András Iring
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View article: A smartphone based AI model to detect left ventricular systolic dysfunction on 12-lead ECG
A smartphone based AI model to detect left ventricular systolic dysfunction on 12-lead ECG Open
Background Despite echocardiography being essential for cardiac assessment, a point-of-care tool for rapid left ventricular ejection fraction (LVEF) evaluation is lacking in current clinical practice, highlighting the need for a widescale,…
View article: Blood oxygen regulation via P2Y12R expressed in the carotid body
Blood oxygen regulation via P2Y12R expressed in the carotid body Open
Background Peripheral blood oxygen monitoring via chemoreceptors in the carotid body (CB) is an integral function of the autonomic cardiorespiratory regulation. The presence of the purinergic P2Y12 receptor (P2Y12R) has been implicated in …
View article: Validation of an artificial intelligence model for 12-lead ECG interpretation
Validation of an artificial intelligence model for 12-lead ECG interpretation Open
Background The electrocardiogram (ECG) is one of the most accessible and comprehensive diagnostic tools to assess cardiac abnormalities. However, automated ECG interpretation remains inferior to physician interpretation in terms of accurac…
View article: Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development
Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development Open
At high levels, extracellular ATP operates as a “danger” molecule under pathologic conditions through purinergic receptors, including the ionotropic P2X7 receptor (P2X7R). Its endogenous activation is associated with neurodevelopmental dis…
View article: Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth
Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth Open
Within the tumor microenvironment, tumor cells and endothelial cells regulate each other. While tumor cells induce angiogenic responses in endothelial cells, endothelial cells release angiocrine factors, which act on tumor cells and other …
View article: Involvement of P2Y<sub>12</sub> receptors in a nitroglycerin‐induced model of migraine in male mice
Involvement of P2Y<sub>12</sub> receptors in a nitroglycerin‐induced model of migraine in male mice Open
Background and Purpose P2Y 12 receptors regulate different forms of pain and inflammation. In this study, we investigated the participation of P2Y 12 receptors in an animal model of migraine. Experimental Approach We tested the effect of t…
View article: Central inhibition of P2Y<sub>12</sub>R differentially regulates survival and neuronal loss in MPTP-induced Parkinsonism in mice
Central inhibition of P2Y<sub>12</sub>R differentially regulates survival and neuronal loss in MPTP-induced Parkinsonism in mice Open
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. During PD progression, microglia, the resident immune cell…
View article: Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis
Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis Open
Atherosclerosis develops preferentially in areas of the arterial system, in which blood flow is disturbed. Exposure of endothelial cells to disturbed flow has been shown to induce inflammatory signaling, including NF-κB activation, which l…
View article: P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia
P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia Open
Background: It has been consistently reported that the deficiency of the adenosine triphosphate (ATP) sensitive purinergic receptor P2X7 (P2X7R) ameliorates symptoms in animal models of brain diseases. Objective: This study aimed to invest…
View article: Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure Open
Hypertension is a primary risk factor for cardiovascular diseases including myocardial infarction and stroke. Major determinants of blood pressure are vasodilatory factors such as nitric oxide (NO) released from the endothelium under the i…
View article: Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation
Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation Open
The vascular endothelium is constantly exposed to mechanical forces, including fluid shear stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and convert the mechanical signal of laminar flow into athe…
View article: Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release Open
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are released from the endothelium under the influence of fluid shear stress exerted by flowing blood. Flow-induced endothelial release of ATP and …
View article: Adaptation of the cerebrocortical circulation to carotid artery occlusion involves blood flow redistribution between cortical regions and is independent of eNOS
Adaptation of the cerebrocortical circulation to carotid artery occlusion involves blood flow redistribution between cortical regions and is independent of eNOS Open
Cerebral circulation is secured by feed-forward and feed-back control pathways to maintain and eventually reestablish the optimal oxygen and nutrient supply of neurons in case of disturbances of the cardiovascular system. Using the high te…
View article: The effects of CB1-receptor blockade on mean arterial pressure (A) and cerebrocortical blood flow (B).
The effects of CB1-receptor blockade on mean arterial pressure (A) and cerebrocortical blood flow (B). Open
Mean arterial pressure (MAP, n = 10) and cerebrocortical blood flow (CoBF, n = 20) are shown before (0 min) as well as 1, 2, 4, 8, 16 and 32 minutes after intravenous administration of 10 mg kg−1 AM-251 (•) or its vehicle (○) in urethane-a…
View article: P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction Open
Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are released from the endothelium in response to fluid she…