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View article: 31Lymphocyte heat shock signature predicts response to immune checkpoint blockade in renal cell carcinoma
31Lymphocyte heat shock signature predicts response to immune checkpoint blockade in renal cell carcinoma Open
Background Immune checkpoint blockade (ICB) therapies have revolutionized treatment for renal cell carcinoma (RCC). Despite this, only a subset of patients respond, and there remains an incomplete understanding of the cellular states that …
View article: 41Single-cell dissection of immunosuppressive myeloid subclusters driving resistance to immune checkpoint therapy in renal cell carcinoma (RCC)
41Single-cell dissection of immunosuppressive myeloid subclusters driving resistance to immune checkpoint therapy in renal cell carcinoma (RCC) Open
Background With immune checkpoint inhibitors (ICIs) now widely used as a primary treatment for metastatic RCC, understanding the composition and function of the tumor microenvironment (TME) has become more important. Numerous studies have …
View article: 24TGF-Beta alters CD8+ T cell phenotype and drives resistance to immune checkpoint inhibitors (ICI) in renal cell carcinoma (RCC)
24TGF-Beta alters CD8+ T cell phenotype and drives resistance to immune checkpoint inhibitors (ICI) in renal cell carcinoma (RCC) Open
Background The most successful treatments for advanced RCC have been ICI-based combination therapies. However, the vast majority of patients with advanced RCC ultimately have disease progression despite ICI treatment, thus necessitating fu…
View article: Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts
Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts Open
Gene expression change is a dominant mode of evolution. Mutations, however, can affect gene expression in multiple cell types. Therefore, gene expression evolution in one cell type can lead to similar gene expression changes in another cel…
View article: Experimental and Phylogenetic Evidence for Correlated Gene Expression Evolution between Dermal and Endometrial Fibroblasts: implications for the evolution of cancer malignancy
Experimental and Phylogenetic Evidence for Correlated Gene Expression Evolution between Dermal and Endometrial Fibroblasts: implications for the evolution of cancer malignancy Open
Changes in transcriptional gene expression is a dominant mode of evolution, mostly driven by mutations at cis-regulatory regions. Mutations can affect gene expression in multiple cell types if the same cis-regulatory elements are used by d…
View article: Proteotype coevolution and quantitative diversity across 11 mammalian species
Proteotype coevolution and quantitative diversity across 11 mammalian species Open
Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomes as refere…
View article: Proteotype Co-evolution and Diversity in Mammals
Proteotype Co-evolution and Diversity in Mammals Open
Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomic variabili…
View article: Tracing the cis-regulatory changes underlying the endometrial control of placental invasion
Tracing the cis-regulatory changes underlying the endometrial control of placental invasion Open
Significance Cellular invasion into adjacent tissue is observed in pregnancy, where the fetal placenta invades the mother’s endometrium, and in cancer, where tumor dissemination into stroma is a necessary step before metastasis. The behavi…
View article: Evolution of higher mesenchymal CD44 expression in the human lineage
Evolution of higher mesenchymal CD44 expression in the human lineage Open
CD44 is an extracellular matrix receptor implicated in cancer progression. CD44 increases the invasibility of skin (SF) and endometrial stromal fibroblasts (ESF) by cancer and trophoblast cells. We reasoned that the evolution of CD44 expre…
View article: The Coevolution of Placentation and Cancer
The Coevolution of Placentation and Cancer Open
Analogies between placentation, in particular the behavior of trophoblast cells, and cancer have been noted since the beginning of the twentieth century. To what degree these can be explained as a consequence of the evolution of placentati…
View article: Cis-Regulatory Differences Explaining Evolved Levels of Endometrial Invasibility in Eutherian Mammals
Cis-Regulatory Differences Explaining Evolved Levels of Endometrial Invasibility in Eutherian Mammals Open
Eutherian (placental) mammals exhibit great differences in the degree of placental invasion into the maternal endometrium, with humans being on the most invasive end. Previously, we have shown that these differences in invasiveness is larg…
View article: Human vulnerability to cancer malignancy is enhanced by evolution of higher mesenchymal CD44 expression compared to other mammals
Human vulnerability to cancer malignancy is enhanced by evolution of higher mesenchymal CD44 expression compared to other mammals Open
CD44 is a membrane-bound extracellular matrix (ECM) receptor interacting, among others, with hyaluronic acid (HA) and osteopontin (OPN). Cancer progression and metastasis are greatly influenced by the cancer micro-environment, consisting o…
View article: Graph Spectral Properties of the Sidechain Networks of Protein Structures: Implications to Allostery and Structure Comparison
Graph Spectral Properties of the Sidechain Networks of Protein Structures: Implications to Allostery and Structure Comparison Open