Anders Wallin
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View article: The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts
The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts Open
INTRODUCTION It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer's disease (AD) pathology and associated vascular burden. METHODS We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia…
View article: Coordinated international comparisons between optical clocks connected via fiber and satellite links
Coordinated international comparisons between optical clocks connected via fiber and satellite links Open
Optical clocks provide ultraprecise frequency references that are vital for international metrology as well as for tests of fundamental physics. To investigate the level of agreement between different clocks, we simultaneously measured the…
View article: Editorial. CCCB: The journal at age 5
Editorial. CCCB: The journal at age 5 Open
The journal Cerebral Circulation, Cognition & Behavior (CCCB) was conceived to serve at the border zone between the fields of cognition, brain vascular function, cerebrovascular disease and neurodegeneration. An umbrella term often used fo…
View article: The Associations Between Serum Insulin-like Growth Factor-I, Brain White Matter Volumes, and Cognition in Mild Cognitive Impairment and Alzheimer’s Disease
The Associations Between Serum Insulin-like Growth Factor-I, Brain White Matter Volumes, and Cognition in Mild Cognitive Impairment and Alzheimer’s Disease Open
Background: Insulin-like growth factor-I (IGF-I) regulates myelin, but little is known whether IGF-I associates with white matter functions in subjective and objective mild cognitive impairment (SCI/MCI) or Alzheimer’s disease (AD). Object…
View article: Baseline levels of soluble amyloid precursor proteins predict conversion to subcortical small-vessel disease
Baseline levels of soluble amyloid precursor proteins predict conversion to subcortical small-vessel disease Open
Introduction: The Gothenburg Mild Cognitive Impairment (MCI) study is a longitudinal mono-center study of patients seeking help for cognitive complaints at the memory clinic in Gothenburg, Sweden. The study includes both pre-clinical diagn…
View article: Low serum HDL-cholesterol is associated with the risk of subcortical small vessel type of dementia
Low serum HDL-cholesterol is associated with the risk of subcortical small vessel type of dementia Open
Introduction: There are conflicting results whether serum lipid pattern is related to the amount of white matter hyperintensities (WMHs) on magnetic resonance imaging. Little is known of the associations between serum lipid pattern and the…
View article: Effects of demographic and lifestyle factors on cognitive speed, attention and executive function measured by the Trail Making Tests A and B in healthy adults
Effects of demographic and lifestyle factors on cognitive speed, attention and executive function measured by the Trail Making Tests A and B in healthy adults Open
Introduction: The Swedish CArdioPulmonarybioImage Study (SCAPIS) implements the use of new imaging technologies, advances in large-scale ‘omics’ and epidemiological analyses to widely characterize a cohort of 30 000 healthy women and men. …
View article: Entropy-based explanations of serial position and learning effects in ordinal responses to word list tests
Entropy-based explanations of serial position and learning effects in ordinal responses to word list tests Open
Measuring a person’s cognitive abilities, such as memory and learning, is central in many medical conditions to reliably diagnose, treat and monitor disease progression. Common tests typically include tasks of recalling sequences of blocks…
View article: Improving validity of the trail making test with alphabet support
Improving validity of the trail making test with alphabet support Open
Objective The Trail Making Test (TMT) is commonly used worldwide to evaluate cognitive decline and car driving ability. However, it has received critique for its dependence on the Latin alphabet and thus, the risk of misclassifying some pa…
View article: Multiomics machine learning identifies inflammation molecular pathways in prodromal Alzheimer’s Disease
Multiomics machine learning identifies inflammation molecular pathways in prodromal Alzheimer’s Disease Open
Mild Cognitive Impairment (MCI) is a phase that can precede Alzheimer’s Disease (AD). To better understand the molecular mechanisms underlying conversion from MCI to AD, we applied a battery of machine learning algorithms on 800 samples fr…
View article: Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease
Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease Open
Introduction This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzhe…
View article: Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks
Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks Open
Background and objective Blood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for pot…
View article: Multiomics profiling of human plasma and CSF reveals ATN derived networks and highlights causal links in Alzheimer’s disease
Multiomics profiling of human plasma and CSF reveals ATN derived networks and highlights causal links in Alzheimer’s disease Open
INTRODUCTION This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the Amyloid/Tau/Neurodegeneration [AT(N)] framework, MCI conversion to AD, and genetic risk for AD. METH…
View article: Testosterone associates differently with body mass index and age in serum and cerebrospinal fluid in men
Testosterone associates differently with body mass index and age in serum and cerebrospinal fluid in men Open
Dear Editor, Testosterone treatment of hypogonadal men has increased substantially during the last 20 years. Although the indications for treatment of hypogonadism differ between countries, both specific symptoms and serum testosterone bel…
View article: Shared CSF Biomarker Profile in Idiopathic Normal Pressure Hydrocephalus and Subcortical Small Vessel Disease
Shared CSF Biomarker Profile in Idiopathic Normal Pressure Hydrocephalus and Subcortical Small Vessel Disease Open
Introduction In this study, we examine similarities and differences between 52 patients with idiopathic normal pressure hydrocephalus (iNPH) and 17 patients with subcortical small vessel disease (SSVD), in comparison to 28 healthy controls…
View article: Blood‐brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein‐β in patients with subcortical small‐vessel disease
Blood‐brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein‐β in patients with subcortical small‐vessel disease Open
Introduction Subcortical small‐vessel disease (SSVD) is the most common vascular cognitive disorder. However, because no disease‐specific cerebrospinal fluid (CSF) biomarkers are available for SSVD, our aim was to identify such markers. Me…
View article: What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders?
What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders? Open
•Controversial registration of aducanumab for Alzheimer's Disease•Aducanumab is the subject of post-licensing observational studies aiming to follow the effects of the drug•Given the high prevalence of cerebrovascular pathology it is impor…
View article: Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort
Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort Open
Background: physiological differences between males and females could contribute to the development of Alzheimer’s Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. Methods: We explored whe…
View article: Plasma Proteomic Biomarkers Relating to Alzheimer’s Disease: A Meta-Analysis Based on Our Own Studies
Plasma Proteomic Biomarkers Relating to Alzheimer’s Disease: A Meta-Analysis Based on Our Own Studies Open
Background and Objective : Plasma biomarkers for the diagnosis and stratification of Alzheimer’s disease (AD) are intensively sought. However, no plasma markers are well established so far for AD diagnosis. Our group has identified and val…
View article: Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort
Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort Open
BACKGROUND Physiological differences between males and females could contribute to the development of AD. Here, we examined metabolic pathways that may lead to precision medicine initiatives. METHODS We explored whether sex modifies the as…
View article: Dickkopf-1 Overexpression <i>in vitro</i> Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology
Dickkopf-1 Overexpression <i>in vitro</i> Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology Open
Background: Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer’s disease (AD). However, the effect of DKK1 expression on protein expression, and whet…
View article: Altered thyroid hormone profile in patients with Alzheimer’s disease
Altered thyroid hormone profile in patients with Alzheimer’s disease Open
Thyroid hormones were moderately altered in mild AD dementia with increased serum FT4, and in addition, the reduced T3/T4 ratios may suggest decreased peripheral conversion of T4 to T3. Furthermore, serum T3 levels were related to brain st…