Anders Wall
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View article: [ <sup>18</sup> F]RO948 Tau PET Imaging in Early and Late‐Onset Alzheimer's Disease: Regional Evolution and Correlations with Plasma Biomarkers
[ <sup>18</sup> F]RO948 Tau PET Imaging in Early and Late‐Onset Alzheimer's Disease: Regional Evolution and Correlations with Plasma Biomarkers Open
Background Using [18F]RO948 as a tau PET ligand, we assessed tau deposition in a cohort of memory clinic patients and cognitively unimpaired controls. Regional tau binding was then compared to levels of plasma p ‐Tau217, p ‐Tau181, p ‐Tau2…
View article: Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human Open
Rationale Monoamine triple reuptake inhibitors (TRIs) inhibit central dopamine, norepinephrine, and serotonin transporters, restoring functional monoamine neurotransmission. Objectives This clinical trial evaluated the safety, tolerability…
View article: Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes
Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes Open
Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles in depressiv…
View article: Longitudinal cognitive trajectories in ADAD: The relationship with glucose metabolism [<sup>18</sup>F]FDG PET
Longitudinal cognitive trajectories in ADAD: The relationship with glucose metabolism [<sup>18</sup>F]FDG PET Open
Background [ 18 F]FDG PET is essential since it allows us to differentiate between different dementia disorders/types, revealing distinct neurodegenerative patterns in those predisposed to the condition. Individuals with Autosomal Dominant…
View article: GABA<sub>A</sub> Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study
GABA<sub>A</sub> Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study Open
Introduction: Gamma-aminobutyric acid (GABA) deficiency is suggested in depressive disorders, along with alterations in cortical excitability. However, whether these excitability changes are related to GABAA receptor availability is largel…
View article: Reactive astrocytes as imaged with 11C‐DED in patients with different dementia disorders
Reactive astrocytes as imaged with 11C‐DED in patients with different dementia disorders Open
Background Neuroinflammation, which receives ever increasing interest in neurodegenerative diseases, comprises a heterogeneous cascade of events that are thought to be related to the downstream neurodegeneration. The aim of this study was …
View article: Chronic cerebral blood flow alterations in traumatic brain injury and sports-related concussions
Chronic cerebral blood flow alterations in traumatic brain injury and sports-related concussions Open
Injury severity correlated with CBF, cognitive function, and cortical thickness. CBF also correlated with sex and was reduced in female, not male, athletes. Chronic CBF changes may contribute to the persistent injury mechanisms in TBI and …
View article: E-Cigarette Aerosol Deposition and Disposition of [11C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
E-Cigarette Aerosol Deposition and Disposition of [11C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations Open
Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the …
View article: Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?
Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches? Open
Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We…
View article: [18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer’s disease
[18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer’s disease Open
Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimer’s disease (AD); however, its prognostic utility remains unproven. In a longitudinal, multi-modal, prognostic stud…
View article: Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease
Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease Open
Our proof-of-concept study is the first to show that microstructural and macrostructural changes can reflect underlying neuroinflammatory mechanisms in early stages of Alzheimer disease (AD). The findings support a role for neuroinflammati…
View article: Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET
Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET Open
[18F]THK5317 is a PET tracer for in-vivo imaging of tau associated with Alzheimer's disease (AD). This work aimed to evaluate optimal timing for standardized uptake value ratio (SUVR) measures with [18F]THK5317 and automated generation of …
View article: Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study
Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study Open
The average (SD) age of symptom onset for PSEN1 H163Y is 51 ± 7 years according to previous studies. However, we present a case of a biomarker-verified reduction in penetrance in a mutation carrier who was still symptom-free at the age of …
View article: Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease Open
Introduction Cross‐sectional findings using the tau tracer [ 18 F]THK5317 (THK5317) have shown that [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardi…
View article: A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer’s Disease in a Clinical Setting
A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer’s Disease in a Clinical Setting Open
Assessments of brain glucose metabolism (18F-FDG-PET) and cerebral amyloid burden (11C-PiB-PET) in mild cognitive impairment (MCI) have shown highly variable performances when adopted to predict progression to dementia due to Alzheimer's d…
View article: Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms
Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms Open
Absence of increased premenstrual right-sided relative 5-HTP-derived activity of the dorsolateral prefrontal cortices was found to strongly correlate to premenstrual irritability. A causal relationship here seems plausible, and the finding…
View article: Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device
Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device Open
Background Targeted delivery of nerve growth factor (NGF) has emerged as a potential therapy for Alzheimer’s disease (AD) due to its regenerative effects on basal forebrain cholinergic neurons. This hypothesis has been tested in patients w…
View article: Comparability of [<sup>18</sup>F]THK5317 and [<sup>11</sup>C]PIB blood flow proxy images with [<sup>18</sup>F]FDG positron emission tomography in Alzheimer’s disease
Comparability of [<sup>18</sup>F]THK5317 and [<sup>11</sup>C]PIB blood flow proxy images with [<sup>18</sup>F]FDG positron emission tomography in Alzheimer’s disease Open
For amyloid positron emission tomography tracers, the simplified reference tissue model derived ratio of influx rate in target relative to reference region (R 1 ) has been shown to serve as a marker of brain perfusion, and, due to the stro…
View article: Comparison of Early-Phase <sup>11</sup>C-Deuterium-l-Deprenyl and <sup>11</sup>C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease
Comparison of Early-Phase <sup>11</sup>C-Deuterium-l-Deprenyl and <sup>11</sup>C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease Open
The 1- to 4-min early-frame intervals of (11)C-DED or (11)C-PiB are suitable surrogate measures for brain perfusion. (11)C-DED binding is independent of brain perfusion, and thus (11)C-DED PET can provide information on both functional (br…
View article: Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease
Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease Open
Alzheimer's disease is a multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation and neurodegeneration, where the interrelationships between the different pathophysiological events are not yet we…