Anastasia Tsakmaki
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View article: Progesterone sulfates are enterohepatically recycled and stimulate G protein-coupled bile acid receptor 1-mediated gut hormone release
Progesterone sulfates are enterohepatically recycled and stimulate G protein-coupled bile acid receptor 1-mediated gut hormone release Open
Sulfated progesterone species (PMxSs) increase postprandially in women with intrahepatic cholestasis of pregnancy (ICP) but not in women with uncomplicated pregnancy. PMxS can be enterohepatically recycled via active transport from the gut…
View article: Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy Open
View article: Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease
Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Open
View article: Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism
Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism Open
Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with one or mo…
View article: Cytokine Responsive Networks in Human Colonic Epithelial Organoids Unveil a Novel Molecular Stratification of Inflammatory Bowel Disease
Cytokine Responsive Networks in Human Colonic Epithelial Organoids Unveil a Novel Molecular Stratification of Inflammatory Bowel Disease Open
View article: P133 An atlas of canonical cytokine regulated transcriptional networks unveils a novel molecular stratification of IBD
P133 An atlas of canonical cytokine regulated transcriptional networks unveils a novel molecular stratification of IBD Open
Introduction The immune- epithelial interactions are central in our current understanding of inflammatory bowel disease (IBD) pathogenesis. Cytokines have been shown to play an integral part in this cross-talk, with some considered pro-inf…
View article: Diabetes through a 3D lens: organoid models
Diabetes through a 3D lens: organoid models Open
Diabetes is one of the most challenging health concerns facing society. Available drugs treat the symptoms but there is no cure. This presents an urgent need to better understand human diabetes in order to develop improved treatments or ta…
View article: Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy Open
View article: ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids
ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids Open
View article: P059 Cytokine responsive transcriptional networks in inflammatory bowel disease
P059 Cytokine responsive transcriptional networks in inflammatory bowel disease Open
Background Interactions between the immune system and the intestinal epithelium play an important role in the pathogenesis of chronic immune mediated inflammatory diseases, including inflammatory bowel disease (IBD). In IBD, debilitating s…
View article: Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells Open
Objective The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic c…
View article: Peptide-based GIP receptor inhibition exhibits modest metabolic changes in mice when administered either alone or combined with GLP-1 agonism
Peptide-based GIP receptor inhibition exhibits modest metabolic changes in mice when administered either alone or combined with GLP-1 agonism Open
Objective Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with…
View article: ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human
ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human Open
Enteroendocrine cells (EECs) survey the gut luminal environment and co-ordinate hormonal, immune and neuronal responses to it. They exhibit well characterised physiological roles ranging from the control of local gut function to whole body…
View article: Histologic assessment of the intestinal wall following duodenal mucosal resurfacing (DMR): a new procedure for the treatment of insulin-resistant metabolic disease
Histologic assessment of the intestinal wall following duodenal mucosal resurfacing (DMR): a new procedure for the treatment of insulin-resistant metabolic disease Open
Background and study aims Minimally invasive procedures that replicate aspects of bariatric surgery with more favorable safety and tolerability offer an attractive alternative in management of metabolic disease. Duodenal mucosal resurfacin…
View article: DOP60 The interleukin 22 transcriptional programme is activated in human colonic inflammation and associated to anti-TNFα primary non-response in Crohn’s
DOP60 The interleukin 22 transcriptional programme is activated in human colonic inflammation and associated to anti-TNFα primary non-response in Crohn’s Open
Interleukin 22 (IL-22) is an effector cytokine regulated by IL-23, a key player in IBD pathogenesis and target of novel biologics. Preclinical studies suggest a protective role for IL-22 in the context of acute intestinal injury and an inf…
View article: Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection
Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection Open
Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical ga…
View article: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Open
The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from…
View article: Author response: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
Author response: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Open
View article: Cover Image, Volume 20, Issue 3
Cover Image, Volume 20, Issue 3 Open
The cover image, by Zara J. Franklin et al., is based on the Original Article Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass , DOI: 10.1111/dom.13119 . image
View article: 3D intestinal organoids in metabolic research: virtual reality in a dish
3D intestinal organoids in metabolic research: virtual reality in a dish Open
The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review…
View article: Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass
Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass Open
Aims Two unmet therapeutic strategies for diabetes treatment are prevention of beta‐cell death and stimulation of beta‐cell replication. Our aim was to characterize the role of neuropeptide Y receptors in the control of beta‐cell mass. Mat…
View article: Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety Open
Our results demonstrate that FFAR2 is predominantly involved in regulating the effects of fermentable carbohydrate on metabolism and does so, in part, by enhancing PYY cell density and release. This highlights the potential for targeting e…