Catarina Brito
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View article: 3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV Open
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure. Liver …
View article: Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development
Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development Open
Microglia are critical regulators of brain homeostasis and immune responses in the central nervous system (CNS). However, existing human‐based models fail to reproduce the early and complex microglia‐neural cell interactions. The different…
View article: Supplementary Figure 4 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 4 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 4
View article: Supplementary Figure 1 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 1 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 1
View article: Supplementary Figure 6 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 6 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 6
View article: Data from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Data from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Tumor-associated macrophages (TAM) exhibit a dual role in tumor progression and antitumor immunity. However, understanding the functional states and molecular mechanisms of antitumor TAMs remains a challenge. Herein, we show that intratumo…
View article: Supplementary Figure 2 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 2 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 2
View article: Supplementary Figure 7 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 7 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 7
View article: Supplementary Figure 5 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 5 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 5
View article: Supplementary Figure 8 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 8 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 8
View article: Supplementary Figure 9 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 9 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 9
View article: Supplementary Figure 3 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication
Supplementary Figure 3 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication Open
Supplementary Figure 3
View article: Engineering a perfusion bioreactor system for hiPSC-derived progenitor co-culture capturing microglial features in CNS development
Engineering a perfusion bioreactor system for hiPSC-derived progenitor co-culture capturing microglial features in CNS development Open
Microglia are critical regulators of brain homeostasis and immune responses in the central nervous system (CNS). However, existing human-based models fail to reproduce the early and complex microglia-neural cell interactions. The different…
View article: 3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV Open
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the preclinical models, resulting in therapy failure. Liver i…
View article: Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV
Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV Open
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges due to host immune responses not represented in classical preclinical models. Here, we present a human-induced pluripotent stem…
View article: Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication
Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication Open
Tumor-associated macrophages (TAM) exhibit a dual role in tumor progression and antitumor immunity. However, understanding the functional states and molecular mechanisms of antitumor TAMs remains a challenge. Herein, we show that intratumo…
View article: Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems Open
Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. Cryopreserved PHHs …
View article: Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic <i>Plasmodium berghei</i>
Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic <i>Plasmodium berghei</i> Open
New antimalarial combination therapies with novel modes of action are required to counter the emergence and spread of Plasmodium drug resistance against existing therapeutics. Here, we present a study to evaluate the preventive activity of…
View article: Assessing Novel Antibody‐Based Therapies in Reconstructive 3D Cell Models of the Tumor Microenvironment
Assessing Novel Antibody‐Based Therapies in Reconstructive 3D Cell Models of the Tumor Microenvironment Open
Targeted, combinatorial, and immunomodulatory therapies, such as antibody‐drug conjugates (ADCs) and immunomodulatory antibodies (Abs), are powerful weapons against tumor cells and immune cells within the tumor microenvironment (TME). Ther…
View article: Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV
Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV Open
Introduction: Engineered 3D models employing human induced pluripotent stem cell (hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in the human central nervous system (CNS). Therefore, these comp…
View article: Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids
Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids Open
Purpose Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of visual impairment amongst working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional change…
View article: Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade
Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade Open
Introduction The clinical prognosis of the HER2-overexpressing (HER2-OE) subtype of breast cancer (BC) is influenced by the immune infiltrate of the tumor. Specifically, monocytic cells, which are promoters of pro-tumoral immunosuppression…
View article: 3D human retinal organoid model for the study of early diabetic retinopathy
3D human retinal organoid model for the study of early diabetic retinopathy Open
Diabetic retinopathy (DR) is a significant complication of diabetes and a primary cause of visual impairment among working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional chan…
View article: On improving process efficiency and weld quality in ultrasonic welding of misaligned thermoplastic composite adherends
On improving process efficiency and weld quality in ultrasonic welding of misaligned thermoplastic composite adherends Open
This paper evaluates the potential of changing the welding force and the compliance of the energy director (ED) to reduce the effects caused by misaligned adherends, which were: increased through-thickness heating, reduced size of welded a…
View article: Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer
Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer Open
Predicting patient response to treatment and the onset of chemoresistance are still major challenges in oncology. Chemoresistance is deeply influenced by the complex cellular interactions occurring within the tumor microenvironment (TME), …
View article: Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside Open
Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibit…
View article: Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical <i>Plasmodium</i> Infection Models
Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical <i>Plasmodium</i> Infection Models Open
Combination therapies have emerged to mitigate Plasmodium drug resistance, which has hampered the fight against malaria. M5717 is a potent multistage antiplasmodial drug under clinical development, which inhibits parasite protein synthesis…