Anders Hviid
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View article: Cardiovascular Events 1 Year After Respiratory Syncytial Virus Infection in Adults
Cardiovascular Events 1 Year After Respiratory Syncytial Virus Infection in Adults Open
Importance Respiratory syncytial virus (RSV) infection has recently been recognized as common among adults, but data on the burden of cardiovascular disease (CVD) beyond the immediate acute phase are lacking. Objective To estimate the 365-…
View article: Utilization patterns and determinants of guideline-recommended therapies for acute heart failure in Denmark
Utilization patterns and determinants of guideline-recommended therapies for acute heart failure in Denmark Open
Aims Acute heart failure (AHF) is a leading cause of frequent hospitalizations and poor outcomes. While chronic HF is treated with guideline-directed medical therapy, acute hospital care often requires loop diuretics, vasodilators, inotrop…
View article: Brand-specific influenza vaccine effectiveness in three Nordic countries during the 2024–2025 season: a target trial emulation study based on registry data
Brand-specific influenza vaccine effectiveness in three Nordic countries during the 2024–2025 season: a target trial emulation study based on registry data Open
View article: COVID-19 versus influenza burden in Denmark in the 2024–25 season
COVID-19 versus influenza burden in Denmark in the 2024–25 season Open
View article: Initiation of SGLT2 inhibitors versus mineralocorticoid receptor antagonists as third-line therapy in heart failure with reduced ejection fraction: a nationwide cohort study
Initiation of SGLT2 inhibitors versus mineralocorticoid receptor antagonists as third-line therapy in heart failure with reduced ejection fraction: a nationwide cohort study Open
View article: Angiotensin Receptor-Neprilysin Inhibitors and Mortality Among Patients With HFrEF
Angiotensin Receptor-Neprilysin Inhibitors and Mortality Among Patients With HFrEF Open
While trial evidence supports the benefit of angiotensin receptor-neprilysin inhibitor (ARNI) therapy in heart failure with reduced ejection fraction (HFrEF), its effectiveness in routine clinical practice is less explored. This study inve…
View article: Safety of <scp>BNT162b2 mRNA COVID</scp> ‐19 Vaccine Batches: A Nationwide Cohort Study
Safety of <span>BNT162b2 mRNA COVID</span> ‐19 Vaccine Batches: A Nationwide Cohort Study Open
Objectives The safety of the BNT162b2 mRNA COVID‐19 vaccine has been extensively evaluated since the global rollout began. While serious adverse events are rare, safety issues continue to arise. This study evaluates the claim that earlier …
View article: Safety of JN.1-Updated mRNA COVID-19 Vaccines
Safety of JN.1-Updated mRNA COVID-19 Vaccines Open
This cohort study investigates the association between booster vaccinations containing the JN.1 lineage and 29 serious adverse events in Denmark.
View article: Long-term effects on cardiac function and symptoms in patients with myocarditis following COVID-19 vaccination: the ECHOVID-19 Long-term Study
Long-term effects on cardiac function and symptoms in patients with myocarditis following COVID-19 vaccination: the ECHOVID-19 Long-term Study Open
Background The long-term effects of myocarditis following COVID-19 vaccination on cardiac function and symptoms remain unclear. Purpose To assess the long-term effects of myocarditis following COVID-19 vaccination on cardiac function, infl…
View article: Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden
Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden Open
The novel COVID-19 severity index associated with all-cause 90-day mortality and aligned with previous literature. This index will enable comparative studies of COVID-19, which is important for public health policies and development of cli…
View article: Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study
Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study Open
In this large multinational study, we found increased risks of GBS within 42 days after Vaxzevria/Covishield vaccination or SARS-CoV-2 infection, and decreased risks after receiving Comirnaty/Tozinameran or CoronaVac/Sinovac COVID-19 vacci…
View article: Off-the-Shelf Large Language Models for Causality Assessment of Individual Case Safety Reports: A Proof-of-Concept with COVID-19 Vaccines
Off-the-Shelf Large Language Models for Causality Assessment of Individual Case Safety Reports: A Proof-of-Concept with COVID-19 Vaccines Open
View article: Association between Covid-19 BNT162b2 vaccination or SARS-CoV-2 infection and immune mediated diseases in 5 million 5-to-19-year-olds in four Nordic countries
Association between Covid-19 BNT162b2 vaccination or SARS-CoV-2 infection and immune mediated diseases in 5 million 5-to-19-year-olds in four Nordic countries Open
Background We investigated new onset of autoimmune hepatitis (AH), Guillain-Barré syndrome (GBS) and Type 1 Diabetes (T1D), and potential increased disease activity (measured as recurrent hospital visits) of Juvenile Rheumatoid Arthritis (…
View article: Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics
Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics Open
Key Points This large-scale genetic study identified 31 loci associated with plasma sodium concentrations in individuals of European ancestry. Tissue specificity analysis showed a significantly increased expression of sodium-associated gen…
View article: SARS-CoV-2 Infection and Long-Term Risk of Cardiovascular and Renal Morbidity
SARS-CoV-2 Infection and Long-Term Risk of Cardiovascular and Renal Morbidity Open
Importance Cardiovascular and renal consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been studied intensively in high-risk groups, but the consequences of mild infection for the general population…
View article: Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden
Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden Open
View article: Antidepressant exposure patterns during pregnancy and risk of adverse newborn outcomes
Antidepressant exposure patterns during pregnancy and risk of adverse newborn outcomes Open
Studies on antidepressant use during pregnancy often rely on a simplified exposure classification. We introduce a novel data-driven method to identify complex antidepressant exposure patterns during pregnancy and estimates the risk of 24-h…
View article: Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants Open
The host genetics of SARS-CoV-2 has previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and/or severity. SARS-CoV-2 has shown rapid sequence …
View article: SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction: linked database study
SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction: linked database study Open
Objective To investigate the association between sodium-glucose cotransporter-2 (SGLT-2) inhibitor use and risk of all cause mortality among patients with heart failure with reduced ejection fraction. Design Linked database study. Setting …
View article: Comparative effectiveness of monovalent XBB.1.5 containing covid-19 mRNA vaccines in Denmark, Finland, and Sweden: target trial emulation based on registry data
Comparative effectiveness of monovalent XBB.1.5 containing covid-19 mRNA vaccines in Denmark, Finland, and Sweden: target trial emulation based on registry data Open
Objective To estimate the effectiveness of vaccination with a monovalent covid-19 mRNA vaccine containing the omicron XBB.1.5 subvariant against severe covid-19 disease in Denmark, Finland, and Sweden. Design Target trial emulation based o…
View article: Predicting High Excess Risk of Hyponatremia Among Thiazide Users
Predicting High Excess Risk of Hyponatremia Among Thiazide Users Open
Importance: Hyponatremia is a potential serious adverse drug reaction to treatment with thiazide diuretics. Whether individuals with a high risk of developing thiazide-induced hyponatremia can be predicted before treatment initiation is un…
View article: Post–COVID-19 Condition Fatigue Outcomes Among Danish Residents
Post–COVID-19 Condition Fatigue Outcomes Among Danish Residents Open
Importance Fatigue remains one of the most common and debilitating symptoms of post–COVID-19 condition; however, existing studies are limited to select populations and often lack noninfected controls. It also remains unclear to what extent…
View article: Human papillomavirus nonavalent (HPV9) vaccination and risk of immune mediated diseases, myocarditis, pericarditis, and thromboembolic outcomes in Denmark: self-controlled case series study
Human papillomavirus nonavalent (HPV9) vaccination and risk of immune mediated diseases, myocarditis, pericarditis, and thromboembolic outcomes in Denmark: self-controlled case series study Open
Objective To assess the associations between vaccination with the nonavalent human papillomavirus (HPV9) vaccine and immune mediated diseases, myocarditis, pericarditis, arterial thromboembolism, and venous thromboembolism with or without …
View article: GLP-1 Receptor Agonist Use and Risk of Suicide Death
GLP-1 Receptor Agonist Use and Risk of Suicide Death Open
Importance Concerns have been raised regarding a link between use of glucagon-like peptide-1 (GLP-1) receptor agonists and increased risk of suicidality and self-harm. Objective To assess the association between use of GLP-1 receptor agoni…
View article: Comparative effectiveness of bivalent BA.4–5 or BA.1 mRNA booster vaccines among immunocompromised individuals across three Nordic countries: A nationwide cohort study
Comparative effectiveness of bivalent BA.4–5 or BA.1 mRNA booster vaccines among immunocompromised individuals across three Nordic countries: A nationwide cohort study Open
In immunocompromised individuals, vaccination with bivalent BA.4-5 or BA.1 booster lowered the risk of Covid-19-related hospitalization and death over a follow-up period of 9 months. The effectiveness was highest during the first months si…
View article: tame: An R package for identifying clusters of medication use based on dose, timing and type of medication
tame: An R package for identifying clusters of medication use based on dose, timing and type of medication Open
Simplified exposure classifications, such as ever exposed versus never exposed, are commonly used in pharmacoepidemiology. However, this simplification may obscure complex use patterns relevant to researchers. We introduce tame, an R packa…
View article: Comparative cardiovascular and renal effectiveness of empagliflozin and dapagliflozin: Scandinavian cohort study
Comparative cardiovascular and renal effectiveness of empagliflozin and dapagliflozin: Scandinavian cohort study Open
Aims To assess the comparative cardiovascular and renal effectiveness and safety of empagliflozin vs. dapagliflozin among patients with type 2 diabetes in routine clinical practice. Methods and results Cohort study using data from nationwi…
View article: Comparative effectiveness of the monovalent XBB.1.5-containing covid-19 mRNA vaccine across three Nordic countries
Comparative effectiveness of the monovalent XBB.1.5-containing covid-19 mRNA vaccine across three Nordic countries Open
Objective To estimate the effectiveness of vaccination with a monovalent XBB.1.5-containing covid-19 mRNA vaccine against severe covid-19 across three Nordic countries. Design Nationwide cohort studies, using target trial emulation. Settin…
View article: Comparative effectiveness of bivalent BA.4.5 or BA.1 mRNA booster vaccines among immunocompromised individuals across three Nordic countries: a nationwide cohort study
Comparative effectiveness of bivalent BA.4.5 or BA.1 mRNA booster vaccines among immunocompromised individuals across three Nordic countries: a nationwide cohort study Open
Objectives To estimate the effectiveness and waning immunity of the bivalent BA.4-5 or BA.1 mRNA booster vaccine against Covid-19-related hospital admission and death in immunocompromised individuals. Design Nationwide cohort analyses usin…
View article: Cohort profile: EFTER-COVID – a Danish nationwide cohort for assessing the long-term health effects of the COVID-19 pandemic
Cohort profile: EFTER-COVID – a Danish nationwide cohort for assessing the long-term health effects of the COVID-19 pandemic Open
Purpose To follow SARS-CoV-2-infected persons up to 18 months after a positive test in order to assess the burden and nature of post acute symptoms and health problems. Participants Persons in Denmark above 15 years of age, who were tested…