András Kapùs
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View article: MRCKα/CDC42BPA Is a Suppressor of Gef-H1/RhoA/MRTF Signaling in Tubular Cells
MRCKα/CDC42BPA Is a Suppressor of Gef-H1/RhoA/MRTF Signaling in Tubular Cells Open
Pro-fibrotic mediators derived from tubular cells have a central role in he development of kidney fibrosis. Our previous studies revealed that GEF-H1 (ARHGEF2)/RhoA signalling is a crucial regulator of tubular mediator release. Fibrotic st…
View article: Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling
Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling Open
Right ventricular (RV) function under pressure overload (PO) is critical in congenital heart disease outcomes. While moderate left ventricular (LV) pressure‐loading has been shown to benefit RV function, the mechanisms and optimal degree o…
View article: M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import
M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import Open
Multiple mechanisms were proposed to mediate the nuclear import of TAZ/YAP, transcriptional co-activators regulating organ growth and regeneration. Our earlier observations showed that TAZ/YAP harbor a C-terminal, unconventional nuclear lo…
View article: Myocardin-Related Transcription Factor Mediates Epithelial Fibrogenesis in Polycystic Kidney Disease
Myocardin-Related Transcription Factor Mediates Epithelial Fibrogenesis in Polycystic Kidney Disease Open
Polycystic kidney disease (PKD) is characterized by extensive cyst formation and progressive fibrosis. However, the molecular mechanisms whereby the loss/loss-of-function of Polycystin 1 or 2 (PC1/2) provokes fibrosis are largely unknown. …
View article: Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease
Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease Open
Polycystic kidney disease (PKD) is characterized by extensive cyst formation and progressive fibrosis. However, the molecular mechanisms whereby the loss/loss-of-function of Polycystin 1 or 2 (PC1/2) provokes fibrosis are largely unknown. …
View article: Concurrent left ventricular pressure-loading improves right ventricular function, remodeling, and molecular signaling in response to pulmonary artery banding
Concurrent left ventricular pressure-loading improves right ventricular function, remodeling, and molecular signaling in response to pulmonary artery banding Open
Background Studies have established the significance of right ventricle (RV) function in individuals with many congenital heart diseases, however the impact of pressure overload (PO) on the RV, concomitant with changes in LV pressure, has …
View article: Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control
Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control Open
Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus of intense preclinical research and clinical implementation for decades. MSCs have multilineage differentiation capacity, support…
View article: The cellular mechanisms of kidney fibrosis: A hitherto understudies aspect of polycystic kidney disease
The cellular mechanisms of kidney fibrosis: A hitherto understudies aspect of polycystic kidney disease Open
The cellular mechanisms of kidney fibrosis: A hitherto understudies aspect of polycystic kidney disease In this exclusive Q&A session with Dr. Andras Kapus, we unravel the complexities of chronic kidney disease in general and Polycystic Ki…
View article: Nuclear Import and Export of YAP and TAZ
Nuclear Import and Export of YAP and TAZ Open
Yes-associated Protein (YAP) and its paralog Transcriptional Coactivator with PDZ-binding Motif (TAZ) are major regulators of gene transcription/expression, primarily controlled by the Hippo pathway and the cytoskeleton. Integrating an arr…
View article: Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles
Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles Open
Atypical chemokine receptor-1 (ACKR1), previously known as the Duffy antigen receptor for chemokines, is a widely conserved cell surface protein that is expressed on erythrocytes and the endothelium of post-capillary venules. In addition t…
View article: Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock
Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock Open
RIPC was hepatoprotective in WT mice following HSR but not in parkin-/- mice. Loss of protection in parkin-/- mice corresponded with the failure of RIPC plus HSR to upregulate the mitophagic process. Improving mitocho…
View article: ACTIVATION OF THE MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN (MAVS) FOLLOWING LIVER ISCHEMIA/REPERFUSION AND ITS EFFECT ON INFLAMMATION AND INJURY
ACTIVATION OF THE MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN (MAVS) FOLLOWING LIVER ISCHEMIA/REPERFUSION AND ITS EFFECT ON INFLAMMATION AND INJURY Open
Resuscitation of trauma patients after hemorrhagic shock causes global I/R, which may contribute to organ dysfunction. Oxidative stress resulting from I/R is known to induce signaling pathways leading to the production of inflammatory mole…
View article: Advancing Discovery Research in Nephrology in Canada: A Conference Report From the 2021 Molecules and Mechanisms Mediating Kidney Health and Disease (M3K) Scientific Meeting and Investigator Summit
Advancing Discovery Research in Nephrology in Canada: A Conference Report From the 2021 Molecules and Mechanisms Mediating Kidney Health and Disease (M3K) Scientific Meeting and Investigator Summit Open
Purpose of conference: New discoveries arising from investigations into fundamental aspects of kidney development and function in health and disease are critical to advancing kidney care. Scientific meetings focused specifically on fundame…
View article: Improved SARS-CoV-2 PCR Detection and Genotyping with Double-Bubble Primers
Improved SARS-CoV-2 PCR Detection and Genotyping with Double-Bubble Primers Open
A new approach for improved RT-PCR is described. It is based on primers designed to form controlled stem-loop and homodimer configurations, hence the name 'double-bubble' primers. The primers contain three main regions for efficient RT-PCR…
View article: Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms Open
Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the tra…
View article: MRTF: Basic Biology and Role in Kidney Disease
MRTF: Basic Biology and Role in Kidney Disease Open
A lesser known but crucially important downstream effect of Rho family GTPases is the regulation of gene expression. This major role is mediated via the cytoskeleton, the organization of which dictates the nucleocytoplasmic shuttling of a …
View article: Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts
Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts Open
We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myofibroblast activation. Kindlin-2 is co-upregulated with the myofibroblast marker α-smooth …
View article: Myocardin-Related Transcription Factor and Serum Response Factor Regulate Cilium Resorption and Ciliogenesis by Both Transcriptional and Local Mechanisms
Myocardin-Related Transcription Factor and Serum Response Factor Regulate Cilium Resorption and Ciliogenesis by Both Transcriptional and Local Mechanisms Open
View article: Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models
Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Open
The alkylating agent platinum is first-line chemotherapy treatment for high-grade serous carcinomas (HGSC) of tubal-ovarian origin. Platinum compounds cause DNA damage and induce apoptotic cell death in the bulk tumor population. However, …
View article: Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells
Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells Open
View article: The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1
The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1 Open
mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we show that the Na+/K+/2Cl- co…
View article: Profibrotic epithelial phenotype: a central role for MRTF and TAZ
Profibrotic epithelial phenotype: a central role for MRTF and TAZ Open
View article: Mediated nuclear import and export of TAZ and the underlying molecular requirements
Mediated nuclear import and export of TAZ and the underlying molecular requirements Open
Nucleocytoplasmic distribution of Yap/TAZ is regulated by the Hippo pathway and the cytoskeleton. While interactions with cytosolic and nuclear “retention factors” (14–3–3 and TEAD) are known to control their localization, fundamental aspe…
View article: Investigation Of Epithelial-To-Mesenchymal Transition Through Microcontact Printing
Investigation Of Epithelial-To-Mesenchymal Transition Through Microcontact Printing Open
We have used microcontact printing as a means of simulating injury or wounds in a healthy monolayer of LLC PK1 cells to study the expression of Epithelial-to-Mesenchymal Transition (EMT) signature proteins. Cells were patterned on PDMS sub…
View article: Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac
Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac Open
Claudin-2 (Cldn-2) is a channel-forming tight junction (TJ) protein in the proximal tubules that mediates paracellular Na + transport and has also emerged as a regulator of proliferation and migration. Expression of Cldn-2 is altered by nu…
View article: Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition
Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition Open
RATIONALE: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone morphogenetic protein receptor 2) signaling and increased signal…
View article: TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism
TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism Open
Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-talk regulating cell fate-determining and fibrogenic pathways…
View article: Table of Contents
Table of Contents Open
View article: Sirtuin 1 Activation Reduces Transforming Growth Factor-β1–Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease
Sirtuin 1 Activation Reduces Transforming Growth Factor-β1–Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease Open
View article: Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration
Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration Open
Repair of airway epithelium after injury requires migration of neighboring epithelial cells to injured areas. However, the molecular mechanisms regulating airway epithelial cell migration is not well defined. We have previously shown that …