André Diedrich
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View article: Correlation of physiological stress as measured by heart rate and blood pressure variability and self-reported anxiety
Correlation of physiological stress as measured by heart rate and blood pressure variability and self-reported anxiety Open
Background Despite lack of data, there is an assumption that anxiety symptoms correspond with a physiological stress response with decreased parasympathetic and increased sympathetic nervous system. Objective To examine whether self-report…
View article: Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome
Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome Open
PurposeMuscle sympathetic nerve activity (MSNA) is valuable for POTS management, but microneurography is clinically impractical. We investigated whether the Valsalva phase 2 diastolic blood pressure rise (DBPVM2l_rise) could be …
View article: Blood Pressure and Autonomic Changes From 12-Weeks of Yoga-Based Slow Breathing Exercises
Blood Pressure and Autonomic Changes From 12-Weeks of Yoga-Based Slow Breathing Exercises Open
Background Slow breathing exercises have been shown to reduce blood pressure and sympathetic tone acutely, though long-term effects are not well documented. Objective Assess changes in blood pressure and autonomic measures from before and …
View article: Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy
Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy Open
Introduction Near-infrared spectroscopy is now a popular method in neuromonitoring. Derived parameters like cerebral oxygenation index or Fast Fourier Transform based coherence estimates between blood pressure and cerebral blood flow have …
View article: Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique
Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique Open
Background: Despite the success of transcatheter aortic valve repair (TAVR) over the past years, its impact on global and cerebral hemodynamics remains largely unexplored. Changes in cerebral blood flow may be associated with delirium, whi…
View article: Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure
Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure Open
Purpose Postprandial hypotension (PPH) defined as a decrease in systolic blood pressure of more than 20 mmHg within 2 h post meal is prevalent in patients with autonomic failure and is associated with negative cardiovascular outcomes. Prev…
View article: Blood Volume Deficit in Postural Orthostatic Tachycardia Syndrome Assessed by Semi-Automated Carbon Monoxide Rebreathing
Blood Volume Deficit in Postural Orthostatic Tachycardia Syndrome Assessed by Semi-Automated Carbon Monoxide Rebreathing Open
Purpose: Semi-automated carbon monoxide (CO) rebreathing method has been introduced as a non-invasive and radioactive-free blood volume estimation method. We tested whether the semi-automated CO rebreathing method can detect the blood volu…
View article: Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity
Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity Open
Background Obesity is associated with resistance to the metabolic (glucose uptake) and vascular (nitric‐oxide mediated dilation and microvascular recruitment) actions of insulin. These vascular effects contribute to insulin sensitivity by …
View article: Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease
Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease Open
View article: Direct comparison of the diagnostic performance of growth differentiation factor 8 in pediatric versus adult heart failure
Direct comparison of the diagnostic performance of growth differentiation factor 8 in pediatric versus adult heart failure Open
GDF-8 did not accurately differentiate between HF patients and normal comparators in neither adults nor in children.
View article: 12-weeks of Slow Breathing Exercises Reduces Blood Pressure among Healthy Normotensive Subjects
12-weeks of Slow Breathing Exercises Reduces Blood Pressure among Healthy Normotensive Subjects Open
Slow breathing exercises are a key component to many mind-body practices and have been shown to reduce blood pressure acutely. Long-term effects on blood pressure and autonomic tone are not well documented. We studied 99 healthy participan…
View article: In memoriam: a celebration of the autonomic contributions of David Robertson (1947–2024)
In memoriam: a celebration of the autonomic contributions of David Robertson (1947–2024) Open
View article: Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest
Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest Open
Impaired cardiovascular autonomic control following space flight or immobilization may limit the ability to cope with additional hemodynamic stimuli. Head-down tilt bedrest is an established terrestrial analog for space flight and offers t…
View article: Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes
Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes Open
Increased renal sodium excretion eliciting body weight loss may promote sympathetic activation. However, sympathetic excitation in the face of increased sodium loss may be attenuated by SGLT2 inhibitor-specific actions.
View article: PO-01-168 PREVALENCE OF ATRIAL FIBRILLATION IN PATIENTS WITH PRIMARY AUTONOMIC FAILURE
PO-01-168 PREVALENCE OF ATRIAL FIBRILLATION IN PATIENTS WITH PRIMARY AUTONOMIC FAILURE Open
View article: Post–COVID-19 Afferent Baroreflex Failure
Post–COVID-19 Afferent Baroreflex Failure Open
A 47-year-old male with a history of psoriatic arthritis and type II diabetes contracted COVID-19 in 2020 complicated by pneumonia and acute hypoxic respiratory failure requiring hospitalization.He received supplemental oxygen, convalescen…
View article: Use of Valsalva Maneuver to Detect Late-Onset Delayed Orthostatic Hypotension
Use of Valsalva Maneuver to Detect Late-Onset Delayed Orthostatic Hypotension Open
Background: Standard autonomic testing includes a 10-minute head-up tilt table test to detect orthostatic hypotension. Although this test can detect delayed orthostatic hypotension (dOH) between 3 and 10 minutes of standing, it cannot dete…
View article: Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus
Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus Open
Introduction Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk.…
View article: Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure Open
Background: Supine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous po…
View article: 12-weeks of Slow Breathing Exercises Reduces Blood Pressure among Healthy Normotensive Subjects
12-weeks of Slow Breathing Exercises Reduces Blood Pressure among Healthy Normotensive Subjects Open
Slow breathing exercises are a key component to many mind-body practices used for stress reduction and modulation of autonomic tone, and it has been shown to reduce blood pressure acutely. Long-term effects on blood pressure and autonomic …
View article: Editorial: Methods on the Assessment of Human Baroreflex Function
Editorial: Methods on the Assessment of Human Baroreflex Function Open
EDITORIAL article Front. Neurosci., 28 June 2022Sec. Autonomic Neuroscience https://doi.org/10.3389/fnins.2022.965406
View article: Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion
Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion Open
Background: Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the prec…
View article: Enhanced Parasympathetic Cholinergic Activity Inhibited Lipid-induced Oxidative Stress in Obese African Americans
Enhanced Parasympathetic Cholinergic Activity Inhibited Lipid-induced Oxidative Stress in Obese African Americans Open
Background: African Americans (AAs) are disproportionately affected by cardiovascular disease (CVD), they are 20% more likely to die from CVD than whites, chronic exposure to inflammation and oxidative stress contributes to CVD. In previou…
View article: Endovascular baroreflex amplification and the effect on sympathetic nerve activity in patients with resistant hypertension: A proof-of-principle study
Endovascular baroreflex amplification and the effect on sympathetic nerve activity in patients with resistant hypertension: A proof-of-principle study Open
Background: First in human studies suggest that endovascular baroreflex amplification (EVBA) lowers blood pressure (BP). To explore potential mechanisms for BP reduction, this study examines the effects of EVBA on muscle sympathetic nerve …
View article: Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome
Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome Open
View article: Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation
Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation Open
Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural ac…
View article: Sympathetic vasoconstrictor activity before and after left ventricular assist device implantation in patients with end‐stage heart failure
Sympathetic vasoconstrictor activity before and after left ventricular assist device implantation in patients with end‐stage heart failure Open
Aims Sympathetic overactivity, which predicts poor outcome in patients with heart failure, normalizes following cardiac transplantation. We tested the hypothesis that haemodynamic improvement following left ventricular assist device (LVAD)…
View article: Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level
Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level Open
Background The sympathetic arterial baroreflex is a closed-loop feedback system for stabilizing arterial pressure (AP). Identification of unique functions of the closed system in humans is a challenge. Here we propose an analytic and integ…
View article: Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting – Part 2
Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting – Part 2 Open
The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be…
View article: Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1
Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 Open