André Gie
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View article: 22q11 Deletion Syndrome in young infant presenting with multilevel airway obstruction
22q11 Deletion Syndrome in young infant presenting with multilevel airway obstruction Open
View article: Thoracotomies in Children in Low to Middle Income Countries: The Indications for Surgery
Thoracotomies in Children in Low to Middle Income Countries: The Indications for Surgery Open
Introduction There is a scarcity of data on the utilization of thoracotomy for lung pathology in children in low‐ and middle‐income countries (LMICs). These countries have high burdens of infectious diseases, especially tuberculosis, hydat…
View article: Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections
Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections Open
BACKGROUNDThis longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls.METHODSChildren aged 4–13 years presenting with presumed PTB…
View article: Radial EBUS to Identify Tuberculosis Mediastinal Lymph Nodes for Biopsy in Young Children
Radial EBUS to Identify Tuberculosis Mediastinal Lymph Nodes for Biopsy in Young Children Open
View article: Location-specific pathology analysis of monopodial airways in a rabbit model of bronchopulmonary dysplasia: a proof of principle study
Location-specific pathology analysis of monopodial airways in a rabbit model of bronchopulmonary dysplasia: a proof of principle study Open
Background The airways of the mammalian lung form a tree-like structure, starting from the trachea and branching out to the terminal bronchioles. This tree is composed of heterogeneous sub-structures or compartments, varying in morphologic…
View article: The use of forced oscillation technique in children with restrictive physiology
The use of forced oscillation technique in children with restrictive physiology Open
The forced oscillation technique (FOT) may not identify lung function abnormalities in children with restrictive physiology. FOT findings correlate poorly with spirometry and plethysmography testing in children with diffuse parenchymal …
View article: Is this airway safe?
Is this airway safe? Open
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View article: PTB airway compression complicated by vascular abnormalities and cardiac involvement: A case series demonstrating diagnosis and management
PTB airway compression complicated by vascular abnormalities and cardiac involvement: A case series demonstrating diagnosis and management Open
Introduction Lymphobronchial tuberculosis (LBTB) is a tuberculous lymphadenopathy causing airway compression in young children. While it can occur in older children due to factors such as airway size, wall weakness, and immune reconstituti…
View article: Severe Mycoplasma pneumoniae infection in a young child: An emerging increase in incidence?
Severe Mycoplasma pneumoniae infection in a young child: An emerging increase in incidence? Open
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View article: SARS‐CoV‐2 coinfection in children with severe airway obstruction due to pulmonary tuberculosis
SARS‐CoV‐2 coinfection in children with severe airway obstruction due to pulmonary tuberculosis Open
Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic had a significant impact on tuberculosis (TB) control globally, with the number of new TB diagnoses decreasing. Coinfection with some viruses, especiall…
View article: Letter from South Africa
Letter from South Africa Open
South Africa has many struggles. Respiratory health is one of them. The main challenge faced by South African clinicians and researchers is to address respiratory health in the face of gross inequality (Gini index 0.63). This disparity is …
View article: The challenge of interpreting diminished mid‐expiratory flow in the presence of normal <scp>FEV<sub>1</sub></scp> and <scp>FVC</scp>
The challenge of interpreting diminished mid‐expiratory flow in the presence of normal <span>FEV<sub>1</sub></span> and <span>FVC</span> Open
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View article: Is this airway safe?
Is this airway safe? Open
View article: A case of empyema necessitans in a paediatric patient with Mycobacterium tuberculosis
A case of empyema necessitans in a paediatric patient with Mycobacterium tuberculosis Open
Empyema necessitans is a rare complication of pneumonia in which pus formed in the pleural cavity extends into the surrounding tissue. In children it is mostly caused by Mycobacterium tuberculosis, but other bacterial organisms are implica…
View article: Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model
Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model Open
Fetal growth restriction (FGR) remains one of the main obstetrical problems worldwide, with consequences beyond perinatal life. Animal models with developmental and structural similarities to the human are essential to understand FGR long-…
View article: Lung function tracking in children with perinatally acquired HIV following early antiretroviral therapy initiation
Lung function tracking in children with perinatally acquired HIV following early antiretroviral therapy initiation Open
Introduction Lung disease remains a frequent complication in children with perinatal HIV infection (CHIV) and exposure without infection (CHEU), resulting in diminished lung function. In CHIV, early antiretroviral therapy (ART) initiation …
View article: Location‐specific pathology analysis of the monopodial pulmonary vasculature in a rabbit model of bronchopulmonary dysplasia—A pilot study
Location‐specific pathology analysis of the monopodial pulmonary vasculature in a rabbit model of bronchopulmonary dysplasia—A pilot study Open
The mammalian pulmonary vasculature consists of functionally and morphologically heterogeneous compartments. When comparing sets of lungs, for example, in disease models or therapeutic interventions, local changes may be masked by the over…
View article: Chronic lung disease in children due to SARS‐CoV‐2 pneumonia: Case series
Chronic lung disease in children due to SARS‐CoV‐2 pneumonia: Case series Open
The reported prevalence of chronic lung disease (CLD) due to coronavirus 2 (severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2)]) pneumonia with the severe acute respiratory syndrome in children is unknown and rarely reported in E…
View article: Prematurity and Hyperoxia Have Different Effects on Alveolar and Microvascular Lung Development in the Rabbit
Prematurity and Hyperoxia Have Different Effects on Alveolar and Microvascular Lung Development in the Rabbit Open
Bronchopulmonary dysplasia (BPD) is a developmental disorder of infants born prematurely, characterized by disrupted alveolarization and microvascular maturation. However, the sequence of alveolar and vascular alterations is currently not …
View article: Fetal Growth Restriction Impairs Lung Function and Neurodevelopment in an Early Preterm Rabbit Model
Fetal Growth Restriction Impairs Lung Function and Neurodevelopment in an Early Preterm Rabbit Model Open
We previously reported the multi-system sequelae of fetal growth restriction, induced by placental underperfusion, in near-term born rabbits, in the immediate neonatal period and up to pre-adolescence. Herein, we describe the pulmonary and…
View article: Placental vascular alterations are associated with early neurodevelopmental and pulmonary impairment in the rabbit fetal growth restriction model
Placental vascular alterations are associated with early neurodevelopmental and pulmonary impairment in the rabbit fetal growth restriction model Open
View article: COVID19‐associated unilateral transient phrenic nerve palsy in a young child with respiratory failure
COVID19‐associated unilateral transient phrenic nerve palsy in a young child with respiratory failure Open
We describe a case of unilateral phrenic nerve palsy due to SARS-COV-2 in a young child, which led to prolonged and complicated ventilation. The child was treated with methylprednisolone and IVIG, which led to a complete recovery of phreni…
View article: ‘Miliary metastasis’ in a child with papillary thyroid cancer
‘Miliary metastasis’ in a child with papillary thyroid cancer Open
Lung disease with diffuse nodules has a broad differential diagnosis. We present a case of childhood papillary thyroid carcinoma with diffuse lung metastases in which the diagnosis was delayed due to fact that the diffuse nodules were cons…
View article: “To the Editor” COVID19-associated unilateral transient phrenic nerve palsy in a young child with respiratory failure
“To the Editor” COVID19-associated unilateral transient phrenic nerve palsy in a young child with respiratory failure Open
We describe a case of unilateral phrenic nerve palsy due to SARS-COV-2 in a young child, which led to prolonged and complicated ventilation. The child was treated with methylprednisolone and IVIG, which led to a complete recovery of phreni…
View article: Foreign body aspiration in two young infants: the devil in the carpet…
Foreign body aspiration in two young infants: the devil in the carpet… Open
Foreign body aspiration is rare in children below 6 months of age. Very young children presenting with stridor, atypical croup presentation, and not responding accordingly, subglottic foreign body aspiration should be considered. These may…
View article: Placental vascular alterations lead to early neurodevelopmental and pulmonary impairment in the rabbit fetal growth restriction model
Placental vascular alterations lead to early neurodevelopmental and pulmonary impairment in the rabbit fetal growth restriction model Open
Fetal growth restriction is one of the leading causes of perinatal mortality and morbidity and has consequences that extend well beyond the neonatal period. Current management relies on timely delivery rather than improving placental funct…
View article: Fatal SARS‐CoV‐2 Omicron variant in a young infant: Autopsy findings
Fatal SARS‐CoV‐2 Omicron variant in a young infant: Autopsy findings Open
SARS-CoV-2 has spread rapidly worldwide since December 2019, but fewer children are diagnosed with SARS-CoV-2 and mortality remains relatively low compared to adults.1 Even fewer neonates and infants are testing SARS-CoV-2 positive and dat…
View article: Childhood lung function following perinatal HIV infection and early antiretroviral therapy initiation: a cross-sectional study
Childhood lung function following perinatal HIV infection and early antiretroviral therapy initiation: a cross-sectional study Open
Despite the introduction of antiretroviral therapy (ART), HIV-associated pulmonary complications remain prevalent in children following perinatal HIV infection. In the post-ART era the incidence of opportunistic infections has decreased; h…
View article: Combination of µCT and light microscopy for generation-specific stereological analysis of pulmonary arterial branches: a proof-of-concept study
Combination of µCT and light microscopy for generation-specific stereological analysis of pulmonary arterial branches: a proof-of-concept study Open
Various lung diseases, including pulmonary hypertension, chronic obstructive pulmonary disease or bronchopulmonary dysplasia, are associated with structural and architectural alterations of the pulmonary vasculature. The light microscopic …
View article: Glomerular developmental delay and proteinuria in the preterm neonatal rabbit
Glomerular developmental delay and proteinuria in the preterm neonatal rabbit Open
Recent advances in neonatal care have improved the survival rate of those born premature. But prenatal conditions, premature birth and clinical interventions can lead to transient and permanent problems in these fragile patients. Premature…