Anders Östlund
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View article: Role of MNX1-mediated Histone Modifications and PBX Gene Family in MNX1-induced Leukemogenesis
Role of MNX1-mediated Histone Modifications and PBX Gene Family in MNX1-induced Leukemogenesis Open
The t(7;12)(q36;p13) AML subtype in pediatric patients is associated with the upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their rela…
View article: Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13) Open
Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is a recurrent translocation in AML in infants or very young children and was recently included in the World Health Organization (WHO) Classification of Hematolymphoid Tumors. AML with t(7…
View article: Altered enhancer-promoter interaction leads to <i>MNX1</i> expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
Altered enhancer-promoter interaction leads to <i>MNX1</i> expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13) Open
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and pancreas homeobox 1 [MNX1] and …
View article: Altered enhancer-promoter interaction leads to<i>MNX1</i>expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
Altered enhancer-promoter interaction leads to<i>MNX1</i>expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13) Open
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between breakpoint partners ( MNX1 and ETV6 ) has only been reported in a subs…
View article: Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation
Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation Open
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such as AML with translocation t(7;12)(q36;p13) leading to an MNX1::ETV6 fusion along with high expression of MNX1. We have identified the transforming eve…
View article: Mnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric Acute Myeloid Leukemia with t(7;12)(q36;p13)
Mnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric Acute Myeloid Leukemia with t(7;12)(q36;p13) Open
Certain subtypes of acute myeloid leukemia (AML) in children have still inferior outcome. One of these AML subtypes has a translocation t(7;12)(q36;p13), always leading to high expression of MNX1 and often to MNX1::ETV6 fusion expression. …
View article: Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid Leukemia Induces the Disease Through Altering Histone Methylation
Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid Leukemia Induces the Disease Through Altering Histone Methylation Open
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome. One of these has a translocation t(7;12)(q36;p13) leading to a MNX1 :: ETV6 fusion along with high expression of MNX1. Here we identified the transforming …
View article: An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of <scp>MNX1</scp> and a block in differentiation of the erythroid and megakaryocytic lineages
An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of <span>MNX1</span> and a block in differentiation of the erythroid and megakaryocytic lineages Open
Acute myeloid leukemia (AML) results from aberrant hematopoietic processes and these changes are frequently initiated by chromosomal translocations. One particular subtype, AML with translocation t(7;12)(q36;p13), is found in children diag…
View article: Pandemic Restrictions and Spatiotemporal Crime Patterns in New York, São Paulo, and Stockholm
Pandemic Restrictions and Spatiotemporal Crime Patterns in New York, São Paulo, and Stockholm Open
Studies are showing evidence of the effect of changes in routine activities due to the 2020 COVID-19 pandemic on crime levels in many cities worldwide. This study evaluates the potential impact of the COVID-19 pandemic on temporal and spat…
View article: Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting
Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting Open
Purpose Trauma is a leading cause of mortality, with major bleeding and trauma-induced coagulopathy (TIC) contributing to negative patient outcomes. Treatments for TIC include tranexamic acid (TXA), fresh frozen plasma (FFP), and coagulati…
View article: A retrospective register study comparing fibrinogen treated trauma patients with an injury severity score matched control group
A retrospective register study comparing fibrinogen treated trauma patients with an injury severity score matched control group Open
Background Fibrinogen concentrate (FC) is frequently used to treat bleeding trauma patients, although the clinical effects are not well known. In this study we describe demographic and clinical outcome data in a cohort of trauma patients r…
View article: A criteria-directed protocol for in-hospital triage of trauma patients
A criteria-directed protocol for in-hospital triage of trauma patients Open
Objective To better match hospital resources to patients’ needs of trauma care, a protocol for facilitating in-hospital triage decisions was implemented at a Swedish level I trauma centre. In the protocol, physiological parameters, anatomi…