András Varró
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View article: A Comparative Study of the Rapid (IKr) and Slow (IKs) Delayed Rectifier Potassium Currents in Undiseased Human, Dog, Rabbit, and Guinea Pig Cardiac Ventricular Preparations
A Comparative Study of the Rapid (IKr) and Slow (IKs) Delayed Rectifier Potassium Currents in Undiseased Human, Dog, Rabbit, and Guinea Pig Cardiac Ventricular Preparations Open
To understand the large inter-species variations in drug effects on repolarization, the properties of the rapid (IKr) and the slow (IKs) components of the delayed rectifier potassium currents were compared in myocytes isolated from undisea…
View article: Author response: Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Author response: Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Materials and methods Results Discussion Appendix 1 Appendix 2 Appendix 3 Data availability References Article and author information Metrics Abstra…
View article: Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations
Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations Open
Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QT c interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane …
View article: Reviewer #1 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Reviewer #1 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Author Response: Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Author Response: Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Reviewer #3 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Reviewer #3 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Reviewer #3 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Reviewer #3 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Reviewer #1 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Reviewer #1 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Reviewer #2 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Reviewer #2 (Public Review): Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Selective Inhibition of Cardiac Late Na+ Current Is Based on Fast Offset Kinetics of the Inhibitor
Selective Inhibition of Cardiac Late Na+ Current Is Based on Fast Offset Kinetics of the Inhibitor Open
The present study was designed to test the hypothesis that the selectivity of blocking the late Na+ current (INaL) over the peak Na+ current (INaP) is related to the fast offset kinetics of the Na+ channel inhibitor. Therefore, the effects…
View article: Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies Open
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models wit…
View article: Altered cardiac repolarization associated with cellular electrophysiological remodeling following chronic testosterone undecanoate administration in a canine model
Altered cardiac repolarization associated with cellular electrophysiological remodeling following chronic testosterone undecanoate administration in a canine model Open
Funding Acknowledgements Type of funding sources: None. Background The influence of testosterone on ventricular ion channels is widely investigated. Despite the legally stipulated availability of different androgen anabolic steroids (AAS),…
View article: Conductance Changes of Na+ Channels during the Late Na+ Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes
Conductance Changes of Na+ Channels during the Late Na+ Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes Open
Late sodium current (INa,late) is an important inward current contributing to the plateau phase of the action potential (AP) in the mammalian heart. Although INa,late is considered as a possible target for antiarrhythmic agents, several as…
View article: Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise
Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise Open
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac dea…
View article: Author response: Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise
Author response: Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The hea…
View article: The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells
The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells Open
Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-channels and intracellular Ca 2+ -handling. The fundamental role of the inward Na + /Ca 2+ exchanger (NCX) is firmly established. However, little is known about…
View article: A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5
A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5 Open
Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit of the vol…
View article: Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibilty in a canine model of elite exercise
Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibilty in a canine model of elite exercise Open
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac dea…
View article: The hidden cardiotoxic effect of rofecoxib on rabbit ventricular preparations
The hidden cardiotoxic effect of rofecoxib on rabbit ventricular preparations Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Research, Development and Innovation Office Hungary Introduction Unexpected ischaemia-induced cardiac adverse events…
View article: Cardiac remodeling accompanied by increased arrhythmia susceptibility in a dog model of chronic high-intensity endurance training
Cardiac remodeling accompanied by increased arrhythmia susceptibility in a dog model of chronic high-intensity endurance training Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This work was supported by NKFIH grants (K-19992, K-135464) and GINOP-2.3.2-15-2016-00047. Background Despite the cardiovascu…
View article: The Inhibition of the Small-Conductance Ca2+-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation
The Inhibition of the Small-Conductance Ca2+-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation Open
Sinus pacemaking is based on tight cooperation of intracellular Ca2+ handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca2+-activated K+-channel (ISK) that could co…
View article: Long-Term Endurance Exercise Training Alters Repolarization in a New Rabbit Athlete’s Heart Model
Long-Term Endurance Exercise Training Alters Repolarization in a New Rabbit Athlete’s Heart Model Open
In the present study, the effect of long-term exercise training was investigated on myocardial morphological and functional remodeling and on proarrhythmic sensitivity in a rabbit athlete’s heart model. New-Zealand white rabbits were train…