Anders Morten Grejs
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View article: Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial
Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial Open
NCT02908308.
View article: The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study
The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study Open
This analysis found that the cost-effectiveness of mild hypercapnia is highly uncertain when compared with normocapnia in adult patients following OHCA, with no significant differences in either costs or outcomes. Further research is requi…
View article: Effects of withdrawal of life-sustaining therapy on long-term neurological outcome after cardiac arrest − A multicentre matched cohort study
Effects of withdrawal of life-sustaining therapy on long-term neurological outcome after cardiac arrest − A multicentre matched cohort study Open
View article: Should Anaesthesiologists Be Taught to Perform Ultrasound‐Assisted Neuraxial Access in Spinal Anaesthesia?—Protocol of a Randomised Controlled Study
Should Anaesthesiologists Be Taught to Perform Ultrasound‐Assisted Neuraxial Access in Spinal Anaesthesia?—Protocol of a Randomised Controlled Study Open
Background Neuraxial blockade, typically guided by manual palpation, can be challenging in certain patient populations. Ultrasound‐assisted neuraxial access has the potential to improve success rates, particularly for novice anaesthesiolog…
View article: Assessment of Basic Skills in Ultrasound‐Based Neuraxial Access—A Protocol of a Study Gathering Validity Evidence
Assessment of Basic Skills in Ultrasound‐Based Neuraxial Access—A Protocol of a Study Gathering Validity Evidence Open
Background Neuraxial access procedures, such as spinal blocks, are routine but can be challenging in for example, obese, pregnant, and elderly patients. Ultrasound‐based techniques offer a promising alternative, yet standardized assessment…
View article: Training and assessment of skills in neuraxial space access: a scoping review of educational approaches to lumbar puncture, epidural anaesthesia, and spinal anaesthesia
Training and assessment of skills in neuraxial space access: a scoping review of educational approaches to lumbar puncture, epidural anaesthesia, and spinal anaesthesia Open
Studies on education in neuraxial space access show substantial variation in educational approaches and assessment. Consistent findings indicate that simulation-based training enhances outcomes across multiple Kirkpatrick levels, although …
View article: Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial Open
View article: Prediction of good functional outcome decreases diagnostic uncertainty in unconscious survivors after out-of-hospital cardiac arrest
Prediction of good functional outcome decreases diagnostic uncertainty in unconscious survivors after out-of-hospital cardiac arrest Open
View article: Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial: a post hoc analysis
Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial: a post hoc analysis Open
View article: Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial Open
Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, …
View article: Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial
Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial Open
View article: Comparison of self-reported physical activity between survivors of out-of-hospital cardiac arrest and patients with myocardial infarction without cardiac arrest: a case–control study
Comparison of self-reported physical activity between survivors of out-of-hospital cardiac arrest and patients with myocardial infarction without cardiac arrest: a case–control study Open
Aims To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of a…
View article: Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial
Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial Open
Very early hyperoxemia after ICU admission is associated with higher risk of poor functional outcome after OHCA. Avoiding hyperoxia in the initial hours after resuscitation should be considered.
View article: Magnetic resonance imaging in comatose adults resuscitated after out-of-hospital cardiac arrest: A posthoc study of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest trial
Magnetic resonance imaging in comatose adults resuscitated after out-of-hospital cardiac arrest: A posthoc study of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest trial Open
In the TAME trial, 9% of patients had an MRI during their intensive care unit admission. Among these patients, only 16% had a favourable neurological outcome at 6 months.
View article: Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study Open
View article: Low physical activity level in out-of-hospital cardiac arrest survivors with obesity, mobility problems and cognitive impairment: Results from the TTM2 trial
Low physical activity level in out-of-hospital cardiac arrest survivors with obesity, mobility problems and cognitive impairment: Results from the TTM2 trial Open
View article: Combined use of the Montreal Cognitive Assessment and Symbol Digit Modalities Test improves neurocognitive screening accuracy after cardiac arrest: A validation sub-study of the TTM2 trial
Combined use of the Montreal Cognitive Assessment and Symbol Digit Modalities Test improves neurocognitive screening accuracy after cardiac arrest: A validation sub-study of the TTM2 trial Open
View article: EEG for good outcome prediction after cardiac arrest: A multicentre cohort study
EEG for good outcome prediction after cardiac arrest: A multicentre cohort study Open
View article: Ultrasound in anesthesiology in the Nordic countries—Protocol of an international survey on availability, frequency of use, operator training, and certification
Ultrasound in anesthesiology in the Nordic countries—Protocol of an international survey on availability, frequency of use, operator training, and certification Open
Background Over the past decade, ultrasound utilization has increased within anesthesia and intensive care medicine, enhancing patient safety and diagnostic accuracy. However, the frequency of ultrasound usage and operator training in the …
View article: Sonographic evaluation of intracranial hemodynamics and pressure after out-of-hospital cardiac arrest: An exploratory sub-study of the TAME trial
Sonographic evaluation of intracranial hemodynamics and pressure after out-of-hospital cardiac arrest: An exploratory sub-study of the TAME trial Open
View article: Training and assessment of skills in neuraxial access—Protocol of a scoping review
Training and assessment of skills in neuraxial access—Protocol of a scoping review Open
Background Access to the neuraxial space, including lumbar punctures and neuraxial anaesthesia, is an everyday procedure in clinical practice. Traditionally these procedures rely on manual palpation technique, but ultrasound is a useful to…
View article: Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm
Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm Open
Importance International guidelines recommend body temperature control below 37.8 °C in unconscious patients with out-of-hospital cardiac arrest (OHCA); however, a target temperature of 33 °C might lead to better outcomes when the initial …
View article: Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials Open
View article: 1 Neuropsychological Outcome After Cardiac Arrest: Results from a Sub-study of the Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) Trial
1 Neuropsychological Outcome After Cardiac Arrest: Results from a Sub-study of the Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) Trial Open
Objective: To describe cognitive impairment in out-of-hospital cardiac arrest (OHCA) survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myo…
View article: Agreement between self‐reported and objectively assessed physical activity among out‐of‐hospital cardiac arrest survivors
Agreement between self‐reported and objectively assessed physical activity among out‐of‐hospital cardiac arrest survivors Open
Background Low level of physical activity is a risk factor for new cardiac events in out‐of‐hospital cardiac arrest (OHCA) survivors. Physical activity can be assessed by self‐reporting or objectively by accelerometery. Aim To investigate …
View article: Neuropsychological outcome after cardiac arrest: results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
Neuropsychological outcome after cardiac arrest: results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial Open
View article: Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest
Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest Open
View article: Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest
Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest Open
Importance The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This pre…
View article: Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest Open
In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. (Funded by the National Health and Medical Resear…
View article: Assessment of physical activity in out-of-hospital cardiac arrest survivors: a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
Assessment of physical activity in out-of-hospital cardiac arrest survivors: a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Riksförbundet HjärtLung Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research. Background Low physical activity is a risk factor for…