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View article: Maternal Low-Protein Diet Leads to Mitochondrial Dysfunction and Impaired Energy Metabolism in the Skeletal Muscle of Male Rats
Maternal Low-Protein Diet Leads to Mitochondrial Dysfunction and Impaired Energy Metabolism in the Skeletal Muscle of Male Rats Open
A prenatal low-protein (LP) diet disrupts glucose homeostasis in adult offspring. Skeletal muscles are one of the main sites of glucose clearance, and mitochondria residing in the muscle fibers are central to glucose homeostasis. Our previ…
View article: The Low Protein Diet induced Fetal Programming Leads to Mitochondrial Dysfunction and Metabolic Inflexibility in the Skeletal Muscle of Male Rats
The Low Protein Diet induced Fetal Programming Leads to Mitochondrial Dysfunction and Metabolic Inflexibility in the Skeletal Muscle of Male Rats Open
A prenatal low-protein (LP) diet disrupts glucose homeostasis in adult offspring. Skeletal muscles are one of the main sites of glucose clearance, and mitochondria residing in the muscle fibers are central to glucose homeostasis. Our previ…
View article: 411 Effect of aspirin on mechanical properties of mesenteric arteries in a mouse model of preeclampsia
411 Effect of aspirin on mechanical properties of mesenteric arteries in a mouse model of preeclampsia Open
View article: Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model
Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model Open
Introduction: Preeclampsia (PE) is a hypertensive disorder during pregnancy associated with elevated levels of soluble FMS-like tyrosine kinase (sFLT-1) and increased vascular sensitivity to angiotensin II (ATII). Calcitonin gene-related p…
View article: Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats
Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats Open
The liver is one of the major organs involved in the regulation of glucose and lipid homeostasis. The effectiveness of metabolic activity in hepatocytes is determined by the quality and quantity of its mitochondria. Mitochondrial function …
View article: Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice Open
Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2)…
View article: Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies
Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies Open
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy but the underlying mechanism remains obscure. The aims of this study are to examine if omental adipose tissue (OMAT) and subcutaneous AT (SCAT) differ…
View article: Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring
Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring Open
Gestational low-protein (LP) diet leads to glucose intolerance and insulin resistance in adult offspring. We had earlier demonstrated that LP programming affects glucose disposal in females. Mitochondrial health is crucial for normal gluco…
View article: Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy
Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy Open
Rationale Calcitonin gene-related peptide (CGRP) and its family members adrenomedullin (ADM) and adrenomedullin 2 (ADM2; also known as intermedin) support vascular adaptions in rat pregnancy. Objective This study aimed to assess the relaxa…
View article: Soluble fms-like tyrosine kinase-1 and angiotensin2 target calcitonin gene-related peptide family peptides in maternal vascular smooth muscle cells in pregnancy†
Soluble fms-like tyrosine kinase-1 and angiotensin2 target calcitonin gene-related peptide family peptides in maternal vascular smooth muscle cells in pregnancy† Open
Calcitonin gene-related peptide (CALCB), adrenomedullin (ADM), and adrenomedullin2 (ADM2) are hypotensive peptides that belong to CALCB family of peptides. Goal of this study was to identify the effect of fms-like tyrosine kinase (sFLT-1) …
View article: In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†
In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats† Open
Sex steroids regulate insulin sensitivity and glucose metabolism. We had characterized a lean type 2 diabetes (T2D) rat model using gestational low-protein (LP) diet programming. Our objective was to identify if endocrine dysfunction leadi…
View article: Placental growth factor blunts uterine artery responses to angiotensin II
Placental growth factor blunts uterine artery responses to angiotensin II Open
Objective Changes in maternal serum concentration of placental growth factor (Pl GF ) and vascular response to intravascular infusion of Angiotensin II (Ang II ) follow a bell‐shaped curve pattern during gestation. This study evaluates the…
View article: Adipose Tissue Inflammation and Adrenomedullin Overexpression Contribute to Lipid Dysregulation in Diabetic Pregnancies
Adipose Tissue Inflammation and Adrenomedullin Overexpression Contribute to Lipid Dysregulation in Diabetic Pregnancies Open
Increased macrophage infiltration and TNF-α expression in adipose tissue from GDM, but not from OBS, tissues stimulate ADM and its receptor overexpression, leading to enhanced lipolysis and hyperlipidemia. This might contribute to fetal ma…
View article: The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge
The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge Open
View article: 108: Adipose tissue inflammation stimulates adrenomedullin expression and contributes to lipid metabolic dysregulation in diabetic pregnancies
108: Adipose tissue inflammation stimulates adrenomedullin expression and contributes to lipid metabolic dysregulation in diabetic pregnancies Open
View article: Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies
Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies Open
GDM pregnancies are associated with increased AM and its receptor expression in adipose tissues. AM stimulates lipolysis and leptin and resistin expression, and these effects can be reversed by AM antagonist. To our knowledge, manipulation…
View article: 847: Placental Growth Factor (PlGF): the answer to a 43 year-old enigma?
847: Placental Growth Factor (PlGF): the answer to a 43 year-old enigma? Open
View article: Impaired Vasodilatory Responses of Omental Arteries to CGRP Family Peptides in Pregnancies Complicated by Fetal Growth Restriction
Impaired Vasodilatory Responses of Omental Arteries to CGRP Family Peptides in Pregnancies Complicated by Fetal Growth Restriction Open
The current study demonstrates that FGR is associated with an increase in the sensitivity of OA to bradykinin and decreased sensitivity for ADM and ADM2 ligand-receptor system with no change in the response for CGRP compared to the normal …
View article: 128: Study of transplacental transfer of liposomes with encapsulated contrast agent across normal, IUGR and GDM placentas
128: Study of transplacental transfer of liposomes with encapsulated contrast agent across normal, IUGR and GDM placentas Open
View article: Pregnancy Increases Relaxation in Human Omental Arteries to the CGRP Family of Peptides1
Pregnancy Increases Relaxation in Human Omental Arteries to the CGRP Family of Peptides1 Open
Calcitonin gene-related peptide (CALCB) and its family members adrenomedullin (ADM) and intermedin (ADM2) play important roles in maintaining vascular adaptations during pregnancy in animal models. The present study was designed to evaluat…