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View article: Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model (Adv. Healthcare Mater. 11/2023)
Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model (Adv. Healthcare Mater. 11/2023) Open
Silk Fibers Silk has emerged as a versatile biomaterial for regenerative medicine. In article 2203237, Christine Radtke and co-workers use a silk-based nerve conduit filled with spider silk fibers to treat a rat sciatic nerve defect. The s…
View article: Spider Silk in Peripheral Nerve Regeneration: Unravelling the Material’s Biochemical Properties Responsible for its Success
Spider Silk in Peripheral Nerve Regeneration: Unravelling the Material’s Biochemical Properties Responsible for its Success Open
Introduction: Spider silk (SPSI) has attracted avid interest for medical purposes due to its remarkable performance as a filament for nerve guidance conduits in tissue regenerative applications by supporting nerve growth and nerve regenera…
View article: Adipose-derived Stem Cell Transplantation Enhances Peripheral Nerve Regeneration in a Peroneal Nerve Injury Model in the Rat
Adipose-derived Stem Cell Transplantation Enhances Peripheral Nerve Regeneration in a Peroneal Nerve Injury Model in the Rat Open
Introduction: Despite advances in the treatment of peripheral nerve injury, patients still suffer from incomplete motor recovery. In vivo and in vitro studies demonstrated that adipose derived stem cells (AdSCs) promote peripheral nerve re…
View article: A Fibrous and Porous Nature of Hydrogels Promotes Directed Migration of Schwann Cells
A Fibrous and Porous Nature of Hydrogels Promotes Directed Migration of Schwann Cells Open
Introduction: Hydrogel fillings have been successful in enhancing artificial conduits for nerve injuries, but the ideal hydrogel is yet to be found. Its discovery is impeded by an overflow of available products as well as a lack of in vitr…
View article: Crystallinity and Stiffness of Spider Silk Govern the Migration of Schwann Cells
Crystallinity and Stiffness of Spider Silk Govern the Migration of Schwann Cells Open
Introduction: Nerve guidance conduits are a promising alternative to autologous nerve transplantation and conduits filled with fibrous materials have shown great potential in bridging nerve gaps. The application of spider silk as a filamen…
View article: Comparison of Different Extracellular Vesicles Populations Derived from Adipose Tissue Derived Stromal Cells Depending on Conditioning Period
Comparison of Different Extracellular Vesicles Populations Derived from Adipose Tissue Derived Stromal Cells Depending on Conditioning Period Open
Introduction: Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSC) became an important player in regenerative medicine over past years. The most common protocol to isolate EVs from cell culture, includes a period of fe…
View article: Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model
Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model Open
Advanced nerve guidance conduits can provide an off‐the‐shelf alternative to autografts for the rehabilitation of segmental peripheral nerve injuries. In this study, the excellent processing ability of silk fibroin and the outstanding cell…
View article: QS50. Elucidating the Reasons Behind the Success of Spider Silk In Nerve Regeneration
QS50. Elucidating the Reasons Behind the Success of Spider Silk In Nerve Regeneration Open
Purpose: The successful reconstruction of peripheral nerve injuries remains a major clinical challenge. Nerve guidance conduits are a promising alternative to autologous nerve transplantation and conduits filled with fibrous materials have…
View article: QS65. Exploring the Structural, Morphological, and Chemical Properties of Spider Silk Crucial for its Success in Nerve Regeneration
QS65. Exploring the Structural, Morphological, and Chemical Properties of Spider Silk Crucial for its Success in Nerve Regeneration Open
Purpose: Spider silk (SPSI) as one of nature's most fascinating materials has attracted vivid attention due to its remarkable performance in tissue regenerative applications by supporting nerve growth and nerve regeneration. Particularly f…
View article: 67. Silk-silk Conduits Filled with Native Spider Silk Fibers Successfully Promoted Nerve Regeneration in a 10 Mm Sciatic Nerve Defect in Rats
67. Silk-silk Conduits Filled with Native Spider Silk Fibers Successfully Promoted Nerve Regeneration in a 10 Mm Sciatic Nerve Defect in Rats Open
Purpose: The surgical repair of nerve transection injuries remains a challenging task and often results in unsatisfactory functional recovery. If a direct coaptation is not possible, the current gold-standard is the use of an autograft. Ho…
View article: Nuclear Magnetic Resonance Treatment Accelerates the Regeneration of Dorsal Root Ganglion Neurons in vitro
Nuclear Magnetic Resonance Treatment Accelerates the Regeneration of Dorsal Root Ganglion Neurons in vitro Open
Functional recovery from peripheral nerve injuries depends on a multitude of factors. Schwann cells (SCs) are key players in the regenerative process as they develop repair-specific functions to promote axon regrowth. However, chronically …
View article: OP10: Elucidating the Reasons Behind Hydrogel Induced Cell Elongation and Directed Migration in Schwann Cells
OP10: Elucidating the Reasons Behind Hydrogel Induced Cell Elongation and Directed Migration in Schwann Cells Open
INTRODUCTION: Hydrogel fillings have been successful in enhancing artificial conduits, but the ideal hydrogel is yet to be found. Its discovery is impeded by an overflow of available products as well as a lack of in vitro experiments that …
View article: OP7: Silk Fibroin-Based Conduits Filled with Native Spider Silk Fibers Successfully Promoted Nerve Regeneration in a 10 Mm Sciatic Nerve Defect in Rats
OP7: Silk Fibroin-Based Conduits Filled with Native Spider Silk Fibers Successfully Promoted Nerve Regeneration in a 10 Mm Sciatic Nerve Defect in Rats Open
INTRODUCTION: The current gold-standard for nerve transection injuries is the use of an autograft. However, the availability of autologous nerve tissue is limited. Recent studies supported silk as promising material for tissue engineering …
View article: VP5: Plasma Derived Extracellular Vesicles as a Treatment Option in Nerve Regeneration- An In-Vitro Study
VP5: Plasma Derived Extracellular Vesicles as a Treatment Option in Nerve Regeneration- An In-Vitro Study Open
INTRODUCTION: Previous experiments with Extracellular Vesicles (EVs) derived from highly proliferative mesenchymal stromal cells, f.e. adipose tissue derived stromal cells (ADSC), showed in-vitro an increased proliferation, and migration o…
View article: VP4: Elucidating the Reasons Behind the Success of Spider Silk in Nerve Regeneration
VP4: Elucidating the Reasons Behind the Success of Spider Silk in Nerve Regeneration Open
INTRODUCTION: Spider silk has been established as one of nature's most fascinating materials and has attracted vivid attention due to its unique strength, toughness, and elasticity. The application of the dragline silk of spider genus Neph…
View article: Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28/2a Cells
Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28/2a Cells Open
Nuclear magnetic resonance therapy (NMRT) is discussed as a participant in repair processes regarding cartilage and as an influence in pain signaling. To substantiate the application of NMRT, the underlying mechanisms at the cellular level…
View article: Defining the regenerative effects of native spider silk fibers on primary Schwann cells, sensory neurons, and nerve‐associated fibroblasts
Defining the regenerative effects of native spider silk fibers on primary Schwann cells, sensory neurons, and nerve‐associated fibroblasts Open
The search for a suitable material to promote regeneration after long‐distance peripheral nerve defects turned the spotlight on spider silk. Nerve conduits enriched with native spider silk fibers as internal guiding structures previously d…
View article: Correlating the secondary protein structure of natural spider silk with its guiding properties for Schwann cells
Correlating the secondary protein structure of natural spider silk with its guiding properties for Schwann cells Open
The successful reconstruction of supercritical peripheral nerve injuries remains a major challenge in modern medicine. Progress in tissue engineering has enabled the development of nerve guidance conduits as an alternative to autologous ne…
View article: Automated image analysis of stained cytospins to quantify Schwann cell purity and proliferation
Automated image analysis of stained cytospins to quantify Schwann cell purity and proliferation Open
In response to injury, adult Schwann cells (SCs) re-enter the cell cycle, change their expression profile, and exert repair functions important for wound healing and the re-growth of axons. While this phenotypical instability of SCs is ess…
View article: Abstract 192: Silk Fibroin Based Conduits Filled With Native Spider Silk Fibers Successfully Promoted Nerve Regeneration In A 10 Mm Sciatic Nerve Defect In Rats
Abstract 192: Silk Fibroin Based Conduits Filled With Native Spider Silk Fibers Successfully Promoted Nerve Regeneration In A 10 Mm Sciatic Nerve Defect In Rats Open
Purpose: The surgical repair of nerve transection injuries remains a challenging task and often results in unsatisfactory functional recovery. If a direct coaptation is not possible, the current gold-standard is the use of an autograft. Ho…
View article: Adipose Stem Cell-Derived Extracellular Vesicles Induce Proliferation of Schwann Cells via Internalization
Adipose Stem Cell-Derived Extracellular Vesicles Induce Proliferation of Schwann Cells via Internalization Open
Recent studies showed a beneficial effect of adipose stem cell-derived extracellular vesicles (ADSC-EVs) on sciatic nerve repair, presumably through Schwann cell (SC) modulation. However, it has not yet been elucidated whether ADSC-EVs exe…
View article: Co-Culturing Human Adipose Derived Stem Cells and Schwann Cells on Spider Silk—A New Approach as Prerequisite for Enhanced Nerve Regeneration
Co-Culturing Human Adipose Derived Stem Cells and Schwann Cells on Spider Silk—A New Approach as Prerequisite for Enhanced Nerve Regeneration Open
Fast recovery is crucial for a successful nerve repair and an optimal functional outcome after peripheral nerve injury. Regarding donor site morbidity, autologous transplantation shows great limitations, which urge the need for alternative…
View article: Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes
Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes Open
Our results demonstrated for the first time that diacerein intensively intervenes in the regulation of FAK and STAT3 and influences components considered relevant for the progression of OA, even in the presence of mechanical stimulation.