Explanipedia

Extracellular ATP is an environmental cue in bacteria Open

Sophie Tronnet, Vikash Pandey, Miriam Lloret-Berrocal, Mario Pérez-del-Pozo, Carlos Hernández-Ortego , et al. · 2025

In animals and plants, extracellular ATP (eATP) functions as a signal and regulates the immune response. During inflammation, intestinal bacteria are exposed to elevated eATP originating from the mucosa. However, whether bacteria respond t…

From algorithms to negotiations: Why health diplomacy must adapt Open

Brian Li Han Wong, Garry Aslanyan, Warisa Panichkriangkrai, Ricardo Baptista‐Leite, Jemilah Mahmood , et al. · 2025

Health diplomacy traditionally relies on consensus-building across nations, yet the accelerating integration of artificial intelligence (AI) into health systems poses new governance challenges. Rapidly changing geopolitical conditions—exem…

Navigating global health diplomacy: challenges and opportunities in building a community of practice Open

Paul R. Rosenbaum, Carita Rehn, Karl Wennberg, Anders Nordström, Tobias Alfvén · 2025

Mpox: Neglect has led to a more dangerous virus now spreading across borders, harming and killing people. Leaders must take action to stop mpox now Open

Christine McNab, Els Torreele, Ayoade Alakija, Aggrey Aluso, Mauricio Cárdenas , et al. · 2024

From polycrisis to metacrisis: harnessing windows of opportunity for renewed political leadership in global health diplomacy Open

Brian Li Han Wong, Anders Nordström, Peter Piot, Helen Clark · 2024

Extracellular ATP is an environmental cue in bacteria Open

Sophie Tronnet, Vikash Pandey, Miriam Lloret-Berrocal, Mario Pérez-del-Pozo, Niklas Söderholm , et al. · 2024

In animals and plants extracellular ATP (eATP) functions as signal and regulates the immune response. During inflammation intestinal bacteria are exposed to elevated eATP originating from the mucosa. However, whether bacteria respond to eA…

Referee report. For: Scoping review of international relations theories in health security: A cue for health diplomacy [version 1; peer review: 2 approved] Open

Anders Nordström · 2024

Characteristics of successful government-led interventions to support healthier populations: a starting portfolio of positive outlier examples Open

Peter Bragge, Alex Waddell, Paul Kellner, Veronica Delafosse, Robert Marten , et al. · 2023

Despite progress on the Millennium and Sustainable Development Goals, significant public health challenges remain to address communicable and non-communicable diseases and health inequities. The Healthier Societies for Healthy Populations …

Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming Open

Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris , et al. · 2023

Background Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeut…

Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2 Open

Philipp Rabe, Mareike Gehmlich, Anna Peters, Petra Krumbholz, Anders Nordström , et al. · 2022

Background The adaptation of cellular metabolism is considered a hallmark of cancer. Oncogenic signaling pathways support tumorigenesis and cancer progression through the induction of certain metabolic phenotypes associated with altered re…

Transforming or tinkering: the world remains unprepared for the next pandemic threat Open

Helen Clark, Mauricio Cárdenas, Mark Dybul, Michel D. Kazatchkine, Joanne Liu , et al. · 2022

Comparative structural analysis provides new insights into the function of R2‐like ligand‐binding oxidase Open

Riccardo Diamanti, Vivek Srinivas, Annika Johansson, Anders Nordström, Julia J. Griese , et al. · 2022

R2‐like ligand‐binding oxidase (R2lox) is a ferritin‐like protein that harbours a heterodinuclear manganese–iron active site. Although R2lox function is yet to be established, the enzyme binds a fatty acid ligand coordinating the metal cen…

Aggressive containment, suppression, and mitigation of covid-19: lessons learnt from eight countries Open

Shishi Wu, Rachel Neill, Chuan De Foo, Alvin Qijia Chua, Anne-Sophie Jung , et al. · 2021

Shishi Wu and colleagues examine three distinct response strategies for covid-19 in eight countries and argue that aggressive containment is the optimal approach to limiting loss of lives and livelihoods and achievable in the absence of va…

Investing in trust and community resilience: lessons from the early months of the first digital pandemic Open

Salma M. Abdalla, Shaffi Fazaludeen Koya, Margaret Jamieson, Monica Verma, Victoria Haldane , et al. · 2021

Salma M Abdalla and colleagues examine how an atmosphere of misinformation, disinformation, and erosion of trust shaped the early response to covid-19 on both global and national levels

Vaccines, therapeutics, and diagnostics for covid-19: redesigning systems to improve pandemic response Open

Rohit Ramchandani, Michel D. Kazatchkine, Joanne Liu, Preeti Sudan, Mark Dybul , et al. · 2021

Rohit Ramchandani and colleagues propose a framework to ensure essential public health tools are fairly distributed in future pandemics

Strengthening the basics: public health responses to prevent the next pandemic Open

Victoria Haldane, Anne-Sophie Jung, Chuan De Foo, Mathias Bonk, Margaret Jamieson , et al. · 2021

Victoria Haldane and colleagues argue that to make covid-19 the last pandemic, public health responses to outbreaks must be strengthened, starting with their most basic functions

National responses to covid-19: drivers, complexities, and uncertainties in the first year of the pandemic Open

Anne-Sophie Jung, Victoria Haldane, Rachel Neill, Shishi Wu, Margaret Jamieson , et al. · 2021

Anne-Sophie Jung and colleagues argue that research and policy making must embrace complexity to build sustainable and long term approaches to pandemic preparedness

From response to transformation: how countries can strengthen national pandemic preparedness and response systems Open

Victoria Haldane, Anne-Sophie Jung, Rachel Neill, Sudhvir Singh, Shishi Wu , et al. · 2021

Victoria Haldane and colleagues delve into the characteristics of national responses to covid-19. They suggest actionable steps at a national level that can guide states to achieve the independent panel’s recommendations for making this th…

Resetting international systems for pandemic preparedness and response Open

Sudhvir Singh, Michael Bartoš, Salma M. Abdalla, Helena Legido‐Quigley, Anders Nordström , et al. · 2021

Sudhvir Singh and colleagues summarise the recommendations of the Independent Panel for Pandemic Preparedness and Response to try to prevent future pandemics

From dichotomisation towards intersectionality in addressing covid-19 Open

Anne-Sophie Jung, Victoria Haldane, Rachel Neill, Melisa Mei Jin Tan, Salma M. Abdalla , et al. · 2021

Anne-Sophie Jung and colleagues argue that understanding mechanisms of response to the covid-19 pandemic as trade-offs reinforces false dichotomies and hamstrings attempts to create stronger and more equitable health systems

Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries Open

Victoria Haldane, Chuan De Foo, Salma M. Abdalla, Anne-Sophie Jung, Melisa Mei Jin Tan , et al. · 2021

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism Open

Magesh Muthu, Ranjeet Kumar, Azharuddin Sajid Syed Khaja, Jonathan D. Gilthorpe, Jenny L. Persson , et al. · 2019

Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cel…

Revitalization of integrated disease surveillance and response in Sierra Leone post Ebola virus disease outbreak Open

Charles Njuguna, Amara Jambai, Alexander Chimbaru, Anders Nordström, Roland Conteh , et al. · 2019

With proper planning, phased implementation and adequate investment of resources, it is possible to establish a functional IDSR system in a country recovering from a public health crisis. A functional IDSR system requires well trained work…

Current Status and Future Prospects of Clinically Exploiting Cancer-specific Metabolism—Why Is Tumor Metabolism Not More Extensively Translated into Clinical Targets and Biomarkers? Open

Magesh Muthu, Anders Nordström · 2019

Tumor cells exhibit a specialized metabolism supporting their superior ability for rapid proliferation, migration, and apoptotic evasion. It is reasonable to assume that the specific metabolic needs of the tumor cells can offer an array of…

Shifting global health governance towards the sustainable development goals Open

Robert Marten, Sowmya Kadandale, Anders Nordström, Richard Smith · 2018

Investing in sexual and reproductive health and rights of women and girls to reach HIV and UHC goals Open

Manjulaa Narasimhan, Yogan Pillay, Patricia García, Pascale Allotey, Robin Gorna , et al. · 2018

Each year, 200 million women have an unmet need for modern contraception, more than 45 million women receive inadequate or no antenatal care, 1 million women and girls acquire HIV, and 25 million abortions are unsafe.1Every Woman Every Chi…

PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells Open

Magesh Muthu, Anders Nordström · 2018

Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in …

Swedish development assistance for health: critical questions to ask going forward Open

Jesper Sundewall, Pia Engstrand, Anders Nordström · 2018

Han som fick världen att lyssna Open

Anders Nordström · 2018

Hans Rosling fick oss alla att lyssna. Han utmanade oss i våra kunskapsluckor och han fick världens ledare att intressera sig för siffror och utvecklingen i världen. Han var en mästare i kommunikation och en folkbildare i världsklass. Häls…

TALKING THE TALK EQUALS WALKING THE WALK? : A Quantitative Study of the Attitude-Action Gap in the Sharing Economy Open

Anders Nordström, Rebecka Esseen · 2018

Customer behavior has always been of interest for business researchers. However, it is just in recent years that there has been an increasing interest in the phenomenon of the sharing economy. It has been suggested that there is an ongoing…

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