Anders Frost
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View article: Bone formation in interleukin‐4 and interleukin‐13 depleted mice
Bone formation in interleukin‐4 and interleukin‐13 depleted mice Open
Depletion of IL-4 and IL-13 does not cause any major alteration in fracture healing or heterotopic bone formation in mice. The pattern of autonomous nerve expression and expression of markers of neovascularization is, however, altered to s…
View article: Reduced cortical bone mass in mice with inactivation of interleukin‐4 and interleukin‐13
Reduced cortical bone mass in mice with inactivation of interleukin‐4 and interleukin‐13 Open
The aim of the present study was to study the in vivo role of IL‐4 and IL‐13 on bone metabolism. The skeletal phenotypes of male and female IL‐13 −/− ( n = 7+7), IL‐4 −/− IL‐13 −/− ( n = 7+7), and WT ( n = 7+7) mice were compared. Analysis…
View article: Interleukin‐4 and interleukin‐13 potentiate interleukin‐1 induced secretion of interleukin‐6 in human osteoblast‐like cells
Interleukin‐4 and interleukin‐13 potentiate interleukin‐1 induced secretion of interleukin‐6 in human osteoblast‐like cells Open
Formation of interleukin‐6 (IL‐6) in osteoblasts and bone marrow stromal cells is believed to regulate osteoclast recruitment. The anti‐inflammatory cytokines interleukin‐4 and −13 (IL‐4 and IL‐13) stimulate IL‐6 production in human osteob…
View article: Interleukin-13 Inhibits Cell Proliferation and Stimulates Interleukin-6 Formation in Isolated Human Osteoblasts<sup>1</sup>
Interleukin-13 Inhibits Cell Proliferation and Stimulates Interleukin-6 Formation in Isolated Human Osteoblasts<sup>1</sup> Open
Interleukin-13 (IL-13) is a recently identified cytokine that is secreted by activated T cells and regulates inflammatory responses. We have investigated the effects of IL-13 on isolated human osteoblast-like cells (hOB). IL-13 dose-depend…
View article: Inflammatory cytokines regulate proliferation of cultured human osteoblasts
Inflammatory cytokines regulate proliferation of cultured human osteoblasts Open
We investigated the effects of various pro-inflammatory cytokines on the proliferation rate of isolated human osteoblastic cells in primary cultures. Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-beta (TNF-beta) time- and dose-d…