Anders Karlsen
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View article: Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals Open
Aging is associated with declines in muscle mass, strength, aerobic capacity, and metabolic health, accompanied by increased low-grade inflammation. The purpose of this study was to assess the effects of 12 weeks of resistance training (RT…
View article: The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes
The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes Open
Training can improve insulin sensitivity in individuals with type 2 diabetes, but a clear understanding of the mechanisms remains elusive. To further our knowledge in this area, we aimed to examine the effect of type 2 diabetes and of high…
View article: Insulin‐like growth factor‐1 infusion in preterm piglets does not affect growth parameters of skeletal muscle or tendon tissue
Insulin‐like growth factor‐1 infusion in preterm piglets does not affect growth parameters of skeletal muscle or tendon tissue Open
Prematurity has physical consequences, such as lower birth weight, decreased muscle mass and increased risk of adult‐onset metabolic disease. Insulin‐like growth factor 1 (IGF‐1) has therapeutic potential to improve the growth and quality …
View article: Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training
Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training Open
Background Age‐related loss of strength is disproportionally greater than the loss of mass, suggesting maladaptations in the neuro‐myo‐tendinous system. Myofibers are often misshaped in aged and diseased muscle, but systematic analyses of …
View article: Marked irregular myofiber shape is a hallmark of human skeletal muscle aging and is reversed by heavy resistance training
Marked irregular myofiber shape is a hallmark of human skeletal muscle aging and is reversed by heavy resistance training Open
Background Age-related loss of strength is disproportionally greater than the loss of mass, suggesting maladaptations in the neuro-myo-tendinous system. Myofibers are often misshaped in aged and diseased muscle, but systematic analyses of …
View article: Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing
Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing Open
The myotendinous junction (MTJ) is a specialized domain of the multinucleated myofibre that is faced with the challenge of maintaining robust cell–matrix contact with the tendon under high mechanical stress and strain. Here, we profiled 24…
View article: Distinct myofibre domains of the human myotendinous junction revealed by single nucleus RNA-seq
Distinct myofibre domains of the human myotendinous junction revealed by single nucleus RNA-seq Open
The myotendinous junction (MTJ) is a specialized domain of the multinucleated myofibre, faced with the challenge of maintaining robust cell-matrix contact with the tendon under high mechanical stress and strain. Here, we profiled 24,161 nu…
View article: Aging is associated with an altered macrophage response during human skeletal muscle regeneration
Aging is associated with an altered macrophage response during human skeletal muscle regeneration Open
Skeletal muscle injury in aged rodents is characterized by an asynchronous infiltration of pro- and anti-inflammatory macrophage waves, leading to improper and incomplete regeneration. It is unclear whether this aberration also occurs in a…
View article: The proteomic profile of the human myotendinous junction
The proteomic profile of the human myotendinous junction Open
View article: Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity Open
View article: From Single Muscle Fibers to Specific Myofiber Domains: The Proteomic Profile of the Human Myotendinous Junction
From Single Muscle Fibers to Specific Myofiber Domains: The Proteomic Profile of the Human Myotendinous Junction Open
View article: Effects of alternating blood flow restricted training and heavy-load resistance training on myofiber morphology and mechanical muscle function
Effects of alternating blood flow restricted training and heavy-load resistance training on myofiber morphology and mechanical muscle function Open
The present data demonstrate that periodically substituting heavy-load resistance training (HL-RT) with low-load blood flow restricted resistance training (BFR-RT) leads to similar gains in type II myofiber CSA and muscle strength as achie…
View article: Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise
Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise Open
The decline in muscle mass and function with age is partly caused by a loss of muscle fibres through denervation. The purpose of this study was to investigate the potential of exercise to influence molecular targets involved in neuromuscul…
View article: Time course of natural heat acclimatization in well‐trained cyclists during a 2‐week training camp in the heat
Time course of natural heat acclimatization in well‐trained cyclists during a 2‐week training camp in the heat Open
The aim of this study was to determine the time course of physiological adaptations and their relationship with performance improvements during 2 weeks of heat acclimatization. Nine trained cyclists completed 2 weeks of training in natural…
View article: Heat acclimatization does not improve VO<sub>2max</sub> or cycling performance in a cool climate in trained cyclists
Heat acclimatization does not improve VO<sub>2max</sub> or cycling performance in a cool climate in trained cyclists Open
This study investigated if well‐trained cyclists improve and performance in cool conditions following heat acclimatization through natural outdoor training in hot conditions. Eighteen trained male cyclists were tested for physiological ada…