Explanipedia

Fast calcium-dependent reorientation of motile cilia basal bodies in the simple metazoan, Trichoplax Open

Marvin Léria, Magali Requin, Moina-mkou Daroueche, Rachel C. Hill, André Le Bivic , et al. · 2025

SUMMARY Ciliary-based animal locomotion relies on the spatially coordinated beating of motile cilia to displace the body in liquid environments or across solid surfaces. The orientation of ciliary beating largely depends on the rotational …

Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux Open

V Price, Anudi Nanayakkara, Andrea Pasini, Elsa Bazellières, Amélie Vernale , et al. · 2025

Cilia are found on the epithelia of almost all metazoans, so their absence from the epithelia of all but one class of Porifera is puzzling. Homoscleromorph sponges possess ciliated epithelia, but their function and evolutionary history wit…

The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity Open

Thè Nghia Nguyen, Sandy Ribes, Caroline Andrique, M. Requin, Jérôme Bouchet , et al. · 2025

Rare disorders related to tight junction (TJ) proteins have been associated with amelogenesis imperfecta. Pathogenic variants of CLDN10 , encoding claudin-10b, a cation transport pore, cause the autosomal recessive HELIX syndrome (Hypohidr…

La zonula adherens matura, une nouvelle jonction intercellulaire de l’épithélium intestinal Open

Pierre Mangeol, Dominique Massey‐Harroche, Michaël Sebbagh, Fabrice Richard, Pierre-François Lenné , et al. · 2024

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The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology Open

Caroline Rocher, Amélie Vernale, Laura Fierro‐Constaín, Nina Séjourné, Sandrine Chenesseau , et al. · 2024

The comparative study of the four non‐bilaterian phyla (Cnidaria, Placozoa, Ctenophora, and Porifera) provides insights into the origin of bilaterian traits. To complete our knowledge of the cell biology and development of these animals, a…

The placozoan Trichoplax Open

Marvin Léria, Magali Requin, André Le Bivic, Andrea Pasini · 2024

The zonula adherens matura redefines the apical junction of intestinal epithelia Open

Pierre Mangeol, Dominique Massey‐Harroche, Michaël Sebbagh, Fabrice Richard, André Le Bivic , et al. · 2024

Cell–cell apical junctions of epithelia consist of multiprotein complexes that organize as belts regulating cell–cell adhesion, permeability, and mechanical tension: the tight junction ( zonula occludens ), the zonula adherens ( ZA ), and …

Hyper-accumulation of vanadium in animals: Two sponges compete with urochordates Open

Kassandra de Pao Mendonca, Perrine Chaurand, Andréa Campos, Bernard Angeletti, Mauro Rovezzi , et al. · 2023

Crb3 is required to organize the apical domain of multiciliated cells Open

Céline Burcklé, Juliette Raitière, Grégoire Michaux, Laurent Kodjabachian, André Le Bivic · 2023

Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary epidermis of Xenopus laevis embryos, as they mature, dramatically reshape their apical domain to grow cilia, in coord…

L’éponge marine Oscarella lobularis un modèle pour comprendre l’origine et l’évolution des épithéliums Open

Emmanuelle Renard, Quentin Schenkelaars, Caroline Rocher, Amélie Vernale, Kassandra de Pao Mendonca , et al. · 2023

Afin d’émettre des hypothèses sur l’origine et l’évolution des épithéliums, nous développons un modèle d’éponge appartenant à la classe des homoscléromorphes. Les éponges sont l’une des lignées ayant émergé le plus précocement au cours de …

Hyperaccumulation of Vanadium in animals: two sponges compete with urochordates Open

Kassandra de Pao Mendonca, Perrine Chaurand, Andréa Campos, Bernard Angeletti, Mauro Rovezzi , et al. · 2023

Vanadium (V) is the second most abundant transition metal in the oceans. Nevertheless, its concentration in organisms is generally low despite its involvement in various physiological or enzymatic functions. Because exposure to high concen…

CRB3 and ARP2/3 regulate cell biomechanical properties to set epithelial monolayers for collective movement Open

Dominique Massey‐Harroche, Vito Conte, Niels Gouirand, Michaël Sebbagh, André Le Bivic , et al. · 2023

Summary Several cellular processes during morphogenesis, tissue healing or cancer progression involve epithelial to mesenchymal plasticity that leads to collective motion (plasticity?). Even though a rich variety of EMP programs exist, a m…

Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells Open

Céline Burcklé, Juliette Raitière, Laurent Kodjabachian, André Le Bivic · 2023

Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary epidermis of Xenopus laevis embryos, as they mature, dramatically reshape their apical domain to grow cilia, in coord…

Super-resolution imaging uncovers the nanoscopic segregation of polarity proteins in epithelia Open

Pierre Mangeol, Dominique Massey‐Harroche, Fabrice Richard, Jean‐Paul Concordet, Pierre-François Lenné , et al. · 2022

Epithelial tissues acquire their integrity and function through the apico-basal polarization of their constituent cells. Proteins of the PAR and Crumbs complexes are pivotal to epithelial polarization, but the mechanistic understanding of …

Author response: Super-resolution imaging uncovers the nanoscopic segregation of polarity proteins in epithelia Open

Pierre Mangeol, Dominique Massey‐Harroche, Fabrice Richard, Jean‐Paul Concordet, Pierre-François Lenné , et al. · 2022

Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstrac…

Origin and Evolution of Epithelial Cell Types Open

Emmanuelle Renard, André Le Bivic, Carole Borchiellini · 2021

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Mechanoregulation of PDZ Proteins, An Emerging Function Open

Elsa Bazellières, André Le Bivic · 2021

Super-resolution imaging uncovers the nanoscopic segregation of polarity proteins in epithelia Open

Pierre Mangeol, Dominique Massey‐Harroche, Fabrice Richard, Pierre-François Lenné, André Le Bivic · 2020

Epithelial tissues acquire their integrity and function through the apico-basal polarization of their constituent cells. Proteins of the PAR and Crumbs complexes are pivotal to epithelial polarization, but the mechanistic understanding of …

CRB2 controls primary ciliogenesis in association with PAR6α, HOOK2 and RAB8A Open

Magali Barthélémy-Requin, Dominique Massey‐Harroche, Stéphane Audebert, Jean‐Paul Borg, Jan Wijnholds , et al. · 2019

Ciliogenesis is an essential process in animal development and physiology and when affected, the origin of severe pathologies called ciliopathies. CRB2 has been recently implicated when mutated in several pathologies such as retina degener…

Nectins rather than E-cadherin anchor the actin belts at cell-cell junctions of epithelia Open

Pierre Mangeol, Dominique Massey‐Harroche, André Le Bivic, Pierre-François Lenné · 2019

Cell-cell junctions support the mechanical integrity of epithelia by enabling adhesion and tension transmission between neighboring cells. The prevailing mechanistic dogma is that E-cadherin supports and transmits mechanical tension betwee…

A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions Open

Christopher P. Toret, André Le Bivic · 2018

The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP wer…

New genomic data and analyses challenge the traditional vision of animal epithelium evolution Open

Hassiba Belahbib, Emmanuelle Renard, Sébastien Santini, Cyril Jourda, Jean‐Michel Claverie , et al. · 2018

Coupling of Rho family GTPases during mesenchymal-to-epithelial-like transitions Open

Christopher P. Toret, Pruthvi Chavadimane Shivakumar, Pierre-François Lenné, André Le Bivic · 2018

Many metazoan developmental processes require cells to transition between migratory mesenchymal- and adherent epithelial-like states. These transitions require Rho GTPase-mediated actin rearrangements downstream of integrin and cadherin pa…

New genomic data and analyses challenge the traditional vision of animal epithelium evolution Open

Hassiba Belahbib, Emmanuelle Renard, Sébastien Santini, Cyril Jourda, Jean‐Michel Claverie , et al. · 2017

The emergence of epithelia was the foundation of metazoan expansion. To investigate the early evolution of animal epithelia, we sequenced the genome and transcriptomes of two new sponge species to characterize epithelial markers such as th…

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium Open

Pauline Salis, François Payre, Philippe Valenti, Elsa Bazellières, André Le Bivic , et al. · 2017

Animal multicellularity and polarity without Wnt signaling Open

Quentin Schenkelaars, Marine Pratlong, Laurent Kodjabachian, Laura Fierro‐Constaín, Jean Vacelet , et al. · 2017

Acquisition of multicellularity is a central event in the evolution of Eukaryota. Strikingly, animal multicellularity coincides with the emergence of three intercellular communication pathways – Notch, TGF-β and Wnt – all considered as hal…

The PCP pathway regulates Baz planar distribution in epithelial cells Open

Benoît Aigouy, André Le Bivic · 2016

Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration Open

Emilie Pallesi‐Pocachard, Elsa Bazellières, Annelise Viallat-Lieutaud, Marie-Hélène Delgrossi, Magali Barthélémy-Requin , et al. · 2016

The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease Open

Grégoire Michaux, Dominique Massey‐Harroche, Ophélie Nicolle, Marion Rabant, Nicole Brousse , et al. · 2015

Background information Microvillus inclusion disease (MVID) is a genetic disorder affecting intestinal absorption. It is caused by mutations in MYO5B or syntaxin 3 ( STX3 ) affecting apical membrane trafficking. Morphologically, MVID is ch…

Draft Genome Sequence of an Alphaproteobacterium Associated with the Mediterranean Sponge Oscarella lobularis Open

Cyril Jourda, Sébastien Santini, Caroline Rocher, André Le Bivic, Jean‐Michel Claverie · 2015

While sequencing DNA purified from the homoscleromorph sponge Oscarella lobularis , we detected a large number of reads with strong similarity to available alphaproteobacteria gene sequences of family Rhodobacteraceae . Here, we present th…

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