André Jakob
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View article: Case Report: Successful weaning after 113 days of VV-ECMO in a pediatric patient with severe ARDS following Stevens–Johnson syndrome
Case Report: Successful weaning after 113 days of VV-ECMO in a pediatric patient with severe ARDS following Stevens–Johnson syndrome Open
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an established rescue therapy for severe pediatric acute respiratory distress syndrome (ARDS), but prolonged support is rarely reported. We describe the case of a previously heal…
View article: German pediatric intensive care transport registry: study protocol for a prospective multicenter registry
German pediatric intensive care transport registry: study protocol for a prospective multicenter registry Open
Background In contrast to critical care transport of adults or newborns, transport of pediatric critical care patients in Germany is neither regulated by law nor centrally organized. Due to their different therapeutic needs compared to new…
View article: Mapping Drivers of Coronary Endothelial Activation and Endothelial‐to‐Mesenchymal Transition through Mimicking of Multimediator Inflammation in Kawasaki Disease Context
Mapping Drivers of Coronary Endothelial Activation and Endothelial‐to‐Mesenchymal Transition through Mimicking of Multimediator Inflammation in Kawasaki Disease Context Open
Objective Kawasaki disease (KD) is an acute systemic vasculitis predominantly affecting coronary arteries of infants and children. We recently identified leucin‐rich α‐2‐glycoprotein 1 (LRG‐1) as known transforming growth factor β1 (TGFβ1)…
View article: Diagnosis of Coronary Artery Aneurysm in a Caucasian Population Cohort: Evaluating the Agreement Between Japanese Criteria and Different Z Score Formulas
Diagnosis of Coronary Artery Aneurysm in a Caucasian Population Cohort: Evaluating the Agreement Between Japanese Criteria and Different Z Score Formulas Open
Background/Objectives: Evaluating coronary artery abnormalities (CAAs) in Kawasaki disease (KD) is essential for treatment decisions and long-term management and prognosis. Accurate diagnosis is challenging due to differing criteria across…
View article: Recovery from Pediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2: Follow-Up from a Nationwide German Cohort
Recovery from Pediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2: Follow-Up from a Nationwide German Cohort Open
Our findings confirm the generally favorable intermediate-term outcome in patients with PIMS-TS. However, a subset of patients in our cohort, particularly older children and those requiring intensive care unit care during the acute phase, …
View article: Cardiorespiratory fitness and muscle strength in offspring conceived through assisted reproductive technologies: results from the Munich heARTerY-study
Cardiorespiratory fitness and muscle strength in offspring conceived through assisted reproductive technologies: results from the Munich heARTerY-study Open
View article: The landscape of inter-institutional and multinational collaborations in Kawasaki disease
The landscape of inter-institutional and multinational collaborations in Kawasaki disease Open
Objectives Integrated research potentiates evidence-based knowledge, particularly for uncommon diseases such as Kawasaki disease (KD). The 14th International Kawasaki Disease Symposium focussed on “Fostering global collaborations to solve …
View article: Atrioseptostomía con balón para la transposición de las grandes arterias en Europa: características y resultados actuales
Atrioseptostomía con balón para la transposición de las grandes arterias en Europa: características y resultados actuales Open
View article: Arthroscopic-Assisted vs. Fluoroscopic-Only ORIF of Distal Radius Fractures: Clinical and Economic Perspectives
Arthroscopic-Assisted vs. Fluoroscopic-Only ORIF of Distal Radius Fractures: Clinical and Economic Perspectives Open
Background and Objectives: Distal radius fractures (DRFs) are among the most common fractures globally, with a lifetime incidence of around 9%. They typically present in two age peaks: high-impact trauma in patients under 40 and low-energy…
View article: Twenty-Four Hour Ambulatory Blood Pressure Monitoring in Offspring Conceived Through Assisted Reproductive Technologies
Twenty-Four Hour Ambulatory Blood Pressure Monitoring in Offspring Conceived Through Assisted Reproductive Technologies Open
Background: One in fifty infants is conceived through assisted reproductive technologies (ART). To date, data on the cardiovascular morbidity of ART individuals is ambiguous. This study investigated the vascular function of young ART subje…
View article: Evaluating 3D-printed models for congenital heart disease: impact on parental anxiety and procedural understanding
Evaluating 3D-printed models for congenital heart disease: impact on parental anxiety and procedural understanding Open
Background Evaluation of the impact of 3D-printed models on parental education and anxiety in parents of children with congenital heart disease (CHD) who are undergoing interventions or surgeries. Methods A prospective randomized controlle…
View article: Impact of Acute Energy Drink Consumption on Heart Rate Variability in Children and Adolescents. A Randomized Trial
Impact of Acute Energy Drink Consumption on Heart Rate Variability in Children and Adolescents. A Randomized Trial Open
The EDUCATE study investigated the acute impact of energy drink (ED) consumption on heart rate variability (HRV) in children and adolescents, with a focus on how these stimulant-rich beverages influence cardiac autonomic function. Given th…
View article: Balloon atrioseptostomy for transposition of the great arteries in Europe: characteristics and outcomes
Balloon atrioseptostomy for transposition of the great arteries in Europe: characteristics and outcomes Open
In the current era, BAS can be challenging, and significant complications and complete failures are not uncommon. The use of the umbilical venous route, low-volume BAS catheters, absence of fluoroscopy guidance, and the occurrence of compl…
View article: Evaluation of the cardiorespiratory fitness in Fontan patients by a standardized stair climbing test in comparison to the six minute walking test and cardiopulmonary exercise testing (CPET)
Evaluation of the cardiorespiratory fitness in Fontan patients by a standardized stair climbing test in comparison to the six minute walking test and cardiopulmonary exercise testing (CPET) Open
View article: Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry
Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry Open
BACKGROUND: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual ana…
View article: Severity of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Diminished During Successive Waves of the COVID-19 Pandemic: Data from a Nationwide German Survey
Severity of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Diminished During Successive Waves of the COVID-19 Pandemic: Data from a Nationwide German Survey Open
During the course of COVID-19 pandemic, as each new VOC emerged, PIMS-TS lessened in severity. In parallel, older children came to experience more debilitating disease.
View article: Successful non-invasive imaging of the coronary artery IMT in pediatric patients with Kawasaki disease using high-resolution echocardiography
Successful non-invasive imaging of the coronary artery IMT in pediatric patients with Kawasaki disease using high-resolution echocardiography Open
View article: Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry
Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry Open
Background Patients with Kawasaki disease (KD) with coronary artery involvement require long‐term cardiac care. Although respective evidence‐based recommendations are missing, cardiac catheterization is still considered the gold standard f…
View article: Transcatheter aortic valve implantation and its impact on endothelial function in patients with aortic stenosis
Transcatheter aortic valve implantation and its impact on endothelial function in patients with aortic stenosis Open
Vascular function is impaired in patients with aortic valve stenosis (AS). The impact of transcatheter aortic valve implantation (TAVI) on endothelial function is inconclusive so far. Therefore, we sought to assess the short-term influence…
View article: Acute Cardiovascular Effects of Simultaneous Energy Drink and Alcohol Consumption in Young Adults: A Review of Case Reports
Acute Cardiovascular Effects of Simultaneous Energy Drink and Alcohol Consumption in Young Adults: A Review of Case Reports Open
(1) Background: The aim of this review was to identify and summarize adverse cardiovascular health events associated with the simultaneous consumption of energy drinks (ED) and alcohol. Potential prevention strategies and the implementatio…
View article: Fontan Circulation and Aortic Stiffness: Insights into Vascular Dynamics and Haemodynamic Interplay
Fontan Circulation and Aortic Stiffness: Insights into Vascular Dynamics and Haemodynamic Interplay Open
Increased aortic stiffness predisposes cardiac afterload and influences cardiac function. Congenital heart diseases involving aortic arch malformation and extended cardiovascular surgery, i.e. univentricular heart diseases, can lead to inc…
View article: Influence of donor age and donor-recipient age difference on intimal hyperplasia in pediatric patients with young and adult donors vs. adult patients after heart transplantation
Influence of donor age and donor-recipient age difference on intimal hyperplasia in pediatric patients with young and adult donors vs. adult patients after heart transplantation Open
Aim Optimal selection and allocation of donor hearts is a relevant aspect in transplantation medicine. Donor age and cardiac allograft vasculopathy (CAV) affect post-transplant mortality. To what extent donor age impacts intimal hyperplasi…
View article: Vascular health of fathers with history of intracytoplasmic sperm injection
Vascular health of fathers with history of intracytoplasmic sperm injection Open
The results suggest an unaltered cardiovascular risk profile in fathers with history of ICSI. In the future, prospective multicenter studies are required to validate these preliminary results.
View article: Proteomic mapping identifies serum marker signatures associated with MIS-C specific hyperinflammation and cardiovascular manifestation
Proteomic mapping identifies serum marker signatures associated with MIS-C specific hyperinflammation and cardiovascular manifestation Open
Multisystem inflammatory syndrome in children (MIS-C) shares several clinical and immunological features with Kawasaki Disease (KD) and pediatric hyperinflammation, but the immuno-phenotypic overlap among these clinical mimics is still inc…
View article: Comparison Performance of Spectrogram and Scalogram as Input of Acoustic Recognition Task
Comparison Performance of Spectrogram and Scalogram as Input of Acoustic Recognition Task Open
Acoustic recognition has emerged as a prominent task in deep learning research, frequently utilizing spectral feature extraction techniques such as the spectrogram from the Short-Time Fourier Transform and the scalogram from the Wavelet Tr…
View article: Vascular Health of Females with History of Assisted Reproductive Technology
Vascular Health of Females with History of Assisted Reproductive Technology Open
The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the…
View article: Step by Step: Evaluation of Cardiorespiratory Fitness in Healthy Children, Young Adults, and Patients with Congenital Heart Disease Using a Simple Standardized Stair Climbing Test
Step by Step: Evaluation of Cardiorespiratory Fitness in Healthy Children, Young Adults, and Patients with Congenital Heart Disease Using a Simple Standardized Stair Climbing Test Open
(1) Background: Cardiorespiratory fitness (CRF) is known to be a prognostic factor regarding long-term morbidity and mortality. This study aimed to develop a standardized Stair Climbing Test (SCT) with a reliable correlation to spiroergome…
View article: Familiar Disposition of May–Thurner Syndrome—A Case Series
Familiar Disposition of May–Thurner Syndrome—A Case Series Open
May–Thurner syndrome is a venous compression syndrome of the pelvic vessels that represents a relevant risk factor for thrombus formation. The standard procedure to secure a diagnosis is venography, followed by endovascular therapy as the …
View article: Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children
Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children Open
This case-control study investigates changes in microcirculation and endothelial function in the acute phase of multisystem inflammatory syndrome in children and 3 to 6 months after onset.
View article: Short-Term Changes in Arterial Stiffness Measured by 2D Speckle Tracking in Patients Undergoing Transcatheter Aortic Valve Implantation
Short-Term Changes in Arterial Stiffness Measured by 2D Speckle Tracking in Patients Undergoing Transcatheter Aortic Valve Implantation Open
Arterial stiffness has received increasing interest as a cardiovascular marker in patients with aortic valve stenosis (AS). So far, studies on the impact of aortic valve replacement (AVR) on arterial stiffness have been equivocal. Two-dime…