Ananta Ghimire
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View article: Overall response rates and progression free survival rates of bispecific antibodies vs CAR-T in the treatment of extramedullary disease and high-risk cytogenetics in relapsed multiple myeloma: A systematic review and meta-analysis
Overall response rates and progression free survival rates of bispecific antibodies vs CAR-T in the treatment of extramedullary disease and high-risk cytogenetics in relapsed multiple myeloma: A systematic review and meta-analysis Open
Background: Bispecific antibodies (BsAb) and Chimeric antigen receptor T-cell therapy (CAR-T) have significantly transformed treatment landscape for patients with relapsed, refractory multiple myeloma (RRMM) after four or more prior lines …
View article: Comparative efficacy of doxycycline and its analogues with autologous blood patch pleurodesis for persistent air leak following secondary spontaneous pneumothorax in adults—a systematic review
Comparative efficacy of doxycycline and its analogues with autologous blood patch pleurodesis for persistent air leak following secondary spontaneous pneumothorax in adults—a systematic review Open
Among chemical pleurodesis agents, doxycycline is reported to be having higher success rate and less recurrences. However, it is found to be inferior when compared directly to ABPP.
View article: Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker
Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker Open
Periprosthetic infections are one of the most serious complications in orthopedic surgeries, and those caused by Staphylococcus aureus (S. aureus) are particularly hard to treat due to their tendency to form biofilms on implants and their …
View article: Study of testicular vascularity after totally extraperitoneal repair in inguinal hernia
Study of testicular vascularity after totally extraperitoneal repair in inguinal hernia Open
Background: Totally extra-peritoneal repair is one of the commonly used method for repair of inguinal hernia which is gaining popularity in recent days. Its effect on testicular vascularity has not been well established. The objective of t…
View article: Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings
Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings Open
Despite advanced implant sterilization and aseptic surgical techniques, periprosthetic bacterial infection remains a major challenge for orthopedic and dental implants. Bacterial colonization/biofilm formation around implants and their inv…
View article: Micrococcal-Nuclease-Triggered On-Demand Release of Vancomycin from Intramedullary Implant Coating Eradicates <i>Staphylococcus aureus</i> Infection in Mouse Femoral Canals
Micrococcal-Nuclease-Triggered On-Demand Release of Vancomycin from Intramedullary Implant Coating Eradicates <i>Staphylococcus aureus</i> Infection in Mouse Femoral Canals Open
Preventing orthopedic implant-associated bacterial infections remains a critical challenge. Current practices of physically blending high-dose antibiotics with bone cements is known for cytotoxicity while covalently tethering antibiotics t…