André EX Brown
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View article: High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations
High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations Open
View article: The <i>C. elegans</i> gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance
The <i>C. elegans</i> gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance Open
The nematode C. elegans does not have eyes but can respond to aversive UV and blue light stimulation and even distinguish colours. The gustatory receptor homolog LITE-1 was identified in forward genetic screens for worms that failed to res…
View article: Screening conditions and constructs for attempted genetic transformation of <i>C. elegans</i> by <i>Agrobacterium</i>
Screening conditions and constructs for attempted genetic transformation of <i>C. elegans</i> by <i>Agrobacterium</i> Open
Manipulating gene expression within a model organism is important for reverse genetic experimentation, and while techniques to generate transgenic C. elegans are available, they are optimised for creating individual lines. The ability to c…
View article: High-throughput behavioural phenotyping of 25<i>C. elegans</i>disease models including patient-specific mutations
High-throughput behavioural phenotyping of 25<i>C. elegans</i>disease models including patient-specific mutations Open
Genetic diagnosis is fast and cheap, challenging our capacity to evaluate the functional impact of novel disease-causing variants or identify potential therapeutics. Model organisms including C. elegans present the possibility of systemati…
View article: Author response: High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models
Author response: High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models Open
View article: An improved neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens
An improved neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens Open
High-resolution posture tracking of C. elegans has applications in genetics, neuroscience, and drug screening. While classic methods can reliably track isolated worms on uniform backgrounds, they fail when worms overlap, coil, or move in c…
View article: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Author response: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Author response: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
View article: Redox-Responsive Polymeric Nanogels as Efficient mRNA Delivery Vehicles in Caenorhabditis elegans
Redox-Responsive Polymeric Nanogels as Efficient mRNA Delivery Vehicles in Caenorhabditis elegans Open
Efficient delivery of sensitive nucleic acid payloads, including mRNA, in Caenorhabditis elegans remains challenging, especially with traditional, labor-intensive transgenesis methods. We addressed these challenges using polymeric n…
View article: Author response: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Author response: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
View article: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity
Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity Open
Amyotrophic lateral sclerosis can be caused by abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. Here, we use a C. elegans model for TDP-43-induced toxicity to identify the biological mechanisms that…
View article: Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans Open
View article: Reviewer #3 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Reviewer #3 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Reviewer #2 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Reviewer #2 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Reviewer #1 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Reviewer #1 (Public Review): Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: A new <i>Caenorhabditis elegans</i> model to study copper toxicity in Wilson disease
A new <i>Caenorhabditis elegans</i> model to study copper toxicity in Wilson disease Open
Wilson disease (WD) is caused by mutations in the ATP7B gene that encodes a copper (Cu) transporting ATPase whose trafficking from the Golgi to endo‐lysosomal compartments drives sequestration of excess Cu and its further excretion from he…
View article: Rebalancing the motor circuit restores movement in a<i>Caenorhabditis elegans</i>model for TDP-43-toxicity
Rebalancing the motor circuit restores movement in a<i>Caenorhabditis elegans</i>model for TDP-43-toxicity Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia are caused by the abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. How TDP-43 accumulation leads to disease symptoms is not well-chara…
View article: Only Spot a Few Blacks the Higher I Go: Occupational Segregation and the COVID-19 Pandemic
Only Spot a Few Blacks the Higher I Go: Occupational Segregation and the COVID-19 Pandemic Open
This project examines whether there exists a link between occupational segregation by race and labor market outcomes during the COVID-19 pandemic. We estimate the extent to which workers employed in occupations with higher concentrations o…
View article: Systematic creation and phenotyping of Mendelian disease models in <i>C. elegans</i> : towards large-scale drug repurposing
Systematic creation and phenotyping of Mendelian disease models in <i>C. elegans</i> : towards large-scale drug repurposing Open
There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug dev…
View article: Rebalancing the Motor Circuit Restores Movement in a Caenorhabditis elegans Model for TDP-43 Toxicity
Rebalancing the Motor Circuit Restores Movement in a Caenorhabditis elegans Model for TDP-43 Toxicity Open
View article: Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications
Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications Open
View article: Bi-allelic loss-of-function variants in <i>PPFIBP1</i> cause a neurodevelopmental disorder with microcephaly, epilepsy and periventricular calcifications
Bi-allelic loss-of-function variants in <i>PPFIBP1</i> cause a neurodevelopmental disorder with microcephaly, epilepsy and periventricular calcifications Open
PPFIBP1 encodes for the liprin-β1 protein which has been shown to play a role in neuronal outgrowth and synapse formation in Drosophila melanogaster . By exome sequencing, we detected nine ultra-rare homozygous loss-of-function variants in…
View article: Megapixel camera arrays enable high-resolution animal tracking in multiwell plates
Megapixel camera arrays enable high-resolution animal tracking in multiwell plates Open
Tracking small laboratory animals such as flies, fish, and worms is used for phenotyping in neuroscience, genetics, disease modelling, and drug discovery. An imaging system with sufficient throughput and spatiotemporal resolution would be …
View article: A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Open
A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs) are synthesized from G…
View article: Increased fidelity of protein synthesis extends lifespan
Increased fidelity of protein synthesis extends lifespan Open
View article: Dataset supporting the article "Megapixel camera arrays for high-resolution animal tracking in multiwell plates"
Dataset supporting the article "Megapixel camera arrays for high-resolution animal tracking in multiwell plates" Open
IB and LF contributed equally. This deposition contains the supporting dataset for the article: Megapixel camera arrays for high-resolution animal tracking in multiwell plates Ida Barlow, Luigi Feriani, Eleni Minga, Adam…
View article: Dataset supporting the article "Megapixel camera arrays for high-resolution animal tracking in multiwell plates"
Dataset supporting the article "Megapixel camera arrays for high-resolution animal tracking in multiwell plates" Open
IB and LF contributed equally. This deposition contains the supporting dataset for the article: Megapixel camera arrays for high-resolution animal tracking in multiwell plates Ida Barlow, Luigi Feriani, Eleni Minga, Adam M…
View article: Facilitating community gardening and urban agriculture.
Facilitating community gardening and urban agriculture. Open
A systematic review of master planning strategies that bring about positive outcomes for the communal space.