Anastasios D. Giannou
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View article: Maternal <i>IGHG</i> locus duplications impair infants’ passive immunity
Maternal <i>IGHG</i> locus duplications impair infants’ passive immunity Open
Infants depend on passive immunity to safeguard them against infections during the first months of life. Maternal immunoglobulin G (IgG) antibodies are actively transported across the placenta and confer this protection. In this study, we …
View article: Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice
Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice Open
These findings reveal the crucial functions of IL-6 trans-signaling in preventing mature-onset body fat accumulation induced by certain intestinal microbiota.
View article: Comparison of the Learning Pace of Medical Students and Surgical Residents in a Virtual Reality Laparoscopic Simulation
Comparison of the Learning Pace of Medical Students and Surgical Residents in a Virtual Reality Laparoscopic Simulation Open
Surgical training has evolved from the traditional Halstedian concept to include simulation, such as box trainers or virtual reality (VR), until a certain level of proficiency is achieved. This study aimed to compare the learning pace of m…
View article: Clinical characteristics and outcome of very old (≥90 years) critically ill patients with need for intensive care after surgical intervention
Clinical characteristics and outcome of very old (≥90 years) critically ill patients with need for intensive care after surgical intervention Open
Background Due to increasing life expectancy and decreasing morbidity, society is aging. Especially the group of very old patients (≥90 years) is currently increasing significantly. This leads to increasing numbers of very old patients req…
View article: Overexpression of Tn antigen induces chronic pancreatitis in mice
Overexpression of Tn antigen induces chronic pancreatitis in mice Open
Altered O -glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N -acet…
View article: Cognitive learning versus practical “hands-on” training for acquisition of laparoscopic surgical skills: an optimal combination study
Cognitive learning versus practical “hands-on” training for acquisition of laparoscopic surgical skills: an optimal combination study Open
Background Most minimally invasive surgery (MIS) training curricula involve practical training (PT) and cognitive learning (CL) to different extents. It has been proven that acquiring and training specific skills through CL can improve MIS…
View article: Sexual and reproductive health in overweight and obesity: Aims and visions for integrated research approaches
Sexual and reproductive health in overweight and obesity: Aims and visions for integrated research approaches Open
Overweight and obesity increasingly affect women in their reproductive phase, during family planning, pregnancy, breastfeeding and the postpartum period. Overweight and obesity are associated with impaired sexual and reproductive health, i…
View article: Surgical training simulation modalities in minimally invasive surgery: How to achieve evidence-based curricula by translational research
Surgical training simulation modalities in minimally invasive surgery: How to achieve evidence-based curricula by translational research Open
Surgeons are the main creators for minimally invasive surgery training curricula and often follow a hands-on oriented approach that leaves out equally important aspects of assessment, evaluation, and feedback. Further high-quality research…
View article: Effects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells
Effects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells Open
Studying mesothelial PC in pleural physiology and pathophysiology is at an early stage. Previously, we have highlighted the role of the PC in mesothelial cell phenotypes as well as the role of BBSome components in the context of benign and…
View article: Individualized surgical approach based on Bismuth-Corlette classification for perihilar cholangiocarcinoma
Individualized surgical approach based on Bismuth-Corlette classification for perihilar cholangiocarcinoma Open
Perihilar cholangiocarcinoma, a formidable adversary in the field of hepatobiliary surgery, presents multifaceted challenges. This paper reviews its historical context, classification criteria, and regional variations in definition. It emp…
View article: Colorectal adenocarcinoma of the interposed colon after esophagectomy in infancy: a case report
Colorectal adenocarcinoma of the interposed colon after esophagectomy in infancy: a case report Open
Colorectal carcinomas are a rare but possible complication in an interposed colonic segment used for reconstruction after esophagectomy. We report the case of a patient who underwent colonic interposition surgery in childhood due to esopha…
View article: Virtual reality simulation training in laparoscopic suturing and knot-tying: a narrative review
Virtual reality simulation training in laparoscopic suturing and knot-tying: a narrative review Open
Ellada Akritidou, Panagis M. Lykoudis, Constantinos Nastos, Dionysios Dellaportas, Nikolaos Pararas, Dimitrios Papaconstantinou, Eirini Theofilogiannakou, Efstathia Davoutis, Anastasios D. Giannou, Emmanouil Pikoulis
View article: Transplant of the Abdominal Rectus Fascia in rats, first report of a novel experimental technique
Transplant of the Abdominal Rectus Fascia in rats, first report of a novel experimental technique Open
Background: After intestinal or multivisceral transplant, closing the abdominal wall can be challenging, as negative pressure dressing or synthetic meshes pose risks like infections and fistulas. Clinical practice has evolved from vascular…
View article: IL-22 promotes liver regeneration after portal vein ligation
IL-22 promotes liver regeneration after portal vein ligation Open
IL-22 promotes liver regeneration after PVL. Thus, a combination of IL-22 supplementation and Steap4 blockade could potentially be applied as a novel therapeutic approach to boost liver regeneration without facilitating tumor progression a…
View article: Mouse models of spontaneous liver and lung metastasis for colorectal cancer
Mouse models of spontaneous liver and lung metastasis for colorectal cancer Open
To investigate underlying mechanisms for cancer metastasis and promising therapies in animal models, spontaneous metastasis models can be used to recreate metastasis development. Here, we present three mouse models of spontaneous lung and/…
View article: A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma
A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma Open
Differential glycosylation, marked by the presence of truncated O-glycans, is a distinctive feature of epithelial-derived cancers. However, there is a notable gap in research regarding the expression of Tn and STn antigens in esophageal ad…