André Gohr
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View article: <i>SF3B1</i>mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
<i>SF3B1</i>mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia Open
Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations in SF3B1 are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are ass…
View article: <i>Insplico</i> : effective computational tool for studying splicing order of adjacent introns genome-wide with short and long RNA-seq reads
<i>Insplico</i> : effective computational tool for studying splicing order of adjacent introns genome-wide with short and long RNA-seq reads Open
Although splicing occurs largely co-transcriptionally, the order by which introns are removed does not necessarily follow the order in which they are transcribed. Whereas several genomic features are known to influence whether or not an in…
View article: IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation Open
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency …
View article: <i>Insplico</i>: Effective computational tool for studying intron splicing order genome-wide with short and long RNA-seq reads
<i>Insplico</i>: Effective computational tool for studying intron splicing order genome-wide with short and long RNA-seq reads Open
Although splicing occurs largely co-transcriptionally, the order by which introns are removed does not necessarily follow the order in which they are transcribed. Whereas several genomic features are known to influence whether or not an in…
View article: The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians Open
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary s…
View article: A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation
A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation Open
Transition from maternal to embryonic transcriptional control is crucial for embryogenesis. However, alternative splicing regulation during this process remains understudied. Using transcriptomic data from human, mouse, and cow preimplanta…
View article: The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians Open
The eutherian placenta is a major site for parental genetic conflict. Here, we identify the X-linked Mbnl3 gene as a novel player in this dispute. Mbnl3 belongs to an RNA binding protein family whose members regulate alternative splicing a…
View article: A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation
A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation Open
The transition from maternal to embryonic transcriptional control is a crucial step in embryogenesis. However, how alternative splicing is regulated during this process and how it contributes to early development is unknown. Using transcri…
View article: Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing
Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing Open
Recursive splicing (RS) starts by defining an "RS-exon," which is then spliced to the preceding exon, thus creating a recursive 5' splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find that the exon junction c…
View article: RES complex is associated with intron definition and required for zebrafish early embryogenesis
RES complex is associated with intron definition and required for zebrafish early embryogenesis Open
Pre-mRNA splicing is a critical step of gene expression in eukaryotes. Transcriptome-wide splicing patterns are complex and primarily regulated by a diverse set of recognition elements and associated RNA-binding proteins. The retention and…
View article: RES complex is associated with intron definition and required for zebrafish early embryogenesis
RES complex is associated with intron definition and required for zebrafish early embryogenesis Open
Pre-mRNA splicing is a critical step of gene expression in eukaryotes. Transcriptome-wide splicing patterns are complex and primarily regulated by a diverse set of recognition elements and associated RNA-binding proteins. The retention and…
View article: An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms
An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms Open
Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in metazoans. However, the functions of most AS events are not known, and programs of regulated splicing remain to be identified. To address these challenge…
View article: PCT and conditional sequence logo at position 19.
PCT and conditional sequence logo at position 19. Open
The structure of this figure is identical to that of Figure 7. Here, we observe more contexts representing a considerable amount of realizations, since only three context (III, VI, VII) represent so few sequences that they can be neglected…
View article: Examples of state-context trees.
Examples of state-context trees. Open
Selected state-context trees of height two representing different sets of disjoint sets of equivalent state-contexts of length two. The fused tree (a)) and the complete tree (c)) define marginal cases of state-context trees underlying a pa…
View article: Divergent Evolution of the Transcriptional Network Controlled by Snf1-Interacting Protein Sip4 in Budding Yeasts
Divergent Evolution of the Transcriptional Network Controlled by Snf1-Interacting Protein Sip4 in Budding Yeasts Open
Cellular responses to starvation are of ancient origin since nutrient limitation has always been a common challenge to the stability of living systems. Hence, signaling molecules involved in sensing or transducing information about limitin…