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View article: Therapeutic Potential of Erythrina Genus: Bioactive Phytoconstituents with Potent Antiviral and Antimicrobial Activities
Therapeutic Potential of Erythrina Genus: Bioactive Phytoconstituents with Potent Antiviral and Antimicrobial Activities Open
Infectious diseases present a significant global health challenge, further exacerbated by the rising prevalence of antimicrobial resistance and the limited availability of effective antiviral and antimicrobial agents. The Erythrina genus h…
View article: Anti-Acne Mushrooms: A Review
Anti-Acne Mushrooms: A Review Open
Acne is a common chronic inflammatory skin disease in which the skin pores are clogged with oil and dead skin cells. Acne is the second most common skin disease after dermatitis. Many factors influence the appearance of acne, such as skin …
View article: Psidium guajava Leaves n-Hexane Fraction Antibacterial Activity and the Inhibition of Gene Expression of gtfB and gtfC in the Combination Streptococcus mutans ATCC 25175 and Veillonella parvula ATCC 10790T
Psidium guajava Leaves n-Hexane Fraction Antibacterial Activity and the Inhibition of Gene Expression of gtfB and gtfC in the Combination Streptococcus mutans ATCC 25175 and Veillonella parvula ATCC 10790T Open
The P. guajava leaves n-hexane fraction exhibited antibacterial activity against S. mutans and V. parvula. It may exhibit antibiofilm formation, as it could reduce the expression of the gtfC in the double species bacteria.
View article: Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots
Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots Open
The limited scientific evidence on the analgesic and anti-inflammatory effects of Polypodium feei roots, despite their traditional use in rheumatism treatment, highlights the need for pharmacological validation. The study investigates the …
View article: Antiplasmodial Activity of Ethanol Extract of Sonneratia alba Leaves
Antiplasmodial Activity of Ethanol Extract of Sonneratia alba Leaves Open
Sonneratia alba (S. alba) is a mangrove plant that represents a promising natural source forpotential antimalarial drug development. This study investigates the antimalarial effects of theethanol extract derived from S. alba leaves in a mo…
View article: Antifungal properties of the extracts and fractions of black ear fungus (Auricularia nigricans)
Antifungal properties of the extracts and fractions of black ear fungus (Auricularia nigricans) Open
Background: Fungal infections are a common problem in tropical areas like Indonesia. Therefore, an alternative antifungal therapy is needed, focusing on black ear fungus (Auricularia nigricans), which contains flavonoids, alkaloids, phenol…
View article: UJI AKTIVITAS ANTELMINTIK INFUSA DAN EKSTRAK ETANOL DAUN PEPAYA JEPANG (Cnidoscolus aconitifolius) TERHADAP CACING GELANG BABI (Ascaris suum) SECARA IN VITRO
UJI AKTIVITAS ANTELMINTIK INFUSA DAN EKSTRAK ETANOL DAUN PEPAYA JEPANG (Cnidoscolus aconitifolius) TERHADAP CACING GELANG BABI (Ascaris suum) SECARA IN VITRO Open
Ascaris suum is a parasitic worm in pigs that is closely related to the worm in humans, A. lumbricoides. A literature search shows that A. suum can infect humans. Ascaris is thought to modulate host immune and inflammatory responses, which…
View article: MICROENCAPSULATION OF SCHLEICHERA OLEOSA L. LEAF EXTRACT IN MAINTAINING THEIR BIOLOGICAL ACTIVITY: ANTIOXIDANT AND HEPATOPROTECTIVE
MICROENCAPSULATION OF SCHLEICHERA OLEOSA L. LEAF EXTRACT IN MAINTAINING THEIR BIOLOGICAL ACTIVITY: ANTIOXIDANT AND HEPATOPROTECTIVE Open
Objective: Schleichera oleosa L. leaf extract has been studied to have antioxidant activity due to the presence of phenolic compounds, especially flavonoids. Flavonoid compounds that have potential as antioxidants are generally unstable an…
View article: Cost-minimization analysis of pneumonia treatment in Indonesia
Cost-minimization analysis of pneumonia treatment in Indonesia Open
Pneumonia is one of the significant causes of death in developing countries, including Indonesia. As the capital of West Java, Bandung is one of the cities with the highest pneumonia cases in this province. The objective of this study was …
View article: POTENTIAL ACTIVITY OF KAEMPFEROL AS ANTI-PARKINSON’S; MOLECULAR DOCKING AND PHARMACOPHORE MODELLING STUDY
POTENTIAL ACTIVITY OF KAEMPFEROL AS ANTI-PARKINSON’S; MOLECULAR DOCKING AND PHARMACOPHORE MODELLING STUDY Open
Objective: This study examined molecular docking and pharmacophore modeling to evaluate the potential antiparkinson activity of Kaempferol on various types and classes of receptors. Methods: The molecular docking was performed on various c…
View article: Safety Assessment of Schleichera oleosa Lour. Leaves Extract: Acute and Subchronic Studies
Safety Assessment of Schleichera oleosa Lour. Leaves Extract: Acute and Subchronic Studies Open
Background and Objective: Schleichera oleosa (Sapindaceae) has been reported to be useful in traditional medicine and it has some potential pharmacological activities, such as anticancer, antioxidant and antimicrobial activities. This stud…
View article: Patients’ Perspectives of Interprofessional Collaboration in Breast Cancer Unit
Patients’ Perspectives of Interprofessional Collaboration in Breast Cancer Unit Open
Interprofessional teamwork provides significant benefits for patients. However, qualitative research on interprofessional collaboration in the breast cancer unit is uncommon. Therefore, a qualitative study was conducted to assess the perce…
View article: Evaluation of Experimental Cerebral Malaria of Curcumin and Kaempferol in Plasmodium berghei ANKA-Infected Mice
Evaluation of Experimental Cerebral Malaria of Curcumin and Kaempferol in Plasmodium berghei ANKA-Infected Mice Open
Background: Cerebral malaria (CM) is one of the most severe complications of Plasmodium falciparum infection and the leading cause of death from malaria in endemic areas. Natural products with antioxidant and anti-inflammatory activities h…
View article: MOLECULAR DOCKING STUDY AND PHARMACOPHORE MODELLING OF URSOLIC ACID AS AN ANTIMALARIAL USING STRUCTURE-BASED DRUG DESIGN METHOD
MOLECULAR DOCKING STUDY AND PHARMACOPHORE MODELLING OF URSOLIC ACID AS AN ANTIMALARIAL USING STRUCTURE-BASED DRUG DESIGN METHOD Open
Objective: To investigate the activity of ursolic acid (UA) as antimalarial on various types and classes of Plasmodium falciparum (Pf) receptors using molecular docking and pharmacophore modeling methods. Methods: The molecular docking was…
View article: The combination of apigenin and ursolic acid reduces the severity of cerebral malaria in Plasmodium berghei ANKA-infected Swiss Webster mice
The combination of apigenin and ursolic acid reduces the severity of cerebral malaria in Plasmodium berghei ANKA-infected Swiss Webster mice Open
Exploration of bioflavonoids targeting dengue virus NS5 RNA-dependent RNA polymerase: In silico molecular docking approachDhanasekaran Sivaraman, Pushparaj Selvadoss Pradeep
View article: The Anticonvulsant Activity of Mucoadhesive Buccal Films of Sodium Valproate in Pentylenetetrazole-Induced Seizure Rat Model
The Anticonvulsant Activity of Mucoadhesive Buccal Films of Sodium Valproate in Pentylenetetrazole-Induced Seizure Rat Model Open
Buccal preparations are currently gaining interest in the study of drug delivery systems. These preparations can adhere to mucosal surfaces, hydrate, and deliver the drug across the buccal membrane. Based on the Biopharmaceutics Drug Dispo…
View article: THE EFFECT OF MORINGA LAM LEAF EXTRACT ON PHAGOCYTOSIS ACTIVITY OF MACROPHAGES, ROS, NO, IFN-γ, AND IL-10 ON PBMC IN ADULT PULMONARY TUBERCULOSIS PATIENTS INDUCED BY ESAT-6 IN-VITRO
THE EFFECT OF MORINGA LAM LEAF EXTRACT ON PHAGOCYTOSIS ACTIVITY OF MACROPHAGES, ROS, NO, IFN-γ, AND IL-10 ON PBMC IN ADULT PULMONARY TUBERCULOSIS PATIENTS INDUCED BY ESAT-6 IN-VITRO Open
Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). MTB can inhibit phagolysosomal fusion, so it’s difficult to eliminate, and the BCG vaccine didn’t contain ESAT-6/CFP-10, which caused ther…
View article: Effect of ESAT-6 on Phagocytosis Activity, ROS, NO, IFN-γ, and IL-10 in Peripheral Blood Mononuclear Cells of Pulmonary Tuberculosis Patients
Effect of ESAT-6 on Phagocytosis Activity, ROS, NO, IFN-γ, and IL-10 in Peripheral Blood Mononuclear Cells of Pulmonary Tuberculosis Patients Open
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) that lives intracellularly. MTB can inhibit lysosomal enzymes and phagolysosomal fusion, which is challenging to eliminate. These are due to ESAT-6/CFP-1…
View article: Cytotoxicity, Apoptosis, Migration Inhibition, and Autophagy-Induced by Crude Ricin from Ricinus communis Seeds in A549 Lung Cancer Cell Lines
Cytotoxicity, Apoptosis, Migration Inhibition, and Autophagy-Induced by Crude Ricin from Ricinus communis Seeds in A549 Lung Cancer Cell Lines Open
BACKGROUND Ricin protein derived from Ricinus communis seeds is known to have a high toxicity to humans and animals. Several studies revealed that ricin, belonging to ribosome inactivating protein-I, has cytotoxic properties against variou…
View article: Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line
Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line Open
This study demonstrated the cytotoxicity of CAPE potential to induce apoptosis of breast cancer MCF-7 cell line single and cytotoxic-cytostatic combination with 5-FU. Therefore, further studies to develop CAPE and its derivatives will be r…
View article: In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Open
Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl al…
View article: Antimalaria Activities of Several Active Compounds from Medicinal Plants
Antimalaria Activities of Several Active Compounds from Medicinal Plants Open
The growth and spread of resistance to all first-line antimalarial drugs used in the treatment of malaria today has caused many problems in eradicating malaria in various countries in the world. Researchers have begun to look for candidate…
View article: Preparation of organic-solvent free liposome of Piper albi Linn extract in solution and powder form
Preparation of organic-solvent free liposome of Piper albi Linn extract in solution and powder form Open
Piperine is bioactive alkaloid extracted from white pepper (Piper albi Linn) with several beneficial pharmacological activities. It is also known to enhance the bioavailability of several limited solubilities of other compounds such as cur…
View article: ANALYSIS OF CRUDE RICIN FROM Ricinus communis ORIGINATED FROM NGANJUK, EAST JAVA, INDONESIA, USING LIQUID CHROMATOGRAPHY, COLUMN LIQUID CHROMATOGRAPHY, AND FAST PROTEIN LIQUID CHROMATOGRAPHY (FPLC)
ANALYSIS OF CRUDE RICIN FROM Ricinus communis ORIGINATED FROM NGANJUK, EAST JAVA, INDONESIA, USING LIQUID CHROMATOGRAPHY, COLUMN LIQUID CHROMATOGRAPHY, AND FAST PROTEIN LIQUID CHROMATOGRAPHY (FPLC) Open
Ricinus communis L. (Euphorbiaceae), the local name jarak kepyar, is a tropical plant that is widely planted in East Java, Indonesia. The leaves and seeds of this plant have been traditionally utilized to cure liver disease, stomach disord…
View article: Cytotoxic and Antimigration Activity of Etlingera alba (A.D.) Poulsen Rhizome
Cytotoxic and Antimigration Activity of Etlingera alba (A.D.) Poulsen Rhizome Open
Etlingera alba is one of the Etlingera plants that might have anticancer activity. This study aims to investigate the cytotoxic and antimetastatic activity of E. alba rhizome fractions and migration cell assay against MDA-MB-231 cell lines…
View article: IN VITRO DRUG RELEASE STUDY OF CHLORAMPHENICOL IN SITU GEL WITH BASES MIXTURE OF POLOXAMER 407 AND HPMC BY OPTIMIZATION WITH FACTORIAL DESIGN
IN VITRO DRUG RELEASE STUDY OF CHLORAMPHENICOL IN SITU GEL WITH BASES MIXTURE OF POLOXAMER 407 AND HPMC BY OPTIMIZATION WITH FACTORIAL DESIGN Open
Objective: The objective of this study was to find the best base mixture composition (poloxamer 407 and HPMC) of chloramphenicol in situ gel formula based on in vitro property (Cumulative amount of drug release).
Methods: The in vitro dif…
View article: Determination and Purification of Ricin Protein from Ricinus communis L. Seeds using CLC (Column Liquid Chramotagoraphy) and FPLC (Fast Protein Liquid Chramatography)
Determination and Purification of Ricin Protein from Ricinus communis L. Seeds using CLC (Column Liquid Chramotagoraphy) and FPLC (Fast Protein Liquid Chramatography) Open
Proteins found in all biological systems, from prokaryotes to eukaryotes. Ricin, one of the most toxic substances known isolated from Ricinus communis L. seeds, is a heterodimeric two-domain polypeptide protein that includes chain A (30 kD…
View article: A COMPREHENSIVE CHEMICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL
A COMPREHENSIVE CHEMICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL Open
In situ ophthalmic gel is a gel preparation that is initially in the form of ophthalmic solution that dripped into the eye and then the solution turns into a gel after contact with the surface of the eye. In situ gel will undergo phase cha…
View article: Kaempferol-3-<i>O</i>-Rhamnoside Inhibits the Proliferation of Jurkat CellsThrough Jun Amino-Terminal Kinase Signaling
Kaempferol-3-<i>O</i>-Rhamnoside Inhibits the Proliferation of Jurkat CellsThrough Jun Amino-Terminal Kinase Signaling Open
Background: Indonesian herbal medicine has become target of new drugs against diseases, including cancer. The high incidence and mortality rate of cancer, anticancer resistance, and side effects of chemotherapy contribute to the urgency of…