Ananthan Ambikairajah
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View article: A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions
A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions Open
INTRODUCTION Timely diagnosis is crucial for managing neurodegenerative conditions. This study investigated whether time from symptom onset to diagnosis differs by clinical syndrome and sex. METHODS This retrospective, cross‐sectional stud…
View article: Sleep characteristics and brain structure: A systematic review with meta-analysis
Sleep characteristics and brain structure: A systematic review with meta-analysis Open
Sleep characteristics - poor quality, short or long sleep - and sleep disorders are predominantly associated with lower brain volumes, suggesting that inadequate sleep (short, long or poor quality) might contribute to neurodegeneration. Th…
View article: A Protocol for Enhancing Allied Health Care for Older People in Residential Care: The EAHOP Intervention
A Protocol for Enhancing Allied Health Care for Older People in Residential Care: The EAHOP Intervention Open
Background: Complications due to frailty and injury after falls are a significant problem for people living in residential aged care. This can lead to a range of negative outcomes including poor physical, social, and psychological well-bei…
View article: Association between dietary magnesium intake, inflammation, and neurodegeneration
Association between dietary magnesium intake, inflammation, and neurodegeneration Open
Background Consistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and that lower BP is associated with improved cerebral health. However, recent findings indicate that the positive effect of diet…
View article: Investigating the synergistic effects of hormone replacement therapy, <scp>apolipoprotein E</scp> and age on brain health in the <scp>UK</scp> Biobank
Investigating the synergistic effects of hormone replacement therapy, <span>apolipoprotein E</span> and age on brain health in the <span>UK</span> Biobank Open
Global prevalence of Alzheimer's Disease has a strong sex bias, with women representing approximately two‐thirds of the patients. Yet, the role of sex‐specific risk factors during midlife, including hormone replacement therapy (HRT) and th…
View article: Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms
Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms Open
Several modifiable risk factors for neurodegeneration and dementia have been identified, although individuals vary in their vulnerability despite a similar risk of exposure. This difference in vulnerability could be explained at least in p…
View article: Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later
Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later Open
Introduction The menopause transition is associated with several cardiometabolic risk factors. Poor cardiometabolic health is further linked to microvascular brain lesions, which can be detected as white matter hyperintensities (WMHs) usin…
View article: Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later
Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later Open
The menopause transition is associated with several cardiometabolic risk factors. Poor cardiometabolic health is further linked to microvascular brain lesions, which can be detected as white matter hyperintensities (WMHs) using T2-FLAIR ma…
View article: Poorer sleep impairs brain health at midlife
Poorer sleep impairs brain health at midlife Open
Sleep is an emerging risk factor for dementia but its association with brain health remains unclear. This study included UK Biobank (n = 29,545; mean age = 54.65) participants at imaging visit with sleep measures and brain scans, and a sub…
View article: Poorer Sleep Quality Impairs Brain Health at Midlife
Poorer Sleep Quality Impairs Brain Health at Midlife Open
Introduction Sleep is an emerging risk factor for dementia but its association with brain health remains unclear. Methods A total of 29,545 UK Biobank participants with sleep measures and brain scans, and a subset (n=14,206) with cognitive…
View article: A review of menopause nomenclature
A review of menopause nomenclature Open
View article: Longitudinal Changes in Fat Mass and the Hippocampus
Longitudinal Changes in Fat Mass and the Hippocampus Open
Objective This study aimed to investigate cross‐sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes. Methods UK Biobank par…
View article: The impact of improving feelings of relatedness on motivation and engagement for tertiary students
The impact of improving feelings of relatedness on motivation and engagement for tertiary students Open
First-year undergraduates may be particularly prone to experiencing difficulties with facilitating feelings of relatedness, due to the recent shift in educational environments (i.e. from high school to university), which may be unfamiliar.…
View article: E-Examinations and the Student Experience Regarding Appropriateness of Assessment and Course Quality in Science and Medical Science
E-Examinations and the Student Experience Regarding Appropriateness of Assessment and Course Quality in Science and Medical Science Open
The interest in, and use of, computers and software for assessment is reported to be increasingly popular via electronic examinations (e-exams). We deepen our understanding of the design, reception, and effectiveness of e-exams for history…
View article: The impact of improving feelings of relatedness on motivation and engagement for tertiary students
The impact of improving feelings of relatedness on motivation and engagement for tertiary students Open
First-year undergraduates may be particularly prone to experiencing difficulties with facilitating feelings of relatedness, due to the recent shift in educational environments (i.e. from high school to university), which may be unfamiliar.…
View article: First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15
First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15 Open
Macrophage inhibitory cytokine-1 (MIC-1), also known as growth differentiation factor 15 (GDF15), is a stress response cytokine. MIC-1/GDF15 is secreted into the cerebrospinal fluid and increased levels of MIC-1/GDF15 are associated with a…