapeutic advances, and the tumor microenvironment (TME) plays an important role in disease progression. Since T-cell dysfunction is of particular importance in MM, we hypothesised th…
View article: PatternExtract: A facile, scalable pipeline for point pattern generation from spatial imaging data
PatternExtract: A facile, scalable pipeline for point pattern generation from spatial imaging data Open
We present PatternExtract, an open-source pipeline that generates accurate spatial point patterns from RGB pathology images and cell coordinate data without relying on composite channels or proprietary software. Using a novel two-kernel ti…
View article: A single-cell atlas of ribosomal protein heterogeneity across human tissues reveals phenotypes of biological and clinical significance
A single-cell atlas of ribosomal protein heterogeneity across human tissues reveals phenotypes of biological and clinical significance Open
Ribosomes, once considered homogenous, exhibit dynamic compositional heterogeneity driven by differential ribosomal protein (RP) gene expression, modulating translational control. The exact cellular contributions to ribosomal heterogeneity…
View article: 431 | EZH2 GAIN‐OF‐FUNCTION MUTATIONS CONFER EVEROLIMUS SENSITIVITY IN DIFFUSE LARGE B CELL LYMPHOMA
431 | EZH2 GAIN‐OF‐FUNCTION MUTATIONS CONFER EVEROLIMUS SENSITIVITY IN DIFFUSE LARGE B CELL LYMPHOMA Open
View article: 168 | C5ORF30/MACIR IS A ROBUST PROGNOSTIC MARKER IN DLBCL, AND MODULATES THE TUMOR MICROENVIRONMENT THROUGH HLA EXPRESSION
168 | C5ORF30/MACIR IS A ROBUST PROGNOSTIC MARKER IN DLBCL, AND MODULATES THE TUMOR MICROENVIRONMENT THROUGH HLA EXPRESSION Open
View article: 651 | UTILITY OF GERIATRIC ASSESSMENT TOOLS TO PREDICT CHEMOTOXICITY AMONGST ELDERLY PATIENTS WITH DLBCL
651 | UTILITY OF GERIATRIC ASSESSMENT TOOLS TO PREDICT CHEMOTOXICITY AMONGST ELDERLY PATIENTS WITH DLBCL Open
View article: 206 | SPATIAL AND SINGLE‐CELL MULTI‐OMICS REVEAL MACROPHAGE HETEROGENEITY BETWEEN PRIMARY CNS LYMPHOMA AND DIFFUSE LARGE B‐CELL LYMPHOMA
206 | SPATIAL AND SINGLE‐CELL MULTI‐OMICS REVEAL MACROPHAGE HETEROGENEITY BETWEEN PRIMARY CNS LYMPHOMA AND DIFFUSE LARGE B‐CELL LYMPHOMA Open
View article: 204 | AN EXPLAINABLE ARTIFICIAL INTELLIGENCE mDELRelapseNet MODEL TO PREDICT RELAPSE IN DIFFUSE LARGE B‐CELL LYMPHOMA BASED ON THE SPATIAL ORGANIZATION OF MYC+BCL2+BCL6− Cells
204 | AN EXPLAINABLE ARTIFICIAL INTELLIGENCE mDELRelapseNet MODEL TO PREDICT RELAPSE IN DIFFUSE LARGE B‐CELL LYMPHOMA BASED ON THE SPATIAL ORGANIZATION OF MYC+BCL2+BCL6− Cells Open
View article: 172 | AGGRESSIVE B‐CELL LYMPHOMAS RETAIN ATR‐DEPENDENT DETERMINANTS OF T‐CELL EXCLUSION FROM THE GERMINAL CENTER DARK ZONE
172 | AGGRESSIVE B‐CELL LYMPHOMAS RETAIN ATR‐DEPENDENT DETERMINANTS OF T‐CELL EXCLUSION FROM THE GERMINAL CENTER DARK ZONE Open
View article: MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance Open
Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementatio…
View article: Single-cell Resolved Oncogene Co-expression: From Principles to Clinical Impact
Single-cell Resolved Oncogene Co-expression: From Principles to Clinical Impact Open
Summary: This commentary explores the concept and utility of studying oncogene co-expression at single-cell resolution and its clinical and biological implications. We emphasize the importance of scalable methods, mathematically driven qua…
View article: Single-cell Pharmacogenomic Landscapes of Epigenetic Drug Resistance Revealed by Gastric Cancer Perturb-seq
Single-cell Pharmacogenomic Landscapes of Epigenetic Drug Resistance Revealed by Gastric Cancer Perturb-seq Open
Gene expression signatures ("molecular phenotypes") are extensively utilized in cancer research. To study how gastric cancer (GC) molecular phenotypes are shaped by cell-intrinsic genetic alterations interacting with cell-extrinsic therape…
View article: A Chk1-Sp1-CD59 axis of the DNA damage response impedes rituximab-mediated complement-dependent cytotoxicity
A Chk1-Sp1-CD59 axis of the DNA damage response impedes rituximab-mediated complement-dependent cytotoxicity Open
DNA damage responses primarily coordinate intracellular processes, but their effects on the cell surface remain poorly understood. We uncovered a DNA damage response at the cell surface that regulates complement dependent cytotoxicity (CDC…
View article: Improving access to chimeric antigen receptor T-cells for refractory or relapsing diffuse large B cell lymphoma therapy in Asia
Improving access to chimeric antigen receptor T-cells for refractory or relapsing diffuse large B cell lymphoma therapy in Asia Open
View article: A multi-task domain-adapted model to predict chemotherapy response from mutations in recurrently altered cancer genes
A multi-task domain-adapted model to predict chemotherapy response from mutations in recurrently altered cancer genes Open
Next-generation sequencing (NGS) is increasingly utilized in oncological practice; however, only a minority of patients benefit from targeted therapy. Developing drug response prediction (DRP) models is important for the "untargetable" maj…
View article: 804 A novel high content, high throughput platform for immunotherapy-based combinatorial drug screening identifies regulators of antibody-dependent cellular cytotoxicity
804 A novel high content, high throughput platform for immunotherapy-based combinatorial drug screening identifies regulators of antibody-dependent cellular cytotoxicity Open
View article: 1395 Divergent tumor immune microenvironments in endemic and sporadic Burkitt lymphoma
1395 Divergent tumor immune microenvironments in endemic and sporadic Burkitt lymphoma Open
View article: 1387 Clinical relevance of spatially-resolved transcriptional signatures characterizing macrophages from the light and dark zone of the germinal centre
1387 Clinical relevance of spatially-resolved transcriptional signatures characterizing macrophages from the light and dark zone of the germinal centre Open
View article: ColocZStats: a z-stack signal colocalization extension tool for 3D slicer
ColocZStats: a z-stack signal colocalization extension tool for 3D slicer Open
Confocal microscopy has evolved to be a widely adopted imaging technique in molecular biology and is frequently utilized to achieve accurate subcellular localization of proteins. Applying colocalization analysis on image z-stacks obtained …
View article: Personalised Drug Identifier for Cancer Treatment with Transformers using Auxiliary Information
Personalised Drug Identifier for Cancer Treatment with Transformers using Auxiliary Information Open
Cancer remains a global challenge due to its growing clinical and economic burden. Its uniquely personal manifestation, which makes treatment difficult, has fuelled the quest for personalized treatment strategies. Thus, genomic profiling i…
View article: ColocZStats: A Z-Stack Signal Colocalization Extension Tool for 3D Slicer
ColocZStats: A Z-Stack Signal Colocalization Extension Tool for 3D Slicer Open
Confocal microscopy has evolved as a widely adopted imaging technique in molecular biology and is frequently utilized to achieve accurate subcellular localization of proteins. Applying colocalization analysis on image z-stacks obtained fro…