Anders Kvanta
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View article: Long-Term Natural History of Treatment-Naïve Geographic Atrophy in Age-Related Macular Degeneration
Long-Term Natural History of Treatment-Naïve Geographic Atrophy in Age-Related Macular Degeneration Open
By analyzing the data of one of the most extensive geographic atrophy patient cohorts in the Nordics, this study establishes a dataset on the long-term treatment-naïve growth dynamics. It provides a reference for upcoming preclinical treat…
View article: VEGF in Tears as a Biomarker for Exudative Age-Related Macular Degeneration: Molecular Dynamics in a Mouse Model and Human Samples
VEGF in Tears as a Biomarker for Exudative Age-Related Macular Degeneration: Molecular Dynamics in a Mouse Model and Human Samples Open
Vascular endothelial growth factor (VEGF) is a key mediator of exudative age-related macular degeneration (eAMD), yet non-invasive biomarkers for disease monitoring remain limited. This study evaluates VEGF levels in human tear fluid as a …
View article: Turn-Adopting Peptidomimetic as a Formyl Peptide Receptor-1 Antagonist
Turn-Adopting Peptidomimetic as a Formyl Peptide Receptor-1 Antagonist Open
The design, synthesis, and characterization of a new peptidomimetic acting as a formyl peptide receptor (FPR1) antagonist (N-19004) are herein reported. The molecule has been identified with docking studies of the highly potent FPR1 antago…
View article: Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema
Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema Open
This study analyzes the dynamics of short-term treatment response to the first intravitreal faricimab injection in eyes with diabetic macular edema (DME). This retrospective, single-center, clinical trial was conducted at the Department of…
View article: Accelerated maturation of <scp>ARPE</scp> ‐19 cells for the translational assessment of gene therapy
Accelerated maturation of <span>ARPE</span> ‐19 cells for the translational assessment of gene therapy Open
The human retinal pigment epithelium (RPE) cell line ARPE‐19 is widely used as an alternative to primary RPE despite losing many features of primary RPE. We aimed to determine whether a combination of RPE‐specific laminin (LN) and nicotina…
View article: Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration
Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration Open
Objectives: This study entailed a weekly analysis of real-world data (RWD) on the safety and efficacy of intravitreal (IVT) faricimab in neovascular age-related macular degeneration (nAMD). Methods: A retrospective, single-centre clinical …
View article: Mitigation of human iris angiogenesis through <scp>uPAR</scp> / <scp>LRP</scp> ‐1 interaction antagonism in an organotypic ex vivo model
Mitigation of human iris angiogenesis through <span>uPAR</span> / <span>LRP</span> ‐1 interaction antagonism in an organotypic ex vivo model Open
Rubeosis Iridis (RI) is characterized by an increase in neovascularization and inflammation factors in the iris. During angiogenesis, the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a pivotal role in extracellular ma…
View article: Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells Open
The possibility of cryopreserving the hPSC-RPE product has been instrumental in our efforts in manufacturing and performing pre-clinical testing with the aim for clinical translation.
View article: Novel subthreshold retinal laser treatment with ERG-based thermal dosimetry activates hormetic heat response in pig RPE<i>in vivo</i>
Novel subthreshold retinal laser treatment with ERG-based thermal dosimetry activates hormetic heat response in pig RPE<i>in vivo</i> Open
Boosting natural mechanisms to retain cellular homeostasis and combat oxidative stress by inducing a hormetic heat shock to retinal pigment epithelium with non-damaging transpupillary laser heating, i.e., with subthreshold laser treatment …
View article: Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells Open
To maintain homeostasis, cells have evolved stress-response pathways to cope with exogenous and endogenous stress factors. Diverse stresses at high doses may be detrimental, albeit low doses of stress, known as hormesis, can be beneficial.…
View article: An imbalance in autophagy contributes to retinal damage in a rat model of oxygen‐induced retinopathy
An imbalance in autophagy contributes to retinal damage in a rat model of oxygen‐induced retinopathy Open
In retinopathy of prematurity (ROP), the abnormal retinal neovascularization is often accompanied by retinal neuronal dysfunction. Here, a rat model of oxygen‐induced retinopathy (OIR), which mimics the ROP disease, was used to investigate…
View article: Echinomycin mitigates ocular angiogenesis by transcriptional inhibition of the hypoxia-inducible factor-1
Echinomycin mitigates ocular angiogenesis by transcriptional inhibition of the hypoxia-inducible factor-1 Open
Our data proposes EKN as a potent inhibitor of HIF-mediated angiogenesis in retinal cells and in the mouse model of CNV, which could have future implications in the treatment of patients with neovascular age-related macular degeneration.
View article: Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use
Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use Open
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, detailed single cell mapping of the transi…
View article: Autophagy Involvement in the Postnatal Development of the Rat Retina
Autophagy Involvement in the Postnatal Development of the Rat Retina Open
During retinal development, a physiologic hypoxia stimulates endothelial cell proliferation. The hypoxic milieu warrants retina vascularization and promotes the activation of several mechanisms aimed to ensure homeostasis and energy balanc…
View article: Publisher Correction: Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells
Publisher Correction: Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Nuclear expression of BAP-1 in transvitreal incisional biopsies and subsequent enucleation of eyes with posterior choroidal melanoma
Nuclear expression of BAP-1 in transvitreal incisional biopsies and subsequent enucleation of eyes with posterior choroidal melanoma Open
Background As a majority of patients with choroidal melanoma do not undergo enucleation, tumour tissue for prognostic testing has to be obtained with alternate methods. Transvitreal incisional biopsies enable histological examination as we…
View article: Publisher Correction: Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells
Publisher Correction: Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration
Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration Open
As pluripotent stem cell (PSC)-based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies…
View article: Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin Open
Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effect…
View article: Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cells
Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cells Open
With cell therapies advancing towards the patients’ bedside, there is an increased need for robust and up-scalable protocols to generate clinical grade stem cell-derived products.The protocol we present in the study provides a xeno-free, c…
View article: Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cells
Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cells Open
With cell therapies advancing towards the patients’ bedside, there is an increased need for robust and up-scalable protocols to generate clinical grade stem cell-derived products.The protocol we present in the study provides a xeno-free, c…