Anders Omsland
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View article: Ectopic overexpression and CRISPRi-based knockdown of <i>Chlamydia trachomatis</i> ObgE inhibits RB replication and EB reformation
Ectopic overexpression and CRISPRi-based knockdown of <i>Chlamydia trachomatis</i> ObgE inhibits RB replication and EB reformation Open
Chlamydia trachomatis is an obligate intracellular bacterium of major clinical significance. While untreated sexually transmitted infections can result in pelvic inflammatory disease and infertility, ocular infections can cause the blindin…
View article: The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms
The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms Open
Bacteria in the Chlamydiales order are obligate intracellular parasites of eukaryotic cells. Within this order, the genus Chlamydia contains the causative agents of a number of clinically important infections in humans. Biovars of Chlamydi…
View article: The chlamydial transcriptional regulator Euo is a key switch in cell form developmental progression but is not involved in the committed step to the formation of the infectious form
The chlamydial transcriptional regulator Euo is a key switch in cell form developmental progression but is not involved in the committed step to the formation of the infectious form Open
Bacteria in the genus Chlamydia are a significant health burden worldwide. They infect a wide range of vertebrate animals, including humans and domesticated animals. In humans, C. psittaci can cause zoonotic pneumonia, while C. pneumoniae …
View article: <i>Coxiella burnetii</i> inhibits nuclear translocation of TFEB, the master transcription factor for lysosomal biogenesis
<i>Coxiella burnetii</i> inhibits nuclear translocation of TFEB, the master transcription factor for lysosomal biogenesis Open
Coxiella burnetii is a highly infectious, Gram-negative, obligate intracellular bacterium and the causative agent of human Q fever. The Coxiella Containing Vacuole (CCV) is a modified phagolysosome that forms through fusion with host endos…
View article: The chlamydial transcriptional regulator Euo is a key switch in cell form developmental progression but is not involved in the committed step to the formation of the infectious form
The chlamydial transcriptional regulator Euo is a key switch in cell form developmental progression but is not involved in the committed step to the formation of the infectious form Open
Bacteria in the genus Chlamydia are a significant health burden world wide. They infect a wide range of vertebrate animals including humans and domesticated animals. In humans, C. psittaci can cause zoonotic pneumonia while C. pneumoniae c…
View article: The T3SS structural and effector genes of <i>Chlamydia trachomatis</i> are expressed in distinct phenotypic cell forms
The T3SS structural and effector genes of <i>Chlamydia trachomatis</i> are expressed in distinct phenotypic cell forms Open
Bacteria in the chlamydiales order are obligate intracellular parasites of eukaryotic cells. Within this order, the genus Chlamydia contains the causative agents of a number of clinically important infections of humans. Biovars of C. trach…
View article: Metabolism and physiology of pathogenic bacterial obligate intracellular parasites
Metabolism and physiology of pathogenic bacterial obligate intracellular parasites Open
Bacterial obligate intracellular parasites (BOIPs) represent an exclusive group of bacterial pathogens that all depend on invasion of a eukaryotic host cell to reproduce. BOIPs are characterized by extensive adaptation to their respective …
View article: <i>Drosophila melanogaster</i> Sting mediates <i>Coxiella burnetii</i> infection by reducing accumulation of reactive oxygen species
<i>Drosophila melanogaster</i> Sting mediates <i>Coxiella burnetii</i> infection by reducing accumulation of reactive oxygen species Open
The Gram-negative bacterium Coxiella burnetii is the causative agent of query fever in humans and coxiellosis in livestock. C. burnetii infects a variety of cell types, tissues, and animal species including mammals and arthropods, but ther…
View article: Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain
Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain Open
Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii , the biothreat pathogen that causes Q fever, as in vitro propagation of this or…
View article: Evaluating the UV-C sensitivity of Coxiella burnetii in skim milk using a bench-scale collimated beam system and comparative thermal sensitivity study by high-temperature short-time pasteurization
Evaluating the UV-C sensitivity of Coxiella burnetii in skim milk using a bench-scale collimated beam system and comparative thermal sensitivity study by high-temperature short-time pasteurization Open
Introduction: Coxiella burnetii is a zoonotic Gram-negative obligate intracellular bacterial pathogen and the causative agent of query (Q) fever in humans. Contamination of milk by C. burnetii , as a consequence of livestock infection, is …
View article: Evaluating UV-C sensitivity of<i>Coxiella burnetii</i>in Skim Milk using a Bench-Scale Collimated Beam System and Comparative Study with High-Temperature Short-Time Pasteurization
Evaluating UV-C sensitivity of<i>Coxiella burnetii</i>in Skim Milk using a Bench-Scale Collimated Beam System and Comparative Study with High-Temperature Short-Time Pasteurization Open
Coxiella burnetii is a zoonotic Gram-negative obligate intracellular bacterial pathogen and the causative agent of Query (Q) fever in humans. Contamination of milk by C. burnetii as a consequence of livestock infection is a significant pub…
View article: Expression and structure of the <i>Chlamydia trachomatis</i> DksA ortholog
Expression and structure of the <i>Chlamydia trachomatis</i> DksA ortholog Open
Chlamydia trachomatis is a bacterial obligate intracellular parasite and a significant cause of human disease, including sexually transmitted infections and trachoma. The bacterial RNA polymerase-binding protein DksA is a transcription fac…
View article: The sRNA Regulated Protein DdbA Is Involved in Development and Maintenance of the Chlamydia trachomatis EB Cell Form
The sRNA Regulated Protein DdbA Is Involved in Development and Maintenance of the Chlamydia trachomatis EB Cell Form Open
The chlamydial small non coding RNA, IhtA, regulates the expression of both HctA and DdbA, the uncharacterized product of the C. trachomatis L2 CTL0322 gene. HctA is a small, highly basic, DNA binding protein that is expressed late in deve…
View article: Conditional impairment of <i>Coxiella burnetii</i> by glucose-6P dehydrogenase activity
Conditional impairment of <i>Coxiella burnetii</i> by glucose-6P dehydrogenase activity Open
Coxiella burnetii is a bacterial obligate intracellular parasite and the etiological agent of query (Q) fever. While the C. burnetii genome has been reduced to ∼2 Mb as a likely consequence of genome streamlining in response to parasitism,…
View article: Natural genetic variation in <i>Drosophila melanogaster</i> reveals genes associated with <i>Coxiella burnetii</i> infection
Natural genetic variation in <i>Drosophila melanogaster</i> reveals genes associated with <i>Coxiella burnetii</i> infection Open
The gram-negative bacterium Coxiella burnetii is the causative agent of Query (Q) fever in humans and coxiellosis in livestock. Host genetics are associated with C. burnetii pathogenesis both in humans and animals; however, it remains unkn…
View article: Single-Inclusion Kinetics of <i>Chlamydia trachomatis</i> Development
Single-Inclusion Kinetics of <i>Chlamydia trachomatis</i> Development Open
Chlamydia trachomatis is an obligate intracellular bacterium that can cause trachoma, cervicitis, urethritis, salpingitis, and pelvic inflammatory disease. To establish infection in host cells, Chlamydia must complete a multiple-cell-type …
View article: Predicted iron metabolism genes in hard ticks and their response to iron reduction in Dermacentor andersoni cells
Predicted iron metabolism genes in hard ticks and their response to iron reduction in Dermacentor andersoni cells Open
For most organisms, iron is an essential nutrient due to its role in fundamental cellular processes. Insufficient iron causes sub-optimal metabolism with potential effects on viability, while high levels of iron are toxic due to the format…
View article: Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone
Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone Open
Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (Q) fever. During natural infection of female animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, a…
View article: Critical Role for Molecular Iron in Coxiella burnetii Replication and Viability
Critical Role for Molecular Iron in Coxiella burnetii Replication and Viability Open
Host organisms restrict the availability of iron to invading pathogens in order to reduce pathogen replication. To counteract the host’s response to infection, bacteria can rely on redundant mechanisms to obtain biologically diverse forms …
View article: Natural Genetic Variation in<i>Drosophila melanogaster</i>Reveals Genes Associated with<i>Coxiella burnetii</i>Infection
Natural Genetic Variation in<i>Drosophila melanogaster</i>Reveals Genes Associated with<i>Coxiella burnetii</i>Infection Open
The gram-negative bacterium Coxiella burnetii is the causative agent of Query (Q) fever in humans and coxiellosis in livestock. Association between host genetic background and Coxiella burnetii pathogenesis has been demonstrated both in hu…
View article: Cell Type Development in<i>Chlamydia trachomatis</i>Follows a Program Intrinsic to the Reticulate Body
Cell Type Development in<i>Chlamydia trachomatis</i>Follows a Program Intrinsic to the Reticulate Body Open
The obligate intracellular bacterial pathogen Chlamydia trachomatis ( Ctr ) is reliant on an unusual developmental cycle consisting of two cell forms termed the elementary body (EB) and the reticulate body (RB). The EB is infectious and ut…
View article: Controlled replication of ‘ <i>Candidatus Liberibacter asiaticus</i> ‘ DNA in citrus leaf discs
Controlled replication of ‘ <i>Candidatus Liberibacter asiaticus</i> ‘ DNA in citrus leaf discs Open
Summary ‘ Candidatus Liberibacter asiaticus ’ is a fastidious bacterium and a putative agent of citrus greening disease (a.k.a., huanglongbing, HLB), a significant agricultural disease that affects citrus fruit quality and tree health. In …
View article: Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells
Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells Open
Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a conserved enzyme in lipid A biosynthesis, are antibiotic candidates against Gram-negative pathogens. Here we report …
View article: Impact of Active Metabolism on Chlamydia trachomatis Elementary Body Transcript Profile and Infectivity
Impact of Active Metabolism on Chlamydia trachomatis Elementary Body Transcript Profile and Infectivity Open
Bacteria of the genus Chlamydia include the significant human pathogens Chlamydia trachomatis and C. pneumoniae . All chlamydiae are obligate intracellular parasites that depend on infection of a host cell and transition through a biphasic…
View article: Osmotic Compounds Enhance Antibiotic Efficacy against Acinetobacter baumannii Biofilm Communities
Osmotic Compounds Enhance Antibiotic Efficacy against Acinetobacter baumannii Biofilm Communities Open
Biofilm-associated infections are a clinical challenge, in part because a hydrated matrix protects the bacterial community from antibiotics. Herein, we evaluated how different osmotic compounds (maltodextrin, sucrose, and polyethylene glyc…
View article: Physicochemical and Nutritional Requirements for Axenic Replication Suggest Physiological Basis for Coxiella burnetii Niche Restriction
Physicochemical and Nutritional Requirements for Axenic Replication Suggest Physiological Basis for Coxiella burnetii Niche Restriction Open
Bacterial obligate intracellular parasites are clinically significant animal and human pathogens. Central to the biology of these organisms is their level of adaptation to intracellular replication niches associated with physicochemical an…