Anders Esberg
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View article: Oral microbiota in an aging Swedish population with high dental disease burden: an observational registry-based study
Oral microbiota in an aging Swedish population with high dental disease burden: an observational registry-based study Open
Introduction The global population is aging. Although aging populations experience a high burden of dental and systemic diseases, few studies have described the oral microbiota in aging population-based cohorts. This observational, registr…
View article: Plasma and Urinary TMAO and Methylamine Responses to Meat and Egg Ingestion: Links to Gut Microbiota Composition in Subjects With and Without Metabolic Syndrome
Plasma and Urinary TMAO and Methylamine Responses to Meat and Egg Ingestion: Links to Gut Microbiota Composition in Subjects With and Without Metabolic Syndrome Open
Background/Objectives: Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite from L-carnitine and choline (abundant in meat and eggs), is linked to CVD and T2D. This study investigated whether TMAO responses to animal-based fo…
View article: Impact of bovine lactoferrin supplementation and reduced iron in formula on infant oral microbiome: a randomized controlled trial
Impact of bovine lactoferrin supplementation and reduced iron in formula on infant oral microbiome: a randomized controlled trial Open
The effects of reduced iron levels and lactoferrin supplementation of infant formula on the oral microbiome were inconclusive.
View article: Introduction to genome-wide association studies: Exploring their utility in caries and periodontitis
Introduction to genome-wide association studies: Exploring their utility in caries and periodontitis Open
Genome-Wide Association Studies (GWAS) are the primary method used to investigate the effects of common genetic variants on health and disease and are increasingly used as an arena for applied epidemiological methods. There are now a growi…
View article: Plasma TMAO Concentrations and Gut Microbiota Composition in Subjects with and Without Metabolic Syndrome: Results from Pilot Study
Plasma TMAO Concentrations and Gut Microbiota Composition in Subjects with and Without Metabolic Syndrome: Results from Pilot Study Open
Background/Objectives: Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite considered as a risk metabolite for various non-communicable diseases. This study aims to identify differences in the gut microbiota composition …
View article: The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity
The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity Open
Introduction Periodontitis is associated with rheumatoid arthritis (RA). One hypothesis posits that this connection arises from the formation of autoantibodies against citrullinated proteins (ACPA) in inflamed gums, possibly triggered by P…
View article: Saliva microbiome profiling by full-gene 16S rRNA Oxford Nanopore Technology versus Illumina MiSeq sequencing
Saliva microbiome profiling by full-gene 16S rRNA Oxford Nanopore Technology versus Illumina MiSeq sequencing Open
Molecular characterization of the oral microbiome is a crucial first step in experiments which aim to understand the complex dynamics of the oral microbiome or the interplay with host health and disease. Third-generation Oxford Nanopore Te…
View article: A Data‐Driven Approach Identifies Subtypes of Caries From Dental Charting
A Data‐Driven Approach Identifies Subtypes of Caries From Dental Charting Open
Objectives The objectives were to: (i) assess the accuracy of dental data for adults obtained from the Swedish Quality Register on Caries and Periodontitis (SKaPa); (ii) explore whether Latent Class Analysis (LCA) can identify groups of pe…
View article: The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis
The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis Open
The sequalae of periodontitis include irreversible degradation of tooth-supporting structures and circulatory spread of inflammatory mediators. However, the serum protein profile in periodontitis is not well described, which is partly attr…
View article: A Polygenic Score Predicts Caries Experience in Elderly Swedish Adults
A Polygenic Score Predicts Caries Experience in Elderly Swedish Adults Open
Caries is a partially heritable disease, raising the possibility that a polygenic score (PS, a summary of an individual’s genetic propensity for disease) might be a useful tool for risk assessment. To date, PS for some diseases have shown …
View article: <scp>LIGHT</scp> protein: A novel gingival crevicular fluid biomarker associated with increased probing depth after periodontal surgery
<span>LIGHT</span> protein: A novel gingival crevicular fluid biomarker associated with increased probing depth after periodontal surgery Open
Aim To evaluate the protein profiles in gingival crevicular fluid (GCF) in relation to clinical outcomes after periodontal surgery and examine if any selected proteins affect the mRNA expression of pro‐inflammatory cytokines in human gingi…
View article: Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults
Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults Open
Dicarbonyl compounds are highly reactive precursors of advanced glycation end products (AGE), produced endogenously, present in certain foods and formed during food processing. AGE contribute to the development of adverse metabolic outcome…
View article: Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity
Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity Open
Prolonged use of antibacterial mouthwash is linked to increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice…
View article: Differential Responders to a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota—Data from the MEDGI-Carb Randomized Controlled Trial
Differential Responders to a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota—Data from the MEDGI-Carb Randomized Controlled Trial Open
The global prevalence of type 2 diabetes mellitus (T2DM) has surged in recent decades, and the identification of differential glycemic responders can aid tailored treatment for the prevention of prediabetes and T2DM. A mixed meal tolerance…
View article: Differential Responders of a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota- Data from the MEDGI-Carb Randomized Controlled Trial
Differential Responders of a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota- Data from the MEDGI-Carb Randomized Controlled Trial Open
The global prevalence of type 2 diabetes mellitus (T2DM) has surged in recent decades and the identification of differential glycemic responders can aid tailored treatment for prevention of pre-diabetes and T2DM. A mixed meal tolerance tes…
View article: Household, dietary, and clinical characteristics of childhood caries and overweight progression—A prospective cohort study
Household, dietary, and clinical characteristics of childhood caries and overweight progression—A prospective cohort study Open
Background Childhood caries and obesity are complex chronic diseases with negative health outcomes. Aim This study sought a risk profile for childhood caries and overweight. Design Children were recruited into a longitudinal prospective co…
View article: Genetic Preference for Sweet Taste in Mothers Associates with Mother-Child Preference and Intake
Genetic Preference for Sweet Taste in Mothers Associates with Mother-Child Preference and Intake Open
Taste perception is a well-documented driving force in food selection, with variations in, e.g., taste receptor encoding and glucose transporter genes conferring differences in taste sensitivity and food intake. We explored the impact of m…
View article: Evidence for clinical subtypes of early childhood caries
Evidence for clinical subtypes of early childhood caries Open
The current early childhood caries (ECC) case definition contains a substantial degree of clinical heterogeneity, and to address this, we sought to identify clinical subtypes of the disease. We used tooth surface-level dental caries experi…
View article: Subtypes of early childhood caries predict future caries experience
Subtypes of early childhood caries predict future caries experience Open
Objectives To test whether postulated subtypes of early childhood caries (ECC) are predictive of subsequent caries experience in a population‐based cohort of Swedish children. Methods The study included children aged between 3 and 5 years …
View article: The breast milk and childhood gastrointestinal microbiotas and disease outcomes: a longitudinal study
The breast milk and childhood gastrointestinal microbiotas and disease outcomes: a longitudinal study Open
Background We aimed to characterize breast milk microbiota and define associations with saliva and fecal microbiota and selected diseases in preschool children. Methods In a longitudinal cohort study, the microbiotas from breast milk, mout…
View article: Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (<scp>EPIC</scp>)
Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (<span>EPIC</span>) Open
Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nut…
View article: Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study
Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study Open
In the European region, which shares 22.8% of the global cancer burden for 10% of the global population, there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020 [1]. The reasons for the high cancer inciden…
View article: Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis
Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis Open
Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral micr…
View article: Site- and Time-Dependent Compositional Shifts in Oral Microbiota Communities
Site- and Time-Dependent Compositional Shifts in Oral Microbiota Communities Open
Objectives The oral microbiota plays a significant role in oral health. The present study aims to characterize variations in the oral microbiota relative to the collection site, the dynamics of biofilm accumulation, and inherent inter-indi…
View article: Subtypes of early childhood caries predict future caries experience
Subtypes of early childhood caries predict future caries experience Open
Objectives To test whether postulated subtypes of early childhood caries (ECC) are predictive of subsequent caries experience in a population-based cohort of Swedish children. Methods The study included children aged between 3 and 5 years …
View article: Multilocus Sequence Typing of Non-JP2 Serotype b Aggregatibacter actinomycetemcomitans Strains of Ghanaian and Swedish Origin
Multilocus Sequence Typing of Non-JP2 Serotype b Aggregatibacter actinomycetemcomitans Strains of Ghanaian and Swedish Origin Open
Objective and Methods The Gram-negative bacterium, Aggregatibacter actinomycetemcomitans is associated with periodontitis affecting young individuals. The geographic dissemination of the highly leukotoxic JP2 genotype of serotype b of this…
View article: Healthy Oral Lifestyle Behaviours Are Associated with Favourable Composition and Function of the Oral Microbiota
Healthy Oral Lifestyle Behaviours Are Associated with Favourable Composition and Function of the Oral Microbiota Open
Modifiable lifestyle interventions may influence dental disease by shifting the composition of the oral microbiota. This study aimed to test whether lifestyle traits are associated with oral microbiota composition and function. Swedish vol…
View article: Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study Open
Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol…