Anders Etzerodt
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View article: <scp>LRP2</scp> Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by <scp>IFNy</scp> Signaling
<span>LRP2</span> Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by <span>IFNy</span> Signaling Open
Low density lipoprotein receptor‐related protein 2 (LRP2) is a 600 kilodalton multi‐ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and in select absorptive epit…
View article: Influenza A virus subverts the LC3-pericentrin dynein adaptor complex for host cytoplasm entry
Influenza A virus subverts the LC3-pericentrin dynein adaptor complex for host cytoplasm entry Open
Influenza A virus (IAV) enters host cells via endocytosis, and fusion of the viral particles (VPs) at endosomes releases the viral ribonucleoproteins (vRNPs) into the cytoplasm. This uncoating step that is vital for IAV infection remains t…
View article: Targeted delivery of RNA-based therapeutics enables functional analysis of macrophage subpopulations
Targeted delivery of RNA-based therapeutics enables functional analysis of macrophage subpopulations Open
Macrophages infiltrate all human tissues where they play key roles in innate immunity, homeostasis, and tissue function. However, extensive clinical and experimental evidence indicates that macrophages also contribute significantly to the …
View article: Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins Open
Targeted protein degradation (TPD) using PROteolysis TArgeting Chimeras (PROTACs) is a rapidly emerging therapeutic strategy for difficult-to-drug cytosolic proteins. PROTACs are heterobifunctional small molecules that bridge the target wi…
View article: LRP2 expression in melanoma is associated with a transitory cell state, increased T cell infiltration, and is upregulated by IFNγ signaling
LRP2 expression in melanoma is associated with a transitory cell state, increased T cell infiltration, and is upregulated by IFNγ signaling Open
Low density lipoprotein receptor-related protein 2 (LRP2) is a 600 kilodalton multi-ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and in select absorptive epit…
View article: In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade
In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade Open
In vitro tumor conditioning did not reduce the phagocytic response to CD47 blockade, suggesting that induction of a macrophage phenotype with increased expression of CD163 does not directly limit the capacity for phagocytosis of tumor cell…
View article: Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review
Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review Open
Tumor-associated macrophages (TAMs) play crucial roles in development and progression of malignant diseases. Notably, CD163+ TAMs likely perform specific pro-tumorigenic functions, suggesting that this subset may serve as both prognostic b…
View article: Defining the vascular niche of human adipose tissue across metabolic states
Defining the vascular niche of human adipose tissue across metabolic states Open
Introduction Adipose tissue homeostasis depends on a healthy vascular network. Vascular malfunction is a hallmark of obesity 1 , and vascular endothelial dysfunction, in particular, accelerates metabolic diseases, including obesity and dia…
View article: Migrasomes should not be classified as extracellular vesicles
Migrasomes should not be classified as extracellular vesicles Open
Cellular migration requires involvement of several different structures and cellular pathways that allow the cell to sense the surrounding environment and move through it. During migration, retraction fibers (RFs) are left behind the trail…
View article: Proinflammatory polarization strongly reduces human macrophage in vitro phagocytosis of tumor cells in response to CD47 blockade
Proinflammatory polarization strongly reduces human macrophage in vitro phagocytosis of tumor cells in response to CD47 blockade Open
Antibody‐based CD47 blockade aims to activate macrophage phagocytosis of tumor cells. However, macrophages possess a high degree of phenotype heterogeneity that likely influences phagocytic capacity. In murine models, proinflammatory (M1) …
View article: Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease Open
Alpha-synuclein (α-syn) aggregation and immune activation represent hallmark pathological events in Parkinson’s disease (PD). The PD-associated immune response encompasses both brain and peripheral immune cells, although little is known ab…
View article: CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier Open
In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have largely been explored in the context of pain, nerve injury, and repair. However, we discovered that most DRG macrophages interact with and monitor the vascu…
View article: Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance Open
Mild rupture of aged erythrocytes occurs physiologically in the spleen, leading to the release of hemoglobin (Hb), while pathological hemolysis characterizes several diseases. The detoxification of Hb has traditionally been attributed to t…
View article: T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy Open
A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majo…
View article: Comparison of culture media reveals that non‐essential amino acids strongly affect the phenotype of human monocyte‐derived macrophages
Comparison of culture media reveals that non‐essential amino acids strongly affect the phenotype of human monocyte‐derived macrophages Open
Macrophages are important innate immune cells with the ability to adapt their phenotype to environmental cues. Research on human macrophages often uses monocyte‐derived macrophages cultured in vitro, but it is unclear if culture medium aff…
View article: Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy Open
Background Primary and secondary resistance is a major hurdle in cancer immunotherapy. Therefore, a better understanding of the underlying mechanisms involved in immunotherapy resistance is of pivotal importance to improve therapy outcome.…
View article: T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy Open
Summary A key phenomenon in cancer is the establishment of a highly immunosuppressive tumor microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumor recognition and hence hereof tumor eradication, the…
View article: Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease Open
Alpha-synuclein (α-syn) aggregation and immune activation represent hallmark pathological events in Parkinson’s disease (PD). The PD-associated immune response encompasses both brain and peripheral immune cells, although little is known ab…
View article: Soluble <scp>CD163</scp> Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease
Soluble <span>CD163</span> Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease Open
Background Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as demonstrated by changes in immune biomarkers in patients' biofluids. However, which specific cells are responsible for those change…
View article: Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer
Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer Open
Recent evidence has highlighted the presence of neuronal nerve processes in the tumor microenvironment. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via…
View article: Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer Open
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny and function of TAM subsets in a mouse model of metastatic ovarian ca…
View article: Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression Open
Tumor-associated macrophages (TAMs) play critical roles in tumor progression but are also capable of contributing to antitumor immunity. Recent studies have revealed an unprecedented heterogeneity among TAMs in both human cancer and experi…
View article: <p>Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol</p>
Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol Open
Our results show that calcitriol can be effectively targeted to M. Our data confirms the anti-inflammatory properties of calcitriol and this may be a potential way to deliver high dose bioactive calcitriol to M during inflammation in vivo.