André L. Simão
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Depression- and exercise-associated stimuli exert contrasting effects on neural stem cell activity and paracrine signaling Open
Adult neurogenesis is dysregulated in neurological disorders, including depression. Adult neural stem cells (NSCs) are close to the vasculature and the cerebrospinal fluid, placing them in an ideal position to receive extrinsic signals and…
E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p Open
Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) affects a heterogeneous group of patients. Among them, those with a cholestatic profile show worse outcomes. Here, we investigated whether E2F2 is involv…
View article: <scp>miR</scp>‐21‐5p promotes <scp>NASH</scp>‐related hepatocarcinogenesis
<span>miR</span>‐21‐5p promotes <span>NASH</span>‐related hepatocarcinogenesis Open
Background and Aims The mechanisms governing the progression of non‐alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain elusive. Here, we evaluated the role of hsa‐miRNA‐21‐5p in N…
Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics Open
Aging involves progressive physiological and metabolic reprogramming to adapt to gradual deterioration of organs and functions. This includes mechanisms of defense against pre-malignant transformations. Thus, certain tumors are more prone …
View article: RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease
RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease Open
Objective Receptor-interacting protein kinase 3 (RIPK3) is a key player in necroptosis execution and an emerging metabolic regulator, whose contribution to non-alcoholic fatty liver disease (NAFLD) is controversial. We aimed to clarify the…
Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning? Open
Hepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide and the third most common cause of cancer-related death. One of the major problems faced by researchers and clinicians in this area is the lack of reliable di…
Activation of necroptosis in human and experimental cholestasis Open
Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate the role of …
Correction: Corrigendum: Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis Open
Scientific Reports 5: Article number: 17528; published online: 01 December 2015; updated: 24 June 2016 The original version of this Article contained an error in the title of the paper, where the word “hepatocellular” was incorrectly given…
Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma Open
Obesity and metabolic syndrome are growing epidemics worldwide and greatly responsible for many liver diseases, including nonalcoholic fatty liver disease (NAFLD). NAFLD often progresses to cirrhosis, end-stage liver failure and hepatocell…