Anders E. Lind
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View article: Novel<i>TPR::ROS1</i>Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma
Novel<i>TPR::ROS1</i>Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma Open
We have mapped the activated oncogenic pathways of a novel ROS1-fusion gene and broadened the knowledge of the newly recognized infant-type glioma subtype. The finding facilitates suitable targeted therapies for the patient in case of rela…
View article: Hikarchaeia demonstrate an intermediate stage in the methanogen-to-halophile transition
Hikarchaeia demonstrate an intermediate stage in the methanogen-to-halophile transition Open
Halobacteria (henceforth: Haloarchaea) are predominantly aerobic halophiles that are thought to have evolved from anaerobic methanogens. This remarkable transformation most likely involved an extensive influx of bacterial genes. Whether it…
View article: Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea
Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea Open
Genomic reconstruction from hot spring sediment metagenomes show that 'Hadesarchaea' have streamlined yet metabolically versatile genomes, with genes involved in CO and H2 oxidation, with potential coupling to nitrite reduction to ammonia.
View article: Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss Open
Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspe…
View article: Confident phylogenetic identification of uncultured prokaryotes through long read amplicon sequencing of the 16S‐ITS‐23S rRNA operon
Confident phylogenetic identification of uncultured prokaryotes through long read amplicon sequencing of the 16S‐ITS‐23S rRNA operon Open
Summary Amplicon sequencing of the 16S rRNA gene is the predominant method to quantify microbial compositions and to discover novel lineages. However, traditional short amplicons often do not contain enough information to confidently resol…
View article: Genomes of two archaeal endosymbionts show convergent adaptations to an intracellular lifestyle
Genomes of two archaeal endosymbionts show convergent adaptations to an intracellular lifestyle Open
Endosymbiosis is a widespread phenomenon in the microbial world and can be based on diverse interactions between endosymbiont and host cell. The vast majority of the known endosymbiotic interactions involve bacteria that have invaded eukar…
View article: Culture-independent methods and high-throughput sequencing applied to evolutionary microbial genomics
Culture-independent methods and high-throughput sequencing applied to evolutionary microbial genomics Open
Culture-independent methods allow us to better understand the diversity of microorganisms on earth. By omitting the culturing step, we can gain access to species previously out of our reach. To better capture and understand the diversity o…
View article: Amplicon sequencing of the 16S-ITS-23S rRNA operon with long-read technology for improved phylogenetic classification of uncultured prokaryotes
Amplicon sequencing of the 16S-ITS-23S rRNA operon with long-read technology for improved phylogenetic classification of uncultured prokaryotes Open
Amplicon sequencing of the 16S rRNA gene is the predominant method to quantify microbial compositions of environmental samples and to discover previously unknown lineages. Its unique structure of interspersed conserved and variable regions…
View article: Erratum: Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea
Erratum: Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea Open
Nature Microbiology 1, 16002 (2016); published 15 February 2016; corrected 6 June 2016. This Letter should have been published under a Creative Commons licence according to the Nature policy on publishing the primary sequence of an organis…
View article: Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea
Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea Open
The subsurface biosphere is largely unexplored and contains a broad diversity of uncultured microbes 1 . Despite being one of the few prokaryotic lineages that is cosmopolitan in both the terrestrial and marine subsurface 2–4 , the physiol…