Anders Palmquist
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View article: Mind the gap: Standardising preclinical testing of bone-repair biomaterials
Mind the gap: Standardising preclinical testing of bone-repair biomaterials Open
View article: Osseointegration of Nitrogen‐Containing Bisphosphonate Coatings on Dental Implants: An Experimental Pilot Study
Osseointegration of Nitrogen‐Containing Bisphosphonate Coatings on Dental Implants: An Experimental Pilot Study Open
To compare the osseointegration properties of two different types of nitrogen‐containing bisphosphonate (N‐BP)‐coated dental implants in an experimental in vivo sheep model. In total, eight sheep were divided into two groups receiving impl…
View article: Mechanical and thermal efficiency of a single drill system for bone-anchored hearing implants
Mechanical and thermal efficiency of a single drill system for bone-anchored hearing implants Open
Purpose This study aimed to evaluate the mechanical performance, heat generation, bone distortion, and characteristics of bone chips generated during drilling using a novel one-step guided drill system (MONO) for installing the bone-anchor…
View article: Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality Open
In bone, critical size defects pose substantial challenge in maxillofacial and orthopedic reconstructions as they are incapable of spontaneous regeneration. In such cases, autografts, allografts, and bone graft substitutes are used. Calciu…
View article: Effect of aging treatments on mechanical, chemical, and antibacterial properties of a β-type Ti–Nb–Cu alloy for implant applications
Effect of aging treatments on mechanical, chemical, and antibacterial properties of a β-type Ti–Nb–Cu alloy for implant applications Open
View article: Anodized Ti6Al4V-ELI, electroplated with copper is bactericidal against Staphylococcus aureus and enhances macrophage phagocytosis
Anodized Ti6Al4V-ELI, electroplated with copper is bactericidal against Staphylococcus aureus and enhances macrophage phagocytosis Open
Implants aim to restore skeletal dysfunction associated with ageing and trauma, yet infection and ineffective immune responses can lead to failure. This project characterized the microbiological and host cell responses to titanium alloy wi…
View article: Re-osseointegration of titanium after experimental implant loosening
Re-osseointegration of titanium after experimental implant loosening Open
A novel rat model demonstrates that osseointegrated titanium implants subjected to a single traumatic overload can fully re-osseointegrate under healthy conditions, restoring biomechanical stability without lasting effects on peri-implant …
View article: Race for the surface between THP-1 macrophages and Staphylococcus aureus on various titanium implants with well-defined topography and wettability
Race for the surface between THP-1 macrophages and Staphylococcus aureus on various titanium implants with well-defined topography and wettability Open
Gristina et al. (1987) suggested that the fate of a biomaterial is decided in a "race for the surface" between pathogens and the host. To gain deeper insight into the mechanisms behind this concept, we investigated the "race for the surfac…
View article: The Effect of Powder Reuse on Electron Beam Melting for Biomedical Implants
The Effect of Powder Reuse on Electron Beam Melting for Biomedical Implants Open
The ability of additive manufacturing to generate intricate structures has led to its popularity and widespread use in a variety of applications, ranging from the production of biomedical implants to aircraft components. Additive manufactu…
View article: Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow
Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow Open
Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclasti…
View article: Macrophage-to-osteocyte communication: Impact in a 3D in vitro implant-associated infection model
Macrophage-to-osteocyte communication: Impact in a 3D in vitro implant-associated infection model Open
Macrophages and osteocytes are important regulators of inflammation, osteogenesis and osteoclastogenesis. However, their interactions under adverse conditions, such as biomaterial-associated infection (BAI) are not fully understood. We aim…
View article: Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice
Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice Open
Tartrate-resistant acid phosphatase (TRAP) serum levels reflect osteoclast number, bone remodeling activity, and fracture risk. Deletion or loss of function of TRAP results in short stature in mice and man. Yet, the impact and mechanisms o…
View article: Mesoscale characterization of osseointegration around an additively manufactured genistein-coated implant
Mesoscale characterization of osseointegration around an additively manufactured genistein-coated implant Open
Given the hierarchical nature of bone and bone interfaces, osseointegration, namely the formation of a direct bone-implant contact, is best evaluated using a multiscale approach. However, a trade-off exists between field of view and spatia…
View article: Toward a disruptive, minimally invasive small finger joint implant concept: Cellular and molecular interactions with materials in vivo
Toward a disruptive, minimally invasive small finger joint implant concept: Cellular and molecular interactions with materials in vivo Open
View article: Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout Open
Juvenile rainbow trout exhibit a remarkable capacity to recover from cardiac injury caused by myocardial ischemia. Recovery from cardiac damage occurs through adaptive ventricular remodeling, coupled with a rapid cardiac revascularization …
View article: Ultrastructure and Nanoporosity of Human Bone Shown with Correlative On-Axis Electron and Spectroscopic Tomographies
Ultrastructure and Nanoporosity of Human Bone Shown with Correlative On-Axis Electron and Spectroscopic Tomographies Open
Mineralized collagen fibrils are the building block units of bone at the nanoscale. While it is known that collagen fibrils are mineralized both inside their gap zones (intra-fibrillar mineralization) and on their outer surfaces (extra-fib…
View article: Leptin receptor gene deficiency minimally affects osseointegration in rats
Leptin receptor gene deficiency minimally affects osseointegration in rats Open
Metabolic syndrome represents a cluster of conditions such as obesity, hyperglycaemia, dyslipidaemia, and hypertension that can lead to type 2 diabetes mellitus and/or cardiovascular disease. Here, we investigated the influence of obesity …
View article: Targeting Pseudomonas aeruginosa quorum sensing with sodium salicylate modulates immune responses in vitro and in vivo
Targeting Pseudomonas aeruginosa quorum sensing with sodium salicylate modulates immune responses in vitro and in vivo Open
Introduction Chronic infections are a major clinical challenge in hard-to-heal wounds and implanted devices. Pseudomonas aeruginosa is a common causative pathogen that produces numerous virulence factors. Due to the increasing problem of a…
View article: Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys
Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys Open
Metastable Ti–Nb alloys are promising bone-implant materials due to improved mechanical biofunctionality and biocompatibility. To overcome increasing bacterial infection risk, alloying with antibacterial elements is a promising strategy. T…
View article: Shedding light (… electrons) on human bone ultrastructure with correlative on-axis electron tomography and energy dispersive X-ray spectroscopy tomography
Shedding light (… electrons) on human bone ultrastructure with correlative on-axis electron tomography and energy dispersive X-ray spectroscopy tomography Open
Mineralized collagen fibrils are the building block units of bone at the nanoscale. While it is known that collagen fibrils are mineralized both inside their gap zones (intra-fibrillar mineralization) and on their outer surfaces (extra-fib…
View article: Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: Microscale characterization of femur and calvarium
Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: Microscale characterization of femur and calvarium Open
Metabolic abnormalities, such as diabetes mellitus and obesity, can impact bone quantity and/or bone quality. In this work, we characterize bone material properties, in terms of structure and composition, in a novel rat model with congenic…
View article: Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues
Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues Open
View article: Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels Open
The possibility of decreasing the dissolution rate of SiN coatings using Fe and C is promising and the released ions were demonstrated to be compatible with microglia viability, in both 2D cultures and 3D collagen hydrogels.
View article: Effect of Minor Gallium Addition on Corrosion, Passivity, and Antibacterial Behaviour of Novel Β-Type Ti-Nb Alloys
Effect of Minor Gallium Addition on Corrosion, Passivity, and Antibacterial Behaviour of Novel Β-Type Ti-Nb Alloys Open
View article: Multimodal and Multiscale Characterization of the <scp>Bone‐Bacteria</scp> Interface in a Case of <scp>Medication‐Related</scp> Osteonecrosis of the Jaw
Multimodal and Multiscale Characterization of the <span>Bone‐Bacteria</span> Interface in a Case of <span>Medication‐Related</span> Osteonecrosis of the Jaw Open
Medication‐related osteonecrosis of the jaw (MRONJ) is a known side effect of bisphosphonates (BPs). Although bacterial infection is usually present, the etiology of MRONJ remains unknown. Here we apply a multimodal and multiscale (micro‐t…
View article: The impact of medication on osseointegration and implant anchorage in bone determined using removal torque—A review
The impact of medication on osseointegration and implant anchorage in bone determined using removal torque—A review Open
View article: Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone
Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone Open
Osseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthope…
View article: Complex geometry and integrated macro-porosity: Clinical applications of electron beam melting to fabricate bespoke bone-anchored implants
Complex geometry and integrated macro-porosity: Clinical applications of electron beam melting to fabricate bespoke bone-anchored implants Open
The last decade has witnessed rapid advancements in manufacturing technologies for biomedical implants. Additive manufacturing (or 3D printing) has broken down major barriers in the way of producing complex 3D geometries. Electron beam mel…
View article: Impact of Leptin Receptor (LepR) Gene Deficiency and Type 2 Diabetes Mellitus on Endochondral and Intramembranous Ossification in a Rat Model
Impact of Leptin Receptor (LepR) Gene Deficiency and Type 2 Diabetes Mellitus on Endochondral and Intramembranous Ossification in a Rat Model Open
View article: Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope
Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope Open