Anandi Krishnan
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View article: Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants
Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants Open
The Omicron variants of SARS‐CoV‐2 are characterized by their high transmissibility and immune evasion. Existing treatments using neutralizing antibodies have shown different effectiveness due to variants with mutations occurring mainly in…
View article: A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis Open
Myeloproliferative neoplasms are stem cell–driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukem…
View article: Unfolded Protein Response: From cellular stress to disease pathogenesis, with insights into platelet biology
Unfolded Protein Response: From cellular stress to disease pathogenesis, with insights into platelet biology Open
Maintaining protein homeostasis, or proteostasis, is crucial for human health and disease prevention. The endoplasmic reticulum (ER) plays a central role in protein folding and processing, making it pivotal in this process. Disruptions in …
View article: Heterogeneity of platelets and their responses
Heterogeneity of platelets and their responses Open
There has been increasing recognition of heterogeneity in blood platelets and their responses, particularly in recent years, where next-generation technologies and advanced bioinformatic tools that interrogate "big data" have enabled large…
View article: Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen Consumption
Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen Consumption Open
Background Traumatic injury is a leading cause of death for those under the age of 45, with 40% occurring due to hemorrhage. Severe tissue injury and hypoperfusion lead to marked changes in coagulation, thereby preventing formation of a st…
View article: JA(c)K-in-the-platelet and M(i)PL fetch PF4
JA(c)K-in-the-platelet and M(i)PL fetch PF4 Open
6 months, with reconstitution recovering only after a year.Furthermore, a high level of PD-1 + T cells at baseline was associated with impaired disease control, in direct contrast to the profile observed with I+R.Given these correlative as…
View article: Newly identified roles for <scp>PIEZO1</scp> mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis
Newly identified roles for <span>PIEZO1</span> mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis Open
Mechanisms through which mature megakaryocytes (Mks) and their progenitors sense the bone marrow extracellular matrix to promote lineage differentiation in health and disease are still partially understood. We found PIEZO1, a mechanosensit…
View article: SIRPα controls CD47-dependent platelet clearance in mice and humans
SIRPα controls CD47-dependent platelet clearance in mice and humans Open
Over the last decade, more data has revealed that increased surface expression of the “don’t eat me” CD47 protein on cancer cells plays a role in immune evasion and tumor progression, with CD47 blockade emerging as a new therapy in immuno-…
View article: Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in <i>JAK2 V617F</i> Myeloproliferative Neoplasms
Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in <i>JAK2 V617F</i> Myeloproliferative Neoplasms Open
Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by hyperactive JAK/STAT signaling, thromboses, abnormal bleeding, and increased risk of transformation to myelofibrosis (MF) …
View article: Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms
Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms Open
Patients with chronic Myeloproliferative Neoplasms (MPN) including polycythemia vera (PV) and essential thrombocythemia (ET) exhibit unique clinical features, such as a tendency toward thrombosis and hemorrhage, and risk of disease progres…
View article: A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis
A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis Open
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. The majority of patients present with early-stage disease, but a substantial proportion progress to myelofibrosis and/or s…
View article: Enkurin: a novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens
Enkurin: a novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens Open
Impaired protein homeostasis, though well established in age-related disorders, has been recently linked with the pathogenesis of myeloproliferative neoplasms (MPNs). However, little is known about MPN-specific modulators of proteostasis, …
View article: Increased bleeding and thrombosis in myeloproliferative neoplasms mediated through altered expression of inherited platelet disorder genes
Increased bleeding and thrombosis in myeloproliferative neoplasms mediated through altered expression of inherited platelet disorder genes Open
An altered thrombo-hemorrhagic profile has long been observed in patients with myeloproliferative neoplasms (MPNs). We hypothesized that this observed clinical phenotype may result from altered expression of genes known to harbor genetic v…
View article: Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens
Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens Open
Impaired protein homeostasis, though well established in age-related disorders, has been linked in recent research with the pathogenesis of myeloproliferative neoplasms (MPNs). As yet, however, little is known about MPN-specific modulators…
View article: IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis
IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis Open
Platelets and megakaryocytes are critical players in immune responses. Recent reports suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to induce altered platelet reactivity. We determined whether nonvir…
View article: Whole-genome CRISPR screening identifies <i>N-</i>glycosylation as a genetic and therapeutic vulnerability in <i>CALR</i>-mutant MPNs
Whole-genome CRISPR screening identifies <i>N-</i>glycosylation as a genetic and therapeutic vulnerability in <i>CALR</i>-mutant MPNs Open
Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by which CALR mutations cause MPNs has been elucidated, there currently are no clonally selecti…
View article: Inhaled Gold Nano‐Star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation in a Small Animal Model
Inhaled Gold Nano‐Star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation in a Small Animal Model Open
Pulmonary metastases pose treatment challenges for many cancers, including triple‐negative breast cancer (TNBC). A novel suicide gene and therapeutic microRNAs (miRs) combination therapy against lung metastases in vivo is tested in mouse m…
View article: Evaluation of immune evasion in SARS-CoV-2 Delta and Omicron variants
Evaluation of immune evasion in SARS-CoV-2 Delta and Omicron variants Open
Emerging SARS-CoV-2 variants with higher transmissibility and immune escape remain a persistent threat across the globe. This is evident from the recent outbreaks of the Delta (B.1.617.2) and Omicron variants. These variants have originate…
View article: Platelet Transcriptome Yields Progressive Markers in Chronic Myeloproliferative Neoplasms and Identifies Putative Targets of Therapy
Platelet Transcriptome Yields Progressive Markers in Chronic Myeloproliferative Neoplasms and Identifies Putative Targets of Therapy Open
Predicting disease progression remains a particularly challenging endeavor in chronic degenerative disorders and cancer, thus limiting early detection, risk stratification, and preventive interventions. Here, profiling the spectrum of chro…
View article: Platelet Heterogeneity in Myeloproliferative Neoplasms
Platelet Heterogeneity in Myeloproliferative Neoplasms Open
Myeloproliferative neoplasms (MPNs) are a group of malignant disorders of the bone marrow where a dysregulated balance between proliferation and differentiation gives rise to abnormal numbers of mature blood cells. MPNs encompass a spectru…
View article: Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms
Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms Open
Predicting disease progression remains a particularly challenging endeavor in chronic degenerative disorders and cancer, thus limiting early detection, risk stratification, and preventive interventions. Here, profiling the three chronic su…
View article: Camouflaged Hybrid Cancer Cell‐Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple‐Negative Breast Cancer to Doxorubicin
Camouflaged Hybrid Cancer Cell‐Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple‐Negative Breast Cancer to Doxorubicin Open
Camouflaged cell‐membrane‐based nanoparticles have gained increasing attention owing to their improved biocompatibility and immunomodulatory properties. Using nanoparticles prepared from the membranes of specific cell types or fusions deri…